Q2RZH4 (KITH_SALRD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	tdk
Ordered Locus Names:	SRU_2559

Organism

Salinibacter ruber (strain DSM 13855 / M31)

Taxonomic identifier

309807 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidetes Order II. Incertae sedis › Rhodothermaceae › Salinibacter

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP MF_00124
Subunit structure	Homotetramer By similarity. HAMAP MF_00124
Subcellular location	Cytoplasm Potential HAMAP MF_00124.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Thymidine kinase HAMAP MF_00124		PRO_0000242802
Regions
	Nucleotide binding	15 – 22	8	ATP By similarity
	Nucleotide binding	87 – 90	4	ATP By similarity
Sites
	Active site	88	1	Proton acceptor Potential
	Metal binding	144	1	Zinc By similarity
	Metal binding	147	1	Zinc By similarity
	Metal binding	176	1	Zinc By similarity
	Metal binding	179	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2RZH4 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 51934C486650BDDA	FASTA	227	24,876
	10 20 30 40 50 60 MDRDRTTGWM EVICGSMFSG KTEELIRRLR RARIARQHTR VFKPALDERY SEDEVVSHNE 70 80 90 100 110 120 NSVTTTPVEA PPQIQELVQE ADVVGIDEAQ FFDDDLVPTC QALAEDGHRV IVVGLDTDYR 130 140 150 160 170 180 AEPFDPMPQL MAVAEHVTKL HAVCVVCGAP ANHSQRIVPG EDRVLVGATE AYEPRCRACF 190 200 210 220 EPEPVTVTRP RPHTEALRAV ATDDADASTN EADPEAADAA SADGTAA

References

[1]

"The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea." Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H., Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K., Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L., Legault B., Rodriguez-Valera F. Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005) [PubMed: 16330755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13855 / M31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000159 Genomic DNA. Translation: ABC45345.1.
RefSeq	YP_446657.1. NC_007677.1.
3D structure databases
ProteinModelPortal	Q2RZH4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2RZH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3851644.
GenomeReviews	Gene locus SRU_2559 in contig CP000159_GR.
KEGG	sru:SRU_2559.
NMPDR	fig|309807.5.peg.2418.
PATRIC	23427697. VBISalRub86502_2666.
TIGR	SRU_2559.
Phylogenomic databases
eggNOG	COG1435.
HOGENOM	HBG522108.
OMA	EPRCRHH.
PhylomeDB	Q2RZH4.
ProtClustDB	CLSK2774678.
Enzyme and pathway databases
BioCyc	SRUB309807:SRU_2559-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase. [Tree]
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
KO	K00857.
PANTHER	PTHR11441. TK_cell. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_SALRD

Accession

Primary (citable) accession number: Q2RZH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program