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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pykA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41SubstrateUniRule annotation1
Binding sitei123SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Binding sitei207ATPUniRule annotation1
Binding sitei294ATP; via carbonyl oxygenUniRule annotation1
Binding sitei325ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi354 – 357ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSRUB309807:G1G5H-1196-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:SRU_1199
OrganismiSalinibacter ruber (strain DSM 13855 / M31)
Taxonomic identifieri309807 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
Proteomesi
  • UP000008674 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000096461 – 398Phosphoglycerate kinaseAdd BLAST398

Proteomic databases

PRIDEiQ2S3A7

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi309807.SRU_1199

Structurei

3D structure databases

ProteinModelPortaliQ2S3A7
SMRiQ2S3A7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni64 – 67Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q2S3A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKLTLDDVD VRGQRVLIRV DFNVPLDTSE DGSPCVGDDT RIRAALPTIR
60 70 80 90 100
HVLDHGGKAI LVSHLGRPGG QPDPDLSLAC VADHLGTLIE ERVRFSSNTV
110 120 130 140 150
GDTVEEVING MSEGSVILLE NTRFDAGEKA NDEAFATALA NLADVYVNDA
160 170 180 190 200
FGAAHRAHAS TAGVAEFMDV AALGRLMEDE IEALTRVRDD PAHPMVAILG
210 220 230 240 250
GSKVSDKLGT IRALSETADH LLIGGAMSYT FLKVLGHEVG ASRVEADRLD
260 270 280 290 300
TAEDLYEQAE GTITLPTDHV VAEAPEADAT ASVVEGDIPA ELMGLDIGPA
310 320 330 340 350
TIDAYRDRIL GAATVVWNGP MGVFEVDPFA DGTTAIAEAM ADATDDGAFS
360 370 380 390
VVGGGDSVSA LTRSGCDDRI SHVSTGGGAL LTFLEGAPLP GVEALTDA
Length:398
Mass (Da):41,487
Last modified:January 24, 2006 - v1
Checksum:i41C94D8C5B13D2B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000159 Genomic DNA Translation: ABC45859.1
RefSeqiWP_011403952.1, NC_007677.1
YP_445324.1, NC_007677.1

Genome annotation databases

EnsemblBacteriaiABC45859; ABC45859; SRU_1199
GeneIDi3851848
KEGGisru:SRU_1199
PATRICifig|309807.25.peg.1245

Similar proteinsi

Entry informationi

Entry nameiPGK_SALRD
AccessioniPrimary (citable) accession number: Q2S3A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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