Reviewed, UniProtKB/Swiss-Prot Q2RYH3 (UPPP1_RHORT)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Ordered Locus Names:	Rru_A0017

Organism

Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255) [Complete proteome] [HAMAP]

Taxonomic identifier

269796 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000250258
Regions
	Transmembrane	1 – 21	21	Potential
	Transmembrane	46 – 66	21	Potential
	Transmembrane	91 – 111	21	Potential
	Transmembrane	117 – 137	21	Potential
	Transmembrane	150 – 170	21	Potential
	Transmembrane	193 – 213	21	Potential
	Transmembrane	226 – 246	21	Potential
	Transmembrane	260 – 280	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2RYH3-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 629AEA2194B2B7AE	FASTA	282	29,284
	10 20 30 40 50 60 MLLLQIVVLA LIQGITEVLP LSSTGHLALL PLLTPWPSPT TWPDQGVALD VAVHLGTLGA 70 80 90 100 110 120 VALYFWRDEA AMIGGCLRLL KGKRDPGARL AFLVVLGTLP AVATVLLLAH FAGPIASPGL 130 140 150 160 170 180 ATIGWTTLGF GLLLGVIDRL CMTVKRVEHM GGIDCLLIGL AQCLALLPGV SRTGVAMTAA 190 200 210 220 230 240 RLLGYERVES ARFSMLLSIP AIAGAATLVG LDLARVGQSA MAPAALIAAV TAFLAAFLAV 250 260 270 280 AAMMAWLRRH GFGPFVAYRV LLGAALLALA YLGPDLAPFL VS

References

[1]

"Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000230 Genomic DNA. Translation: ABC20822.1.
RefSeq	YP_425109.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2RYH3.
Genome annotation databases
GeneID	3833905.
GenomeReviews	Gene locus Rru_A0017 in contig CP000230_GR.
KEGG	rru:Rru_A0017.
NMPDR	fig|1085.1.peg.1097.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	AVSAYIC.
Enzyme and pathway databases
BioCyc	RRUB269796:RRU_A0017-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP1_RHORT

Accession

Primary (citable) accession number: Q2RYH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	January 24, 2006
Last modified:	January 19, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)