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Protein

Adenine deaminase

Gene

Rru_A0766

Organism
Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.UniRule annotation

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17Zinc; catalyticUniRule annotation1
Metal bindingi19Zinc; catalyticUniRule annotation1
Metal bindingi197Zinc; catalyticUniRule annotation1
Active sitei200Proton donorUniRule annotation1
Sitei221Important for catalytic activityUniRule annotation1
Metal bindingi278Zinc; catalyticUniRule annotation1
Binding sitei279SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciRRUB269796:GCN1-781-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
ADEUniRule annotation
Alternative name(s):
Adenine aminohydrolaseUniRule annotation
Short name:
AAHUniRule annotation
Gene namesi
Ordered Locus Names:Rru_A0766
OrganismiRhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Taxonomic identifieri269796 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
Proteomesi
  • UP000001929 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000819301 – 334Adenine deaminaseAdd BLAST334

Interactioni

Protein-protein interaction databases

STRINGi269796.Rru_A0766

Structurei

3D structure databases

ProteinModelPortaliQ2RWC5
SMRiQ2RWC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EKD Bacteria
COG1816 LUCA
HOGENOMiHOG000218813
KOiK21053
OMAiRGWFRFQ
OrthoDBiPOG091H02QG

Family and domain databases

CDDicd01320 ADA, 1 hit
HAMAPiMF_01962 Adenine_deaminase, 1 hit
InterProiView protein in InterPro
IPR001365 A/AMP_deaminase_dom
IPR028892 ADE
IPR006330 Ado/ade_deaminase
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01430 aden_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q2RWC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDPAFLHA LPKVELHLHI EGSLEPEMMV ALAERNGLRL PYASVEAVRA
60 70 80 90 100
AYDFQNLQDF LDLYYQGMAV LRTERDFEDL AMAYFQRAAA QNVLHAEIFF
110 120 130 140 150
DPQGHTARGV ALEAVIAGLT SARKRAEAEL GVSSELILSF LRHLSEEEAF
160 170 180 190 200
ATLEEALPHR DQFIGVGLDS SEVGHPPAKF ARVFARARAE GLRLVAHAGE
210 220 230 240 250
EGPPDYVREA LDLLAIDRLD HGNRALEDEA LIERLIAEGM ALTVCPLSNL
260 270 280 290 300
KLRVVDDLGA HPLKAMLERG LKATINSDDP SYFGGYMLEN MAAVAEALAL
310 320 330
ETHHLRTLTA NAIDASFASP ARKAEMHARL AAVN
Length:334
Mass (Da):36,593
Last modified:January 24, 2006 - v1
Checksum:i84087F9873D48192
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000230 Genomic DNA Translation: ABC21570.1
RefSeqiWP_011388524.1, NC_007643.1
YP_425857.1, NC_007643.1

Genome annotation databases

EnsemblBacteriaiABC21570; ABC21570; Rru_A0766
GeneIDi3834175
KEGGirru:Rru_A0766
PATRICifig|269796.9.peg.819

Similar proteinsi

Entry informationi

Entry nameiADE_RHORT
AccessioniPrimary (citable) accession number: Q2RWC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health