Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q2S1L8

- SYE_SALRD

UniProt

Q2S1L8 - SYE_SALRD

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (30 May 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei258 – 2581ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSRUB309807:GJJD-1794-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:SRU_1796
    OrganismiSalinibacter ruber (strain DSM 13855 / M31)
    Taxonomic identifieri309807 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
    ProteomesiUP000008674: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Glutamate--tRNA ligasePRO_0000237398Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi309807.SRU_1796.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2S1L8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi13 – 2311"HIGH" regionAdd
    BLAST
    Motifi255 – 2595"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252720.
    KOiK01885.
    OrthoDBiEOG6DRPF7.
    PhylomeDBiQ2S1L8.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2S1L8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASDAPVRVR FAPSPTGRLH IGGLRTALYN YLFARKHDGD FVLRIEDTDQ    50
    ARYEPGAEDD IREALAWTGL EHDEGPEQGG DYAPYRQSER SEHYHEYAQK 100
    LVEAGRAYYA FDTEEELEEL REEHGAYDGS TRRQMRNSLT LSDEKVEQRI 150
    DEGDDYVIRL KVPRQESVQV EDEIRGTVSF DTSEIDDQVL VKSDGMPTYH 200
    LANIVDDHLM NISHVIRGEE WLSSTPKHVL MYDALGWEPP AFAHLPLILS 250
    PNGGKLSKRD ANELGIPVYV MDYREAGYEP EALLNFLALL GWSPGTEEEL 300
    FALDEMVETF SLDRVGASGV QFDLDKLRWV NEHYVRALSV DALAEKARPH 350
    VEAAGYDVSD DRLQTICGLV QDRIQVVPEV VTDNRYFFED PEAYEEAGVE 400
    KRWNEESADL LLAYADRLEG VDAFDTDTVE TELRDLADEK DVGAGAIIHP 450
    SRLAVSGRSY GPGVFGLLAA VGKEACIRRM HRAVEALG 488
    Length:488
    Mass (Da):54,926
    Last modified:May 30, 2006 - v2
    Checksum:i08A6D9EF6C11EDA8
    GO

    Sequence cautioni

    The sequence ABC45991.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000159 Genomic DNA. Translation: ABC45991.1. Different initiation.
    RefSeqiYP_445913.1. NC_007677.1.

    Genome annotation databases

    EnsemblBacteriaiABC45991; ABC45991; SRU_1796.
    GeneIDi3852853.
    KEGGisru:SRU_1796.
    PATRICi23426067. VBISalRub86502_1866.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000159 Genomic DNA. Translation: ABC45991.1 . Different initiation.
    RefSeqi YP_445913.1. NC_007677.1.

    3D structure databases

    ProteinModelPortali Q2S1L8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309807.SRU_1796.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC45991 ; ABC45991 ; SRU_1796 .
    GeneIDi 3852853.
    KEGGi sru:SRU_1796.
    PATRICi 23426067. VBISalRub86502_1866.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252720.
    KOi K01885.
    OrthoDBi EOG6DRPF7.
    PhylomeDBi Q2S1L8.

    Enzyme and pathway databases

    BioCyci SRUB309807:GJJD-1794-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13855 / M31.

    Entry informationi

    Entry nameiSYE_SALRD
    AccessioniPrimary (citable) accession number: Q2S1L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3