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Q2S515

- Q2S515_SALRD

UniProt

Q2S515 - Q2S515_SALRD

Protein

Alanine racemase

Gene

alr

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei186 – 1861SubstrateUniRule annotation
    Active sitei316 – 3161Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei364 – 3641Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSRUB309807:GJJD-572-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:SRU_0573Imported
    OrganismiSalinibacter ruber (strain DSM 13855 / M31)Imported
    Taxonomic identifieri309807 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
    ProteomesiUP000008674: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei89 – 891N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi309807.SRU_0573.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2S515.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiRIGISIY.
    OrthoDBiEOG6PP9NJ.
    PhylomeDBiQ2S515.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2S515-1 [UniParc]FASTAAdd to Basket

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    MGCEAGGRGE HVRRAIGAEG FGNHRPGRRL SCACSLIFAR SPVPFAIDRS    50
    PHTVGAAPVT ATVDLAAIRH NAGVLQERAG GADVMAIIKA DAYGHGVRPV 100
    AQAAYEAGIR HYGVARLPEG VHLREAGHGG RILVLGAPAP TQLPRYAEYD 150
    LDLTVSSADV AAAVVRHASP EAPLRVHVTV DTGMGRLGLA PDDVPAVMTR 200
    LADASGVRLA GLWTHFATAD APGSSFAQTQ LDRFRAVVGA VDVDVEHVHA 250
    ANTGGLLTIG APTHEFDASL VRSGIALYGL AATPELSARL DLRPAMRLAA 300
    RVTHLKTVPA GTPISYGAQW EAPRRTRIAT LGIGYGDGYP RRCSGRASVR 350
    IGGASCPIVG TICMDMCMVD LGPPNEAPAT RVDRGDEAVL FGPAGPTAYD 400
    VAQWSDTIPY EILCGVSPRV PRRHVNCTDE NGTDDMRAPS RLTRPTASGG 450
    Length:450
    Mass (Da):47,052
    Last modified:January 24, 2006 - v1
    Checksum:i52CAE22EEA0C2350
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000159 Genomic DNA. Translation: ABC45941.1.
    RefSeqiYP_444716.1. NC_007677.1.

    Genome annotation databases

    EnsemblBacteriaiABC45941; ABC45941; SRU_0573.
    GeneIDi3852801.
    KEGGisru:SRU_0573.
    PATRICi23423495. VBISalRub86502_0597.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000159 Genomic DNA. Translation: ABC45941.1 .
    RefSeqi YP_444716.1. NC_007677.1.

    3D structure databases

    ProteinModelPortali Q2S515.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309807.SRU_0573.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC45941 ; ABC45941 ; SRU_0573 .
    GeneIDi 3852801.
    KEGGi sru:SRU_0573.
    PATRICi 23423495. VBISalRub86502_0597.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi RIGISIY.
    OrthoDBi EOG6PP9NJ.
    PhylomeDBi Q2S515.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci SRUB309807:GJJD-572-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13855 / M31Imported.

    Entry informationi

    Entry nameiQ2S515_SALRD
    AccessioniPrimary (citable) accession number: Q2S515
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3