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Q2S415

- SYL_SALRD

UniProt

Q2S415 - SYL_SALRD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei638 – 6381ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSRUB309807:GJJD-931-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:SRU_0933
    OrganismiSalinibacter ruber (strain DSM 13855 / M31)
    Taxonomic identifieri309807 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
    ProteomesiUP000008674: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Leucine--tRNA ligasePRO_1000009423Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi309807.SRU_0933.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2S415.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5312"HIGH" regionAdd
    BLAST
    Motifi635 – 6395"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.
    PhylomeDBiQ2S415.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2S415-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYPFHDIET KWQQYWEEHQ TFRTPDEVPD DQEEFYVLDM FPYPSGSGLH    50
    VGHPEGYTAT DIVARYKRKQ GFNVLHPMGW DAFGLPAEQY ALKTNTHPRE 100
    TTEKNIAQFK RQLKRLGFSY DWQREINTTD PDYYKWTQWI FLQLYEKGLA 150
    YQSEEPVWWC EELGTVLANE EVIDGKSERG GYPCERVPMR QWVLKITEYA 200
    DRLLEGLEDL DWPESTKEMQ RNWIGRSEGA NVYFDLVGAD DALEVYTTRP 250
    DTLFGATYMV LAPEHELLDE ITTDEHREDV DEYCRQALRK SERKRQQQGD 300
    KTGVFTGGYA VNPVNGEEIP IWVADYVLVS YGTGAIMAVP AHDERDHAFA 350
    NKYDLPIREV VEGGDIDEEA YTGDGPHVHS ANEAVSLNGL RNEEAKEAIT 400
    EWLDEEEKGE RTVNYQLQDW LFSRQRYWGE PFPIVFTEDG EDKPVPEEEL 450
    PVTLPDLDVF EPSGTPEGPL ATIEDWRETT DPETGEPAQR ETNTMPQWAG 500
    SCWYYLRFID PDNDEQLVDP EKEEYWMPVD LYVGGSEHAV LHLLYARFWH 550
    KVLYDAGVVS TKEPFQTLVH QGMILGETEY TAYRDDAGEF VSAEQVDDDA 600
    DLTPVPVDDG DVKKDGDVFV LADRPAVRVD ARSHKMSKSR GNVINPDDVV 650
    DEYGADTLRL YEMFMGPLEQ DKPWSTDDME GVHRFLNRIW RLVVDADSGG 700
    LAVSDEEPDR EQLRTLHRTI KTVTEDIEAR DFNTAIAAMM EFVNAANKWD 750
    ALPRQVATPF VLLLSPFAPH LAEELWARLG HDQSLAYADW PAYDDELIRR 800
    EVVEMPVQVD GTVRATIEVA ADAEEADVLA TAKEAENVAR HLDDEDLQRE 850
    IYVPGQIVNF VTG 863
    Length:863
    Mass (Da):98,948
    Last modified:January 24, 2006 - v1
    Checksum:iDE2DC62AD14854EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000159 Genomic DNA. Translation: ABC46207.1.
    RefSeqiYP_445066.1. NC_007677.1.

    Genome annotation databases

    EnsemblBacteriaiABC46207; ABC46207; SRU_0933.
    GeneIDi3850817.
    KEGGisru:SRU_0933.
    PATRICi23424243. VBISalRub86502_0967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000159 Genomic DNA. Translation: ABC46207.1 .
    RefSeqi YP_445066.1. NC_007677.1.

    3D structure databases

    ProteinModelPortali Q2S415.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309807.SRU_0933.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC46207 ; ABC46207 ; SRU_0933 .
    GeneIDi 3850817.
    KEGGi sru:SRU_0933.
    PATRICi 23424243. VBISalRub86502_0967.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.
    PhylomeDBi Q2S415.

    Enzyme and pathway databases

    BioCyci SRUB309807:GJJD-931-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13855 / M31.

    Entry informationi

    Entry nameiSYL_SALRD
    AccessioniPrimary (citable) accession number: Q2S415
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3