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Q2RZH4

- KITH_SALRD

UniProt

Q2RZH4 - KITH_SALRD

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Protein

Thymidine kinase

Gene
tdk, SRU_2559
Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptor Reviewed prediction
Metal bindingi144 – 1441Zinc By similarity
Metal bindingi147 – 1471Zinc By similarity
Metal bindingi176 – 1761Zinc By similarity
Metal bindingi179 – 1791Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP By similarity
Nucleotide bindingi87 – 904ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSRUB309807:GJJD-2556-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:SRU_2559
OrganismiSalinibacter ruber (strain DSM 13855 / M31)
Taxonomic identifieri309807 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
ProteomesiUP000008674: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Thymidine kinaseUniRule annotationPRO_0000242802Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi309807.SRU_2559.

Structurei

3D structure databases

ProteinModelPortaliQ2RZH4.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiDHISEST.
OrthoDBiEOG69D3J2.
PhylomeDBiQ2RZH4.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2RZH4-1 [UniParc]FASTAAdd to Basket

« Hide

MDRDRTTGWM EVICGSMFSG KTEELIRRLR RARIARQHTR VFKPALDERY    50
SEDEVVSHNE NSVTTTPVEA PPQIQELVQE ADVVGIDEAQ FFDDDLVPTC 100
QALAEDGHRV IVVGLDTDYR AEPFDPMPQL MAVAEHVTKL HAVCVVCGAP 150
ANHSQRIVPG EDRVLVGATE AYEPRCRACF EPEPVTVTRP RPHTEALRAV 200
ATDDADASTN EADPEAADAA SADGTAA 227
Length:227
Mass (Da):24,876
Last modified:January 24, 2006 - v1
Checksum:i51934C486650BDDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000159 Genomic DNA. Translation: ABC45345.1.
RefSeqiWP_011405271.1. NC_007677.1.
YP_446657.1. NC_007677.1.

Genome annotation databases

EnsemblBacteriaiABC45345; ABC45345; SRU_2559.
GeneIDi3851644.
KEGGisru:SRU_2559.
PATRICi23427697. VBISalRub86502_2666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000159 Genomic DNA. Translation: ABC45345.1 .
RefSeqi WP_011405271.1. NC_007677.1.
YP_446657.1. NC_007677.1.

3D structure databases

ProteinModelPortali Q2RZH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309807.SRU_2559.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC45345 ; ABC45345 ; SRU_2559 .
GeneIDi 3851644.
KEGGi sru:SRU_2559.
PATRICi 23427697. VBISalRub86502_2666.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi DHISEST.
OrthoDBi EOG69D3J2.
PhylomeDBi Q2RZH4.

Enzyme and pathway databases

BioCyci SRUB309807:GJJD-2556-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13855 / M31.

Entry informationi

Entry nameiKITH_SALRD
AccessioniPrimary (citable) accession number: Q2RZH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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