Reviewed, UniProtKB/Swiss-Prot Q2RTE2 (UPPP2_RHORT)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Ordered Locus Names:	Rru_A1803

Organism

Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255) [Complete proteome] [HAMAP]

Taxonomic identifier

269796 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000250259
Regions
	Transmembrane	47 – 64	18	Potential
	Transmembrane	82 – 102	21	Potential
	Transmembrane	110 – 130	21	Potential
	Transmembrane	185 – 205	21	Potential
	Transmembrane	219 – 239	21	Potential
	Transmembrane	249 – 269	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2RTE2-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 1D3EFC52D0925FE6	FASTA	274	29,878
	10 20 30 40 50 60 MDLVMLIKAA ILGLVEGITE FLPISSTGHL IIAGSLLDFL DEQKRDVFVI VIQLGAILAV 70 80 90 100 110 120 CWEYRRRLTD VVAGLGSDPQ SWKFVTNLLI AFLPAVVLGL TFGKAIKAHL FSPVPVATAF 130 140 150 160 170 180 IVGGLVILWA ERRRHPIRVR EVDEMTWVDA LKIGLAQCFA LIPGTSRSGA TIIGGLFFGL 190 200 210 220 230 240 SRKAATEFSF FLAIPTLTAA SLYDLYKNRA LLDGDMSGLM AVGFVVSFLS ALVAVRGLIR 250 260 270 YISRHDFTVF AWYRIAFGLV VLATAWSGLV SWSA

References

[1]

"Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000230 Genomic DNA. Translation: ABC22603.1.
RefSeq	YP_426890.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2RTE2.
Genome annotation databases
GeneID	3835227.
GenomeReviews	Gene locus Rru_A1803 in contig CP000230_GR.
KEGG	rru:Rru_A1803.
NMPDR	fig|1085.1.peg.2377.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2RTE2.
OMA	RWLLRYI.
Enzyme and pathway databases
BioCyc	RRUB269796:RRU_A1803-MON.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_RHORT

Accession

Primary (citable) accession number: Q2RTE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	January 24, 2006
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)