Q2S122 (Q2S122_SALRD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Inorganic pyrophosphatase HAMAP MF_00209
EC=3.6.1.1 HAMAP MF_00209

Alternative name(s):
Pyrophosphate phospho-hydrolase HAMAP MF_00209

Gene names

Name:	ppa HAMAP MF_00209 EMBL ABC45287.1
Ordered Locus Names:	SRU_2000

Organism

Salinibacter ruber (strain DSM 13855 / M31)

Taxonomic identifier

309807 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidetes Order II. Incertae sedis › Rhodothermaceae › Salinibacter

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP MF_00209
Cofactor	Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity. HAMAP MF_00209
Subcellular location	Cytoplasm By similarity HAMAP MF_00209.
Sequence similarities	Belongs to the PPase family. HAMAP MF_00209

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00209
Ligand	Magnesium HAMAP MF_00209 Metal-binding HAMAP MF_00209
Molecular function	Hydrolase HAMAP MF_00209 EMBL ABC45287.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phosphate-containing compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inorganic diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	67	1	Magnesium 1 By similarity HAMAP MF_00209
	Metal binding	72	1	Magnesium 1 By similarity HAMAP MF_00209
	Metal binding	72	1	Magnesium 2 By similarity HAMAP MF_00209
	Metal binding	104	1	Magnesium 1 By similarity HAMAP MF_00209

Sequences

	Sequence		Length	Mass (Da)
	Q2S122 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 91F29EC3AE101E76	FASTA	181	20,794
	10 20 30 40 50 60 MSHPWHDIAV GGEAPDMFSC IIEIPQGCKV KYELDKESGL LRVDRMLHSS VVYPANYGFI 70 80 90 100 110 120 PRTYADDGDP LDMLVLAQES VDPLSILRAR PIGLMNMLDD DEEDAKIICI HLDDPAFNDY 130 140 150 160 170 180 WHIKELPDHR LRELRRFFQD YKALEDKTVQ VKDFFGPDRA KGIVDGALQR YEEEIAPMRD G

References

[1]

"The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea." Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H., Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K., Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L., Legault B., Rodriguez-Valera F. Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005) [PubMed: 16330755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13855 / M31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000159 Genomic DNA. Translation: ABC45287.1.
RefSeq	YP_446109.1. NC_007677.1.
3D structure databases
ProteinModelPortal	Q2S122.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2S122.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3852163.
GenomeReviews	Gene locus SRU_2000 in contig CP000159_GR.
KEGG	sru:SRU_2000.
NMPDR	fig|309807.5.peg.1893.
PATRIC	23426507. VBISalRub86502_2078.
TIGR	SRU_2000.
Phylogenomic databases
eggNOG	COG0221.
HOGENOM	HBG529150.
OMA	PNDFNVI.
PhylomeDB	Q2S122.
ProtClustDB	CLSK755313.
Enzyme and pathway databases
BioCyc	SRUB309807:SRU_2000-MONOMER.
Family and domain databases
HAMAP	MF_00209. Inorganic_PPase. [Tree]
InterPro	IPR008162. Pyrophosphatase. [Graphical view]
Gene3D	G3DSA:3.90.80.10. Pyrophosphatase. 1 hit.
KO	K01507.
PANTHER	PTHR10286. Pyrophosphatase. 1 hit.
Pfam	PF00719. Pyrophosphatase. 1 hit. [Graphical view]
SUPFAM	SSF50324. Pyrophosphatase. 1 hit.
PROSITE	PS00387. PPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2S122_SALRD

Accession

Primary (citable) accession number: Q2S122

Entry history

Integrated into UniProtKB/TrEMBL:	January 24, 2006
Last sequence update:	January 24, 2006
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)