Q2S2F5 (KYNB_SALRD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	SRU_1503

Organism

Salinibacter ruber (strain DSM 13855 / M31)

Taxonomic identifier

309807 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidetes Order II. Incertae sedis › Rhodothermaceae › Salinibacter

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Kynurenine formamidase		PRO_0000362138

Sequences

	Sequence		Length	Mass (Da)
	Q2S2F5 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 8882F8F51EB21EF5	FASTA	212	22,347
	10 20 30 40 50 60 MALIDISRSV SPATAVWPGD QEVQWTWTAR RNEDESSVNL GSLRLSTHTG THVDAPLHVK 70 80 90 100 110 120 RQGQATDDLP LDSFVGPARV VDVNANAPSV RPEHIGQLDG ASAERVLFKT SSGVSPDDEW 130 140 150 160 170 180 PDAVVPIQPD TIHALADAGV SLVGTDAPSV DPLDSTDLPA HHALLDTGIV NLEGLVLTNV 190 200 210 PPGRYELIAL PLKIVGGDAA PVRAVLRDAP DP

References

[1]

"The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea." Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H., Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K., Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L., Legault B., Rodriguez-Valera F. Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005) [PubMed: 16330755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13855 / M31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000159 Genomic DNA. Translation: ABC46272.1.
RefSeq	YP_445626.1. NC_007677.1.
3D structure databases
ProteinModelPortal	Q2S2F5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2S2F5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3852572.
GenomeReviews	Gene locus SRU_1503 in contig CP000159_GR.
KEGG	sru:SRU_1503.
NMPDR	fig|309807.5.peg.1419.
PATRIC	23425441. VBISalRub86502_1559.
TIGR	SRU_1503.
Phylogenomic databases
eggNOG	COG1878.
HOGENOM	HBG686791.
OMA	HTSKWPL.
PhylomeDB	Q2S2F5.
ProtClustDB	CLSK2775289.
Enzyme and pathway databases
BioCyc	SRUB309807:SRU_1503-MONOMER.
Family and domain databases
InterPro	IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KYNB_SALRD

Accession

Primary (citable) accession number: Q2S2F5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program