Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciSRUB309807:G1G5H-2069-MONOMER
UniPathwayiUPA00253; UER00332

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotation
Ordered Locus Names:SRU_2072
OrganismiSalinibacter ruber (strain DSM 13855 / M31)
Taxonomic identifieri309807 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
Proteomesi
  • UP000008674 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000718391 – 195Probable nicotinate-nucleotide adenylyltransferaseAdd BLAST195

Proteomic databases

PRIDEiQ2S0V3

Interactioni

Protein-protein interaction databases

STRINGi309807.SRU_2072

Structurei

3D structure databases

ProteinModelPortaliQ2S0V3
SMRiQ2S0V3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z1W Bacteria
COG1057 LUCA
HOGENOMiHOG000262780
KOiK00969
OMAiIHIGHLI
OrthoDBiPOG091H028Y

Family and domain databases

CDDicd02165 NMNAT, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00244 NaMN_adenylyltr, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR005248 NadD/NMNAT
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00482 TIGR00482, 1 hit

Sequencei

Sequence statusi: Complete.

Q2S0V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVGLFGGSF NPPHVAHLVV AEVVRDQFGL DEVWWIPNAT PPHKPNDELA
60 70 80 90 100
AVQHRLAMTE RTVEGNPAFR VCGVEVERDG VSYTVETLRV LQDQHPDTDF
110 120 130 140 150
ALILGSDSLD HFADWHRPDE IAERVPFIVY KRPGAIESVA DPRFVNDVRY
160 170 180 190
AAAPVMEISG TEVRARRRAG RSIRYLVPEA VRAYIDTHDL YRPTD
Length:195
Mass (Da):21,981
Last modified:January 24, 2006 - v1
Checksum:i303E755408A5E6A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000159 Genomic DNA Translation: ABC45500.1
RefSeqiWP_011404800.1, NC_007677.1
YP_446178.1, NC_007677.1

Genome annotation databases

EnsemblBacteriaiABC45500; ABC45500; SRU_2072
GeneIDi3852730
KEGGisru:SRU_2072
PATRICifig|309807.25.peg.2156

Similar proteinsi

Entry informationi

Entry nameiNADD_SALRD
AccessioniPrimary (citable) accession number: Q2S0V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health