Q2S1I3 (PCKA1_SALRD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoenolpyruvate carboxykinase [ATP] 1
Short name=PEP carboxykinase 1
Short name=PEPCK
EC=4.1.1.49

Alternative name(s):
Phosphoenolpyruvate carboxylase 1

Gene names

Name:	pckA1
Ordered Locus Names:	SRU_1835

Organism

Salinibacter ruber (strain DSM 13855 / M31)

Taxonomic identifier

309807 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidetes Order II. Incertae sedis › Rhodothermaceae › Salinibacter

Protein attributes

Sequence length	535 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2. HAMAP MF_00453
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00453
Subcellular location	Cytoplasm By similarity HAMAP MF_00453.
Sequence similarities	Belongs to the phosphoenolpyruvate carboxykinase [ATP] family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoenolpyruvate carboxykinase (ATP) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 535	535	Phosphoenolpyruvate carboxykinase [ATP] 1 HAMAP MF_00453		PRO_0000236938
Regions
	Nucleotide binding	234 – 241	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2S1I3 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: EBB75A3AB2C54126	FASTA	535	58,886
	10 20 30 40 50 60 MPLPNHVTSH LRSLQLAPAA VHYNLKRPRL YEEALDRNEG QLAAGGPLVT RTAPYTGRSP 70 80 90 100 110 120 KDRFIVRDAS VADQINWGEV NQPTDRATFD HLHERMAEHA EGRDLFVQDL HAGWDESYRL 130 140 150 160 170 180 PVRIITEKAW HSLFARNMFV RPDGPVPDSF EPGFTVVDLC EFEADPERDG THSEAAVFVD 190 200 210 220 230 240 IAQNLILIGG THYGGEIKKS IFSVLNYMLP EEGVLPMHCS ANEGEDGDTA VFFGLSGTGK 250 260 270 280 290 300 TTLSADASRT LIGDDEHGWS DRGVYNFEGG CYAKMIDITP ESEPEIHGTT EEFGTILENV 310 320 330 340 350 360 IVDPDTREPD FSDDTITQNT RGSYPLHYIP NTSSDGRGGH PDHVLFLTYD AFGVLPPVSE 370 380 390 400 410 420 LSPAQAMYHF LSGYTAKVAG TEAGVNEPKA TFSTCFGEPF MVRDPSVYAE LLGQKIRRHD 430 440 450 460 470 480 TDCWLVNTGM TGGPYGVGHR IELDHTRAMV DAILDGTLGT VARTRDPVFG LSIPDRVPGV 490 500 510 520 530 PDSVLTPRQT WGDPQAYDQH ARELVDAFAD NFETYVEQVG TEVRAAGPSL ETIRG

References

[1]

"The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea." Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H., Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K., Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L., Legault B., Rodriguez-Valera F. Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005) [PubMed: 16330755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13855 / M31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000159 Genomic DNA. Translation: ABC44749.1.
RefSeq	YP_445948.1. NC_007677.1.
3D structure databases
ProteinModelPortal	Q2S1I3.
SMR	Q2S1I3. Positions 11-531.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2S1I3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3851043.
GenomeReviews	Gene locus SRU_1835 in contig CP000159_GR.
KEGG	sru:SRU_1835.
NMPDR	fig|309807.5.peg.1734.
PATRIC	23426147. VBISalRub86502_1902.
TIGR	SRU_1835.
Phylogenomic databases
eggNOG	COG1866.
HOGENOM	HBG293387.
OMA	FAQDLYG.
PhylomeDB	Q2S1I3.
ProtClustDB	PRK09344.
Enzyme and pathway databases
BioCyc	SRUB309807:SRU_1835-MONOMER.
Family and domain databases
HAMAP	MF_00453. PEPCK_ATP. [Tree]
InterPro	IPR001272. PEP_carboxykinase_ATP. IPR013035. PEP_carboxykinase_C. IPR008210. PEP_carboxykinase_N. IPR015994. PEPCK_ATP_CS. [Graphical view]
Gene3D	G3DSA:3.90.228.20. PEP_carboxykinase_C. 2 hits. G3DSA:3.40.449.10. PEP_carboxykinase_N. 1 hit.
KO	K01610.
Pfam	PF01293. PEPCK_ATP. 1 hit. [Graphical view]
PIRSF	PIRSF006294. PEP_crbxkin. 1 hit.
SUPFAM	SSF68923. PEP_carboxykinase_N. 1 hit.
TIGRFAMs	TIGR00224. PckA. 1 hit.
PROSITE	PS00532. PEPCK_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PCKA1_SALRD

Accession

Primary (citable) accession number: Q2S1I3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program