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Q2S8L4

- TRMB_HAHCH

UniProt

Q2S8L4 - TRMB_HAHCH

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, HCH_06365
Organism
Hahella chejuensis (strain KCTC 2396)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei58 – 581S-adenosyl-L-methionine By similarity
Binding sitei83 – 831S-adenosyl-L-methionine By similarity
Binding sitei110 – 1101S-adenosyl-L-methionine By similarity
Active sitei133 – 1331 By similarity
Binding sitei133 – 1331S-adenosyl-L-methionine By similarity
Binding sitei137 – 1371Substrate By similarity
Binding sitei169 – 1691Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHCHE349521:GHAL-6165-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:HCH_06365
OrganismiHahella chejuensis (strain KCTC 2396)
Taxonomic identifieri349521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHahellaceaeHahella
ProteomesiUP000000238: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000288155Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349521.HCH_06365.

Structurei

3D structure databases

ProteinModelPortaliQ2S8L4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1446Interaction with RNA Reviewed prediction
Regioni206 – 2094Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2S8L4-1 [UniParc]FASTAAdd to Basket

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MDNQHLRPIR SFVIRGGRMT ASQQKAFDRL WPEKGLAVEN GLLDLESVFG    50
RRSTVVLEIG FGMGQSLAEM AASEPDADFI GVEVHKPGVG ALLRNMEEQS 100
LENIRIFWDD ANEVIDKCLP DASLDRVQLF FPDPWHKKRH NKRRIVQLEF 150
VQRIRAKLKS GGVFHMATDW EPYAEHMMEI MSEAPGMENI SGAGQFSPRP 200
DTRPVTKFEK RGERLGHGVW DLMFRRVD 228
Length:228
Mass (Da):26,087
Last modified:May 29, 2007 - v2
Checksum:iD1CF33DEC2FC98FD
GO

Sequence cautioni

The sequence ABC33010.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000155 Genomic DNA. Translation: ABC33010.1. Different initiation.
RefSeqiYP_437435.1. NC_007645.1.

Genome annotation databases

EnsemblBacteriaiABC33010; ABC33010; HCH_06365.
GeneIDi3838402.
KEGGihch:HCH_06365.
PATRICi22092928. VBIHahChe29232_5793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000155 Genomic DNA. Translation: ABC33010.1 . Different initiation.
RefSeqi YP_437435.1. NC_007645.1.

3D structure databases

ProteinModelPortali Q2S8L4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349521.HCH_06365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC33010 ; ABC33010 ; HCH_06365 .
GeneIDi 3838402.
KEGGi hch:HCH_06365.
PATRICi 22092928. VBIHahChe29232_5793.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci HCHE349521:GHAL-6165-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KCTC 2396.

Entry informationi

Entry nameiTRMB_HAHCH
AccessioniPrimary (citable) accession number: Q2S8L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: June 11, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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