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Q2S289

- MDH_SALRD

UniProt

Q2S289 - MDH_SALRD

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Protein
Malate dehydrogenase
Gene
mdh, SRU_1571
Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321NAD By similarity
Binding sitei81 – 811Substrate By similarity
Binding sitei87 – 871Substrate By similarity
Binding sitei94 – 941NAD By similarity
Binding sitei119 – 1191Substrate By similarity
Binding sitei150 – 1501Substrate By similarity
Active sitei174 – 1741Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NAD By similarity
Nucleotide bindingi117 – 1193NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSRUB309807:GJJD-1568-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:SRU_1571
OrganismiSalinibacter ruber (strain DSM 13855 / M31)
Taxonomic identifieri309807 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
ProteomesiUP000008674: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Malate dehydrogenaseUniRule annotation
PRO_0000241967Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi309807.SRU_1571.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65
Helixi10 – 2213
Beta strandi25 – 317
Helixi37 – 5216
Beta strandi57 – 648
Helixi65 – 673
Beta strandi71 – 755
Helixi88 – 10619
Beta strandi113 – 1164
Helixi121 – 13212
Helixi136 – 1383
Beta strandi139 – 1413
Helixi144 – 15916
Helixi163 – 1653
Beta strandi166 – 1749
Helixi175 – 1773
Beta strandi178 – 18710
Helixi192 – 1943
Helixi198 – 20912
Helixi211 – 2199
Helixi225 – 24016
Beta strandi244 – 25411
Helixi255 – 2573
Beta strandi259 – 27012
Beta strandi273 – 2775
Helixi284 – 30926

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NEPX-ray1.55X1-314[»]
ProteinModelPortaliQ2S289.
SMRiQ2S289. Positions 1-303.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiLDLMEAQ.
OrthoDBiEOG6091FG.
PhylomeDBiQ2S289.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2S289-1 [UniParc]FASTAAdd to Basket

« Hide

MKVTVIGAGN VGATVAECVA RQDVAKEVVM VDIKDGMPQG KALDMRESSP    50
IHGFDTRVTG TNDYGPTEDS DVCIITAGLP RSPGMSRDDL LAKNTEIVGG 100
VTEQFVEGSP DSTIIVVANP LDVMTYVAYE ASGFPTNRVM GMAGVLDTGR 150
FRSFIAEELD VSVRDVQALL MGGHGDTMVP LPRYTTVGGI PVPQLIDDAR 200
IEEIVERTKG AGGEIVDLMG TSAWYAPGAA AAEMTEAILK DNKRILPCAA 250
YCDGEYGLDD LFIGVPVKLG AGGVEEVIEV DLDADEKAQL KTSAGHVHSN 300
LDDLQRLRDE GKIG 314
Length:314
Mass (Da):33,256
Last modified:January 24, 2006 - v1
Checksum:iFD2F7BDA3F8249E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000159 Genomic DNA. Translation: ABC45135.1.
RefSeqiWP_011404318.1. NC_007677.1.
YP_445692.1. NC_007677.1.

Genome annotation databases

EnsemblBacteriaiABC45135; ABC45135; SRU_1571.
GeneIDi3850691.
KEGGisru:SRU_1571.
PATRICi23425577. VBISalRub86502_1625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000159 Genomic DNA. Translation: ABC45135.1 .
RefSeqi WP_011404318.1. NC_007677.1.
YP_445692.1. NC_007677.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3NEP X-ray 1.55 X 1-314 [» ]
ProteinModelPortali Q2S289.
SMRi Q2S289. Positions 1-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309807.SRU_1571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC45135 ; ABC45135 ; SRU_1571 .
GeneIDi 3850691.
KEGGi sru:SRU_1571.
PATRICi 23425577. VBISalRub86502_1625.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi LDLMEAQ.
OrthoDBi EOG6091FG.
PhylomeDBi Q2S289.

Enzyme and pathway databases

BioCyci SRUB309807:GJJD-1568-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13855 / M31.

Entry informationi

Entry nameiMDH_SALRD
AccessioniPrimary (citable) accession number: Q2S289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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