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Protein

Alanine racemase

Gene

alr

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei186SubstrateUniRule annotation1
Active sitei316Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei364Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:SRU_0573Imported
OrganismiSalinibacter ruber (strain DSM 13855 / M31)Imported
Taxonomic identifieri309807 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
Proteomesi
  • UP000008674 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi309807.SRU_0573.

Structurei

3D structure databases

ProteinModelPortaliQ2S515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 425Ala_racemase_CInterPro annotationAdd BLAST131

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031444.
KOiK01775.
OMAiWEILCGF.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2S515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCEAGGRGE HVRRAIGAEG FGNHRPGRRL SCACSLIFAR SPVPFAIDRS
60 70 80 90 100
PHTVGAAPVT ATVDLAAIRH NAGVLQERAG GADVMAIIKA DAYGHGVRPV
110 120 130 140 150
AQAAYEAGIR HYGVARLPEG VHLREAGHGG RILVLGAPAP TQLPRYAEYD
160 170 180 190 200
LDLTVSSADV AAAVVRHASP EAPLRVHVTV DTGMGRLGLA PDDVPAVMTR
210 220 230 240 250
LADASGVRLA GLWTHFATAD APGSSFAQTQ LDRFRAVVGA VDVDVEHVHA
260 270 280 290 300
ANTGGLLTIG APTHEFDASL VRSGIALYGL AATPELSARL DLRPAMRLAA
310 320 330 340 350
RVTHLKTVPA GTPISYGAQW EAPRRTRIAT LGIGYGDGYP RRCSGRASVR
360 370 380 390 400
IGGASCPIVG TICMDMCMVD LGPPNEAPAT RVDRGDEAVL FGPAGPTAYD
410 420 430 440 450
VAQWSDTIPY EILCGVSPRV PRRHVNCTDE NGTDDMRAPS RLTRPTASGG
Length:450
Mass (Da):47,052
Last modified:January 24, 2006 - v1
Checksum:i52CAE22EEA0C2350
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000159 Genomic DNA. Translation: ABC45941.1.
RefSeqiWP_011403349.1. NC_007677.1.
YP_444716.1. NC_007677.1.

Genome annotation databases

EnsemblBacteriaiABC45941; ABC45941; SRU_0573.
GeneIDi3852801.
KEGGisru:SRU_0573.
PATRICifig|309807.25.peg.597.

Similar proteinsi

Entry informationi

Entry nameiQ2S515_SALRD
AccessioniPrimary (citable) accession number: Q2S515
Entry historyiIntegrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: September 27, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported