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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRRUB269796:GCN1-1621-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
Short name:
(3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
Gene namesi
Name:fabZUniRule annotation
Ordered Locus Names:Rru_A1596
OrganismiRhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Taxonomic identifieri269796 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
Proteomesi
  • UP000001929 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1601603-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZPRO_0000230832Add
BLAST

Proteomic databases

PRIDEiQ2RTZ9.

Interactioni

Protein-protein interaction databases

STRINGi269796.Rru_A1596.

Structurei

3D structure databases

ProteinModelPortaliQ2RTZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YXN. Bacteria.
COG0764. LUCA.
HOGENOMiHOG000277829.
KOiK02372.
OrthoDBiEOG6JTCGM.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2RTZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQADPQENQV RTTVDIARII DMIPHRYPFL MVDKLIDMVR GESAIGIKNV
60 70 80 90 100
TINEPFFQGH FPNRPVMPGV LIVEAMAQTA AVLVVETLGV RAEGKIVYFM
110 120 130 140 150
IVENARFRKP VIPGDQLRLH VAKERHRGNV WKFRGVAKVD EVVVAEATFA
160
AMIMDEEPQP
Length:160
Mass (Da):18,046
Last modified:April 4, 2006 - v2
Checksum:i3F4AA81B17711689
GO

Sequence cautioni

The sequence ABC22396.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000230 Genomic DNA. Translation: ABC22396.1. Different initiation.
RefSeqiYP_426683.1. NC_007643.1.

Genome annotation databases

EnsemblBacteriaiABC22396; ABC22396; Rru_A1596.
GeneIDi3835013.
KEGGirru:Rru_A1596.
PATRICi23326832. VBIRhoRub82919_1670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000230 Genomic DNA. Translation: ABC22396.1. Different initiation.
RefSeqiYP_426683.1. NC_007643.1.

3D structure databases

ProteinModelPortaliQ2RTZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269796.Rru_A1596.

Proteomic databases

PRIDEiQ2RTZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC22396; ABC22396; Rru_A1596.
GeneIDi3835013.
KEGGirru:Rru_A1596.
PATRICi23326832. VBIRhoRub82919_1670.

Phylogenomic databases

eggNOGiENOG4108YXN. Bacteria.
COG0764. LUCA.
HOGENOMiHOG000277829.
KOiK02372.
OrthoDBiEOG6JTCGM.

Enzyme and pathway databases

BioCyciRRUB269796:GCN1-1621-MONOMER.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1.

Entry informationi

Entry nameiFABZ_RHORT
AccessioniPrimary (citable) accession number: Q2RTZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 11, 2015
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.