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Q2S1P1

- PNP_SALRD

UniProt

Q2S1P1 - PNP_SALRD

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi493 – 4931MagnesiumUniRule annotation
    Metal bindingi499 – 4991MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciSRUB309807:GJJD-1770-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:SRU_1773
    OrganismiSalinibacter ruber (strain DSM 13855 / M31)
    Taxonomic identifieri309807 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
    ProteomesiUP000008674: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 712712Polyribonucleotide nucleotidyltransferasePRO_0000329826Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi309807.SRU_1773.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2S1P1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini560 – 62263KHUniRule annotationAdd
    BLAST
    Domaini632 – 70069S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF13014. KH_3. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2S1P1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPEAHIEDI EFVPDRSLSL ETGRIAKQAD GSVVARLGDT MVLSTATLSD    50
    SVNESNFFPL TVDYREKFAA GGKVPGGFIK REGRPTDKET LTSRLIDRAI 100
    RPLFPDGFYH DVHVVNFVIS AGQDFDADVI AGVGSSAALM LSGAPFAGPF 150
    AEVRVGRVDG DYIVNPTMQQ TEESDIDLVV AGKEDALVMV EGEAEEISEE 200
    SMIEALDVAH RSIRRLCEGQ HRLVEQAGEP DPFEWEADRV PEQLVQRMRE 250
    EYGPKVADHI HGPYSKETFH GGIGDLKDQA VDDVLGDASE TPEGYTASDI 300
    RDAIGEVEKG EMRNMIVEEG KRIDGRDQTD VRDLWMEVGY LPRVHGSAIF 350
    TRGETQVLGS ITLGTSDDVQ PVDEVFADTD KSFYLHYRFP PFSVGEASYL 400
    RGPKRREIGH SMLAERALRP VIPEQDEFPY TIRINADVME SNGSSSMASV 450
    CAGSLALMDA GVPIEKPVAG IAMGLVQEDD ETTVLTDILG QEDHLGDMDF 500
    KLTGTRDGIT ACQMDMKIEG LSRDVMLKAL KQSRDARHHI LDRMEETIAE 550
    PRAELSSHAP RLTKLTIDPD RIGAVIGPGG KVVKSVQEET NTEITVEEEE 600
    GVGIVTIAAT NQRDAEAAIE RIKQIVAVPE EGEDYVGTVK GIRDFGAFVE 650
    IMPEKTGLLH VSEIDYDYVE NVEDYLEVGD KVKVHLLEVH DDGKMRLTRK 700
    PFVSEENGEQ NE 712
    Length:712
    Mass (Da):78,371
    Last modified:April 29, 2008 - v2
    Checksum:iEA6B4BCF729CF22C
    GO

    Sequence cautioni

    The sequence ABC44372.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000159 Genomic DNA. Translation: ABC44372.1. Different initiation.
    RefSeqiYP_445890.1. NC_007677.1.

    Genome annotation databases

    EnsemblBacteriaiABC44372; ABC44372; SRU_1773.
    GeneIDi3851405.
    KEGGisru:SRU_1773.
    PATRICi23426017. VBISalRub86502_1841.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000159 Genomic DNA. Translation: ABC44372.1 . Different initiation.
    RefSeqi YP_445890.1. NC_007677.1.

    3D structure databases

    ProteinModelPortali Q2S1P1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309807.SRU_1773.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC44372 ; ABC44372 ; SRU_1773 .
    GeneIDi 3851405.
    KEGGi sru:SRU_1773.
    PATRICi 23426017. VBISalRub86502_1841.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci SRUB309807:GJJD-1770-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF13014. KH_3. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13855 / M31.

    Entry informationi

    Entry nameiPNP_SALRD
    AccessioniPrimary (citable) accession number: Q2S1P1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3