Q2S1H7 (SURE_SALRD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	SRU_1842

Organism

Salinibacter ruber (strain DSM 13855 / M31)

Taxonomic identifier

309807 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidetes Order II. Incertae sedis › Rhodothermaceae › Salinibacter

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	5'-nucleotidase surE HAMAP MF_00060		PRO_0000235646
Sites
	Metal binding	17	1	Divalent metal cation By similarity
	Metal binding	18	1	Divalent metal cation By similarity
	Metal binding	48	1	Divalent metal cation By similarity
	Metal binding	107	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2S1H7 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 5847F4A3C906043A	FASTA	272	29,108
	10 20 30 40 50 60 MSSPASGDEP RILLCNDDGI HAPGIQSLAS ALDGLGELFV VAPTTEQSAV GHAITVRDPV 70 80 90 100 110 120 RAHREEFEVP SGPIPAWGVT GTPADSVKLA CHELLDAPPD LVVSGINQGP NTAVNVLYSG 130 140 150 160 170 180 TVSAATEASI LGLDSLAISL CEWSKPQFEV AGQWARRIVE WALDRGLPQG VLLNVNVPAL 190 200 210 220 230 240 SAEQIEGVAL TRQARSRWEE GFERRTDPAD RPYYWLAGTF VNLDDGPETD LSAIERGYVS 250 260 270 VTPIQHDMTA HDAFEAFGTW DWDESAGPDG SE

References

[1]

"The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea." Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H., Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K., Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L., Legault B., Rodriguez-Valera F. Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005) [PubMed: 16330755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13855 / M31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000159 Genomic DNA. Translation: ABC46336.1.
RefSeq	YP_445954.1. NC_007677.1.
3D structure databases
ProteinModelPortal	Q2S1H7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2S1H7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3851139.
GenomeReviews	Gene locus SRU_1842 in contig CP000159_GR.
KEGG	sru:SRU_1842.
NMPDR	fig|309807.5.peg.1740.
PATRIC	23426163. VBISalRub86502_1909.
TIGR	SRU_1842.
Phylogenomic databases
eggNOG	COG0496.
HOGENOM	HBG600532.
OMA	NINIPEN.
PhylomeDB	Q2S1H7.
ProtClustDB	CLSK2775336.
Enzyme and pathway databases
BioCyc	SRUB309807:SRU_1842-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_SALRD

Accession

Primary (citable) accession number: Q2S1H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program