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Protein

Catalase-peroxidase

Gene

katG

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei88Transition state stabilizerUniRule annotation1
Active sitei92Proton acceptorUniRule annotation1
Metal bindingi255Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3063. SruCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:SRU_2405
OrganismiSalinibacter ruber (strain DSM 13855 / M31)
Taxonomic identifieri309807 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
Proteomesi
  • UP000008674 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003549011 – 729Catalase-peroxidaseAdd BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki91 ↔ 214Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-240)UniRule annotation
Cross-linki214 ↔ 240Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ2RZX7.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi309807.SRU_2405.

Structurei

3D structure databases

ProteinModelPortaliQ2RZX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2RZX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNGSNGSVE QRDSMPETSR EWWPGSLDVE ILDQNAQDVG PWNGDFDYAE
60 70 80 90 100
AFQELDYEAL KEDIEEVMTT SKDWWPADYG HYGPLFIRMS WHAAGTYRTT
110 120 130 140 150
DGRGGSSGGR QRLAPLNSWP DNANLDKARR LLWPVKQKYG RKISWADLLV
160 170 180 190 200
LAGNVAMESM GFETFGFAGG REDDFKPDES IDWGPEDEME TWGRFNEEDE
210 220 230 240 250
LDNPLGATVM GLIYVNPEGP ESTPDPEWSA QRIRKSFGRM AMNDRETAAL
260 270 280 290 300
IAGGHTFGKV HGADTDEHLQ AEPEAAPIEQ QGLGWHNEHG SGKGGDTITS
310 320 330 340 350
GIEGPWTDAP TEWDMGYLDF LLDYEWEVHK GPGGAWQWRP KSDELKGVVP
360 370 380 390 400
DAHDASETVD PMMLTTDVAL KRDPDYREII EDFRENPDAF EDAFARAWFK
410 420 430 440 450
LLHRDMGPKE RYLGPEVPEE DLIWQDPVPD ADHDLIGDEE IAELKEAILE
460 470 480 490 500
TDLSVSRLVK TAWASASTYR DSDKRGGANG ARIRLEPHRN WEANEPPQLA
510 520 530 540 550
HALEVLTGIQ KNFNDARTDD VRVSLADLIV LGGSAAIEKA AADAGHDVEV
560 570 580 590 600
PFTPGRTDAT QEQTDVEAFE YLEPKADGFR NYIADDPWQD WTPEEFLVDK
610 620 630 640 650
ADLLNLTPAE TTVLVGGMRA LDATHEQADG YGVFTDRPET LNNDYFVNLL
660 670 680 690 700
DMGHEWDPVS EDKQHFKIRD RDTGEVKWKA TRVDLIFGSN SRFRALSQVY
710 720
GSGDAEEKFV DDFVDAWTKV MNLDRFDLE
Length:729
Mass (Da):82,038
Last modified:January 24, 2006 - v1
Checksum:i4D127EFC5C88E187
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000159 Genomic DNA. Translation: ABC45695.1.
RefSeqiWP_011405122.1. NC_007677.1.
YP_446504.1. NC_007677.1.

Genome annotation databases

EnsemblBacteriaiABC45695; ABC45695; SRU_2405.
GeneIDi3851567.
KEGGisru:SRU_2405.
PATRICi23427373. VBISalRub86502_2505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000159 Genomic DNA. Translation: ABC45695.1.
RefSeqiWP_011405122.1. NC_007677.1.
YP_446504.1. NC_007677.1.

3D structure databases

ProteinModelPortaliQ2RZX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi309807.SRU_2405.

Protein family/group databases

PeroxiBasei3063. SruCP01.

Proteomic databases

PRIDEiQ2RZX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC45695; ABC45695; SRU_2405.
GeneIDi3851567.
KEGGisru:SRU_2405.
PATRICi23427373. VBISalRub86502_2505.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_SALRD
AccessioniPrimary (citable) accession number: Q2RZX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.