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Q2S5P8

- UPPP_SALRD

UniProt

Q2S5P8 - UPPP_SALRD

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSRUB309807:GJJD-337-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:SRU_0337
    OrganismiSalinibacter ruber (strain DSM 13855 / M31)
    Taxonomic identifieri309807 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
    ProteomesiUP000008674: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Undecaprenyl-diphosphatasePRO_0000250263Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi309807.SRU_0337.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei92 – 11221HelicalUniRule annotationAdd
    BLAST
    Transmembranei119 – 13921HelicalUniRule annotationAdd
    BLAST
    Transmembranei150 – 17021HelicalUniRule annotationAdd
    BLAST
    Transmembranei193 – 21321HelicalUniRule annotationAdd
    BLAST
    Transmembranei223 – 24321HelicalUniRule annotationAdd
    BLAST
    Transmembranei250 – 27021HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiPIVFDIY.
    OrthoDBiEOG6QP13M.
    PhylomeDBiQ2S5P8.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2S5P8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTWWEALLLG LIQGLTEFIP VSSSGHLVLG QYLLGLDKEA ADVTFEVFVH    50
    FGTVLSILTV YWDDVAELVE EAWAGLRAPR AVPTRFAEND TFRLGVFILV 100
    TLVPTGVAYV LFREPLEQAF GSPRFTSAML VGTGVLLLLT RIGPRPDGDL 150
    SGVKAFVVGV AQSCALVPGI SRSGATICTA LYQNVAPERA ANFSFLMLLP 200
    VVLGGTVLKG LELMEQGVGA AGLSLGIGTV AAYGSGIGAI YVVLDVVRRG 250
    NLQYFAYYCF LIGGLGLWLL 270
    Length:270
    Mass (Da):28,777
    Last modified:January 24, 2006 - v1
    Checksum:i4396DFD7D9688E18
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000159 Genomic DNA. Translation: ABC44894.1.
    RefSeqiWP_011403116.1. NC_007677.1.
    YP_444483.1. NC_007677.1.

    Genome annotation databases

    EnsemblBacteriaiABC44894; ABC44894; SRU_0337.
    GeneIDi3850899.
    KEGGisru:SRU_0337.
    PATRICi23422997. VBISalRub86502_0350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000159 Genomic DNA. Translation: ABC44894.1 .
    RefSeqi WP_011403116.1. NC_007677.1.
    YP_444483.1. NC_007677.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309807.SRU_0337.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC44894 ; ABC44894 ; SRU_0337 .
    GeneIDi 3850899.
    KEGGi sru:SRU_0337.
    PATRICi 23422997. VBISalRub86502_0350.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi PIVFDIY.
    OrthoDBi EOG6QP13M.
    PhylomeDBi Q2S5P8.

    Enzyme and pathway databases

    BioCyci SRUB309807:GJJD-337-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13855 / M31.

    Entry informationi

    Entry nameiUPPP_SALRD
    AccessioniPrimary (citable) accession number: Q2S5P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3