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Q2S415

- SYL_SALRD

UniProt

Q2S415 - SYL_SALRD

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei638 – 6381ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSRUB309807:GJJD-931-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SRU_0933
OrganismiSalinibacter ruber (strain DSM 13855 / M31)
Taxonomic identifieri309807 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
ProteomesiUP000008674: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Leucine--tRNA ligasePRO_1000009423Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi309807.SRU_0933.

Structurei

3D structure databases

ProteinModelPortaliQ2S415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5312"HIGH" regionAdd
BLAST
Motifi635 – 6395"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.
PhylomeDBiQ2S415.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2S415-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYPFHDIET KWQQYWEEHQ TFRTPDEVPD DQEEFYVLDM FPYPSGSGLH
60 70 80 90 100
VGHPEGYTAT DIVARYKRKQ GFNVLHPMGW DAFGLPAEQY ALKTNTHPRE
110 120 130 140 150
TTEKNIAQFK RQLKRLGFSY DWQREINTTD PDYYKWTQWI FLQLYEKGLA
160 170 180 190 200
YQSEEPVWWC EELGTVLANE EVIDGKSERG GYPCERVPMR QWVLKITEYA
210 220 230 240 250
DRLLEGLEDL DWPESTKEMQ RNWIGRSEGA NVYFDLVGAD DALEVYTTRP
260 270 280 290 300
DTLFGATYMV LAPEHELLDE ITTDEHREDV DEYCRQALRK SERKRQQQGD
310 320 330 340 350
KTGVFTGGYA VNPVNGEEIP IWVADYVLVS YGTGAIMAVP AHDERDHAFA
360 370 380 390 400
NKYDLPIREV VEGGDIDEEA YTGDGPHVHS ANEAVSLNGL RNEEAKEAIT
410 420 430 440 450
EWLDEEEKGE RTVNYQLQDW LFSRQRYWGE PFPIVFTEDG EDKPVPEEEL
460 470 480 490 500
PVTLPDLDVF EPSGTPEGPL ATIEDWRETT DPETGEPAQR ETNTMPQWAG
510 520 530 540 550
SCWYYLRFID PDNDEQLVDP EKEEYWMPVD LYVGGSEHAV LHLLYARFWH
560 570 580 590 600
KVLYDAGVVS TKEPFQTLVH QGMILGETEY TAYRDDAGEF VSAEQVDDDA
610 620 630 640 650
DLTPVPVDDG DVKKDGDVFV LADRPAVRVD ARSHKMSKSR GNVINPDDVV
660 670 680 690 700
DEYGADTLRL YEMFMGPLEQ DKPWSTDDME GVHRFLNRIW RLVVDADSGG
710 720 730 740 750
LAVSDEEPDR EQLRTLHRTI KTVTEDIEAR DFNTAIAAMM EFVNAANKWD
760 770 780 790 800
ALPRQVATPF VLLLSPFAPH LAEELWARLG HDQSLAYADW PAYDDELIRR
810 820 830 840 850
EVVEMPVQVD GTVRATIEVA ADAEEADVLA TAKEAENVAR HLDDEDLQRE
860
IYVPGQIVNF VTG
Length:863
Mass (Da):98,948
Last modified:January 24, 2006 - v1
Checksum:iDE2DC62AD14854EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000159 Genomic DNA. Translation: ABC46207.1.
RefSeqiYP_445066.1. NC_007677.1.

Genome annotation databases

EnsemblBacteriaiABC46207; ABC46207; SRU_0933.
GeneIDi3850817.
KEGGisru:SRU_0933.
PATRICi23424243. VBISalRub86502_0967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000159 Genomic DNA. Translation: ABC46207.1 .
RefSeqi YP_445066.1. NC_007677.1.

3D structure databases

ProteinModelPortali Q2S415.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309807.SRU_0933.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC46207 ; ABC46207 ; SRU_0933 .
GeneIDi 3850817.
KEGGi sru:SRU_0933.
PATRICi 23424243. VBISalRub86502_0967.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.
PhylomeDBi Q2S415.

Enzyme and pathway databases

BioCyci SRUB309807:GJJD-931-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13855 / M31.

Entry informationi

Entry nameiSYL_SALRD
AccessioniPrimary (citable) accession number: Q2S415
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3