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Q2S305 (Q2S305_SALRD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208 EMBL ABC46274.1
Ordered Locus Names:SRU_1302
OrganismSalinibacter ruber (strain DSM 13855 / M31)
Taxonomic identifier309807 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidetes Order II. Incertae sedis › Rhodothermaceae › Salinibacter

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region134 – 14295-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site10715-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site11115-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site11315-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1381Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
Q2S305 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: BED87653D856E431

FASTA22523,740
        10         20         30         40         50         60 
MMSQDLFAPS STDRARALAD ALLSIDAVSL RPHDPFTWSS GLAAPIYCDN RQTLAHPSVR 

        70         80         90        100        110        120 
ERIADGFAEA VREYDGTSLT VAGTATAGIP HAAWLADRIE APMAYVRDSA KGHGQGRRIE 

       130        140        150        160        170        180 
GARPGAGDEV VVVEDLISTG RSALNAAAAV RETGANVSAV LAIFSYGLDA AATAFREAGV 

       190        200        210        220 
PCHVLTTFPV LLDVARRQHS LSADAEALLN DWQADPEAWS HEHGG

« Hide

References

[1]"The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea."
Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H., Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K., Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L., Legault B., Rodriguez-Valera F.
Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005) [PubMed: 16330755] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13855 / M31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000159 Genomic DNA. Translation: ABC46274.1.
RefSeqYP_445426.1. NC_007677.1.

3D structure databases

ProteinModelPortalQ2S305.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2S305.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3852574.
GenomeReviewsGene locus SRU_1302 in contig CP000159_GR.
KEGGsru:SRU_1302.
NMPDRfig|309807.5.peg.1219.
PATRIC23425027. VBISalRub86502_1353.
TIGRSRU_1302.

Phylogenomic databases

eggNOGCOG0461.
HOGENOMHBG404341.
OMALPMTYVR.
PhylomeDBQ2S305.
ProtClustDBCLSK2775291.

Enzyme and pathway databases

BioCycSRUB309807:SRU_1302-MONOMER.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2S305_SALRD
AccessionPrimary (citable) accession number: Q2S305
Entry history
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info