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Protein

Kynurenine formamidase

Gene

kynB

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.UniRule annotation

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 2 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynurenine formamidase (kynB)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTryptophan catabolism

Enzyme and pathway databases

BioCyciSRUB309807:G1G5H-1500-MONOMER
UniPathwayiUPA00333; UER00454

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:kynBUniRule annotation
Ordered Locus Names:SRU_1503
OrganismiSalinibacter ruber (strain DSM 13855 / M31)
Taxonomic identifieri309807 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
Proteomesi
  • UP000008674 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003621381 – 212Kynurenine formamidaseAdd BLAST212

Interactioni

Protein-protein interaction databases

STRINGi309807.SRU_1503

Structurei

3D structure databases

ProteinModelPortaliQ2S2F5
SMRiQ2S2F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cyclase 1 superfamily. KynB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107XCH Bacteria
COG1878 LUCA
HOGENOMiHOG000219455
KOiK07130
OMAiCPVNVGR
OrthoDBiPOG091H0N8N

Family and domain databases

Gene3Di3.50.30.50, 1 hit
HAMAPiMF_01969 KynB, 1 hit
InterProiView protein in InterPro
IPR007325 KFase
IPR037175 KFase_sf
IPR017484 Kynurenine_formamidase_bac
PfamiView protein in Pfam
PF04199 Cyclase, 1 hit
SUPFAMiSSF102198 SSF102198, 1 hit

Sequencei

Sequence statusi: Complete.

Q2S2F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALIDISRSV SPATAVWPGD QEVQWTWTAR RNEDESSVNL GSLRLSTHTG
60 70 80 90 100
THVDAPLHVK RQGQATDDLP LDSFVGPARV VDVNANAPSV RPEHIGQLDG
110 120 130 140 150
ASAERVLFKT SSGVSPDDEW PDAVVPIQPD TIHALADAGV SLVGTDAPSV
160 170 180 190 200
DPLDSTDLPA HHALLDTGIV NLEGLVLTNV PPGRYELIAL PLKIVGGDAA
210
PVRAVLRDAP DP
Length:212
Mass (Da):22,347
Last modified:January 24, 2006 - v1
Checksum:i8882F8F51EB21EF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000159 Genomic DNA Translation: ABC46272.1
RefSeqiWP_011404252.1, NC_007677.1
YP_445626.1, NC_007677.1

Genome annotation databases

EnsemblBacteriaiABC46272; ABC46272; SRU_1503
GeneIDi3852572
KEGGisru:SRU_1503
PATRICifig|309807.25.peg.1559

Similar proteinsi

Entry informationi

Entry nameiKYNB_SALRD
AccessioniPrimary (citable) accession number: Q2S2F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: January 24, 2006
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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