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Q2RZH4 (KITH_SALRD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:SRU_2559
OrganismSalinibacter ruber (strain DSM 13855 / M31) [Reference proteome] [HAMAP]
Taxonomic identifier309807 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Thymidine kinase HAMAP-Rule MF_00124
PRO_0000242802

Regions

Nucleotide binding15 – 228ATP By similarity
Nucleotide binding87 – 904ATP By similarity

Sites

Active site881Proton acceptor Potential
Metal binding1441Zinc By similarity
Metal binding1471Zinc By similarity
Metal binding1761Zinc By similarity
Metal binding1791Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2RZH4 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 51934C486650BDDA

FASTA22724,876
        10         20         30         40         50         60 
MDRDRTTGWM EVICGSMFSG KTEELIRRLR RARIARQHTR VFKPALDERY SEDEVVSHNE 

        70         80         90        100        110        120 
NSVTTTPVEA PPQIQELVQE ADVVGIDEAQ FFDDDLVPTC QALAEDGHRV IVVGLDTDYR 

       130        140        150        160        170        180 
AEPFDPMPQL MAVAEHVTKL HAVCVVCGAP ANHSQRIVPG EDRVLVGATE AYEPRCRACF 

       190        200        210        220 
EPEPVTVTRP RPHTEALRAV ATDDADASTN EADPEAADAA SADGTAA 

« Hide

References

[1]"The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea."
Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H., Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K., Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L., Legault B., Rodriguez-Valera F.
Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13855 / M31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000159 Genomic DNA. Translation: ABC45345.1.
RefSeqYP_446657.1. NC_007677.1.

3D structure databases

ProteinModelPortalQ2RZH4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309807.SRU_2559.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC45345; ABC45345; SRU_2559.
GeneID3851644.
KEGGsru:SRU_2559.
PATRIC23427697. VBISalRub86502_2666.

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076390.
KOK00857.
OMADHISEST.
OrthoDBEOG69D3J2.
PhylomeDBQ2RZH4.

Enzyme and pathway databases

BioCycSRUB309807:GJJD-2556-MONOMER.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_SALRD
AccessionPrimary (citable) accession number: Q2RZH4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 24, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families