Q2S3R7 (EFG_SALRD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor G
Short name=EF-G

Gene names

Name:	fusA
Ordered Locus Names:	SRU_1032

Organism

Salinibacter ruber (strain DSM 13855 / M31)

Taxonomic identifier

309807 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidetes Order II. Incertae sedis › Rhodothermaceae › Salinibacter

Protein attributes

Sequence length	706 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP MF_00054_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00054_B.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 706	706	Elongation factor G HAMAP MF_00054_B		PRO_0000263502
Regions
	Nucleotide binding	21 – 28	8	GTP By similarity
	Nucleotide binding	85 – 89	5	GTP By similarity
	Nucleotide binding	139 – 142	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2S3R7 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 8712554A4D35EC98	FASTA	706	79,105
	10 20 30 40 50 60 MATQTNESFP LEKTRNIGIM AHIDAGKTTL TERILFYTGR LHRMGEVHEG AATMDFMEQE 70 80 90 100 110 120 KERGITITSA ATTCYWDDHR VNIIDTPGHV DFTVEVERSL RVLDGAIALF CAVGGVEPQS 130 140 150 160 170 180 ETVWRQAEKY DVPRIGFVNK MDRTGADFEN VLEMMEDRLS ANPVPVQYPI GAGDMFRGVI 190 200 210 220 230 240 DLIEGKAIIY DDESQGMQWD VREIPDDLES KAEHWRINLL ESVAEYDDEL LMKYLDEDQE 250 260 270 280 290 300 VEPEELHTVI RKATLNRDMT PMFCGSALKN TGVQRVLDGV TNYLPSPNDV PAITGHHPQD 310 320 330 340 350 360 KEEDITRHPR EDEPFSAVAF KITTDPYVGK LTFVRVYSGT LESGSRVYSP TRDEDERIGR 370 380 390 400 410 420 MMFMHADSRE DVDVIRAGDI AAVVGPKNLK TGDTICDPDH PVVLESMDFP EPVIRIAVEP 430 440 450 460 470 480 RTKADRDKLT NGLTKLAEED PTFNVRTDEE TGQTIIAGMG ELHLEIIIDR LKQEFKVEAN 490 500 510 520 530 540 VGQPQVAYRE ALTDMIDEHY VLKKQSGGRG QFAEVYMDVG PIPEEEEEES GLVFENEIKG 550 560 570 580 590 600 GVIPKEFIPS VERGIESAME DGPLAGYPIE GVWVRLYDGD HHEVDSDQNA FEIAGRLGFR 610 620 630 640 650 660 EAARHANPVL MEPVMEVEVV TPDDYMGDII GDLNGRRGQI GQMGQRNDAQ VINAEVPLSE 670 680 690 700 MFGYSTDLRS LSQGRAIYTM QFGSYEPVPE EVASEIMDEQ TMSATA

References

[1]

"The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea." Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H., Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K., Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L., Legault B., Rodriguez-Valera F. Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005) [PubMed: 16330755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13855 / M31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000159 Genomic DNA. Translation: ABC45180.1.
RefSeq	YP_445164.1. NC_007677.1.
3D structure databases
HSSP	HSSP built from PDB template 2EFG based on UniProtKB Q5SHN5.
ProteinModelPortal	Q2S3R7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2S3R7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3851010.
GenomeReviews	Gene locus SRU_1032 in contig CP000159_GR.
KEGG	sru:SRU_1032.
NMPDR	fig|309807.5.peg.966.
PATRIC	23424451. VBISalRub86502_1070.
TIGR	SRU_1032.
Phylogenomic databases
eggNOG	COG0480.
HOGENOM	HBG737692.
OMA	CNEWREK.
PhylomeDB	Q2S3R7.
ProtClustDB	CLSK2774559.
Enzyme and pathway databases
BioCyc	SRUB309807:SRU_1032-MONOMER.
Family and domain databases
HAMAP	MF_00054_B. EF-G_EF-2_B. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR000795. ProtSyn_GTP-bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR004540. Transl_elong_EFG/EF2. IPR000640. Transl_elong_EFG/EF2_C. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.30.70.240. Transl_elong_EFG/EF2_C. 1 hit.
KO	K02355.
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG_SALRD

Accession

Primary (citable) accession number: Q2S3R7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program