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Protein

Adenine deaminase

Gene

Rru_A0766

Organism
Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.UniRule annotation

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Zinc; catalyticUniRule annotation
Metal bindingi19 – 191Zinc; catalyticUniRule annotation
Metal bindingi197 – 1971Zinc; catalyticUniRule annotation
Active sitei200 – 2001Proton donorUniRule annotation
Sitei221 – 2211Important for catalytic activityUniRule annotation
Metal bindingi278 – 2781Zinc; catalyticUniRule annotation
Binding sitei279 – 2791SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciRRUB269796:GCN1-781-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
ADEUniRule annotation
Alternative name(s):
Adenine aminohydrolaseUniRule annotation
Short name:
AAHUniRule annotation
Gene namesi
Ordered Locus Names:Rru_A0766
OrganismiRhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Taxonomic identifieri269796 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
Proteomesi
  • UP000001929 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Adenine deaminasePRO_1000081930Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269796.Rru_A0766.

Structurei

3D structure databases

ProteinModelPortaliQ2RWC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218813.
KOiK01488.
OMAiTRVMHES.
OrthoDBiEOG6BPDDD.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2RWC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDPAFLHA LPKVELHLHI EGSLEPEMMV ALAERNGLRL PYASVEAVRA
60 70 80 90 100
AYDFQNLQDF LDLYYQGMAV LRTERDFEDL AMAYFQRAAA QNVLHAEIFF
110 120 130 140 150
DPQGHTARGV ALEAVIAGLT SARKRAEAEL GVSSELILSF LRHLSEEEAF
160 170 180 190 200
ATLEEALPHR DQFIGVGLDS SEVGHPPAKF ARVFARARAE GLRLVAHAGE
210 220 230 240 250
EGPPDYVREA LDLLAIDRLD HGNRALEDEA LIERLIAEGM ALTVCPLSNL
260 270 280 290 300
KLRVVDDLGA HPLKAMLERG LKATINSDDP SYFGGYMLEN MAAVAEALAL
310 320 330
ETHHLRTLTA NAIDASFASP ARKAEMHARL AAVN
Length:334
Mass (Da):36,593
Last modified:January 24, 2006 - v1
Checksum:i84087F9873D48192
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000230 Genomic DNA. Translation: ABC21570.1.
RefSeqiWP_011388524.1. NC_007643.1.
YP_425857.1. NC_007643.1.

Genome annotation databases

EnsemblBacteriaiABC21570; ABC21570; Rru_A0766.
GeneIDi3834175.
KEGGirru:Rru_A0766.
PATRICi23325107. VBIRhoRub82919_0819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000230 Genomic DNA. Translation: ABC21570.1.
RefSeqiWP_011388524.1. NC_007643.1.
YP_425857.1. NC_007643.1.

3D structure databases

ProteinModelPortaliQ2RWC5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269796.Rru_A0766.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC21570; ABC21570; Rru_A0766.
GeneIDi3834175.
KEGGirru:Rru_A0766.
PATRICi23325107. VBIRhoRub82919_0819.

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218813.
KOiK01488.
OMAiTRVMHES.
OrthoDBiEOG6BPDDD.

Enzyme and pathway databases

BioCyciRRUB269796:GCN1-781-MONOMER.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1.

Entry informationi

Entry nameiADE_RHORT
AccessioniPrimary (citable) accession number: Q2RWC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 24, 2006
Last modified: November 11, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.