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Q2S032 (Q2S032_SALRD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha HAMAP MF_00823
Short name=ACCase subunit alpha HAMAP MF_00823
Short name=Acetyl-CoA carboxylase carboxyltransferase subunit alpha HAMAP MF_00823
EC=6.4.1.2 HAMAP MF_00823
Gene names
Name:accA HAMAP MF_00823 EMBL ABC43565.1
Ordered Locus Names:SRU_2348
OrganismSalinibacter ruber (strain DSM 13855 / M31)
Taxonomic identifier309807 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidetes Order II. Incertae sedis › Rhodothermaceae › Salinibacter

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA By similarity. HAMAP MF_00823 SAAS SAAS011763

Catalytic activity

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. HAMAP MF_00823 SAAS SAAS011763

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. HAMAP MF_00823 SAAS SAAS011763

Subunit structure

Acetyl-CoA carboxylase is an heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD) By similarity. HAMAP MF_00823 SAAS SAAS011763

Subcellular location

Cytoplasm By similarity HAMAP MF_00823 SAAS SAAS011763.

Sequence similarities

Belongs to the AccA family. HAMAP MF_00823

Sequences

Sequence LengthMass (Da)Tools
Q2S032 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 619ECD00571A8194

FASTA33537,526
        10         20         30         40         50         60 
MADDEHLLDF EKPLVELEDK LTEMRELNAE TQDDLSNEIE ALEERVEQLR TSIYRNLTRW 

        70         80         90        100        110        120 
QRVQIARHPE RPYTLDHIEA LTEDFTELRG DRKFGDDRSI VGGLAQFTGS RFGYRDRTVM 

       130        140        150        160        170        180 
IMGHQKGRDT KERKYRRFGM PNPEGYRKAE RLMKMAAKFG KPVVVLLDTP GAYPGMGAEE 

       190        200        210        220        230        240 
RGQAEAIAHN LFEMARLETP VVIVVIGEGA SGGALGVGLG DRILMLENAW YSVIAPESCS 

       250        260        270        280        290        300 
QILWRSWDHK EDAAQALKLT ATDLTEVGIV DEIVPEPVGG AHRDPQRTYQ AVGAAVAEAL 

       310        320        330 
DELEDLDPQA LLDQRLEKFD ALGAYESAEP MTASA

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References

[1]"The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea."
Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H., Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K., Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L., Legault B., Rodriguez-Valera F.
Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005) [PubMed: 16330755] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13855 / M31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000159 Genomic DNA. Translation: ABC43565.1.
RefSeqYP_446449.1. NC_007677.1.

3D structure databases

ProteinModelPortalQ2S032.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2S032.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3852462.
GenomeReviewsGene locus SRU_2348 in contig CP000159_GR.
KEGGsru:SRU_2348.
NMPDRfig|309807.5.peg.2221.
PATRIC23427251. VBISalRub86502_2445.
TIGRSRU_2348.

Phylogenomic databases

eggNOGCOG0825.
HOGENOMHBG286557.
OMAGRDTKDN.
PhylomeDBQ2S032.
ProtClustDBPRK05724.

Enzyme and pathway databases

BioCycSRUB309807:SRU_2348-MONOMER.

Family and domain databases

HAMAPMF_00823. AcetylCoA_CT_alpha.
[Tree]
InterProIPR001095. Acetyl_CoA_COase_a_su.
IPR011763. COA_CT_C.
[Graphical view]
KOK01962.
PANTHERPTHR22855:SF3. Ac-CoA_carboxylA. 1 hit.
PfamPF03255. ACCA. 1 hit.
[Graphical view]
PRINTSPR01069. ACCCTRFRASEA.
TIGRFAMsTIGR00513. AccA. 1 hit.
PROSITEPS50989. COA_CT_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ2S032_SALRD
AccessionPrimary (citable) accession number: Q2S032
Entry history
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info