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Q2S5P8 (UPPP_SALRD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:SRU_0337
OrganismSalinibacter ruber (strain DSM 13855 / M31) [Reference proteome] [HAMAP]
Taxonomic identifier309807 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000250263

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane119 – 13921Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane193 – 21321Helical; Potential
Transmembrane223 – 24321Helical; Potential
Transmembrane250 – 27021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q2S5P8 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 4396DFD7D9688E18

FASTA27028,777
        10         20         30         40         50         60 
MTWWEALLLG LIQGLTEFIP VSSSGHLVLG QYLLGLDKEA ADVTFEVFVH FGTVLSILTV 

        70         80         90        100        110        120 
YWDDVAELVE EAWAGLRAPR AVPTRFAEND TFRLGVFILV TLVPTGVAYV LFREPLEQAF 

       130        140        150        160        170        180 
GSPRFTSAML VGTGVLLLLT RIGPRPDGDL SGVKAFVVGV AQSCALVPGI SRSGATICTA 

       190        200        210        220        230        240 
LYQNVAPERA ANFSFLMLLP VVLGGTVLKG LELMEQGVGA AGLSLGIGTV AAYGSGIGAI 

       250        260        270 
YVVLDVVRRG NLQYFAYYCF LIGGLGLWLL 

« Hide

References

[1]"The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea."
Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H., Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K., Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L., Legault B., Rodriguez-Valera F.
Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13855 / M31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000159 Genomic DNA. Translation: ABC44894.1.
RefSeqYP_444483.1. NC_007677.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309807.SRU_0337.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC44894; ABC44894; SRU_0337.
GeneID3850899.
KEGGsru:SRU_0337.
PATRIC23422997. VBISalRub86502_0350.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMALVGCFQC.
OrthoDBEOG6QP13M.
PhylomeDBQ2S5P8.
ProtClustDBCLSK2774367.

Enzyme and pathway databases

BioCycSRUB309807:GJJD-337-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_SALRD
AccessionPrimary (citable) accession number: Q2S5P8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: January 24, 2006
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families