Q2RST6 (GLPK_RHORT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol kinase
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK

Gene names

Name:	glpK
Ordered Locus Names:	Rru_A2009

Organism

Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)

Taxonomic identifier

269796 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	Glycerol kinase HAMAP MF_00186		PRO_1000118555
Regions
	Nucleotide binding	408 – 412	5	ATP By similarity
Sites
	Binding site	11	1	Substrate By similarity
	Binding site	15	1	ATP By similarity
	Binding site	81	1	Substrate By similarity
	Binding site	133	1	Substrate By similarity
	Binding site	242	1	Substrate By similarity
	Binding site	264	1	ATP By similarity
	Binding site	307	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2RST6 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 4B3D2833ED78D71E	FASTA	495	53,274
	10 20 30 40 50 60 MPFLLAIDQG TTSSRAIVFD HEGQPIARAQ KDLVQYFPGD GWVEHDATAI WEDSLAVARE 70 80 90 100 110 120 ALDRADVAAH AISAIGLTNQ RETAVLWERA SGQPVHNAIV WQDRRTAALC RELKAQGHEA 130 140 150 160 170 180 LVRRKTGLLI DPYFSATKIG WMLDHDPVLR RRAEAGELAF GTVESWLLYK LTGGAVHASD 190 200 210 220 230 240 ATNAARTLLF DIRANRWDED LLALFRIPAA LLPRVVDNAG RFGETLPGLF GAPIPITGMA 250 260 270 280 290 300 GDQHAAMVGQ GCFTRGMIKS TYGTGAFALL NIGQTFVESR NQLLTTLAYR LNGQSTYALE 310 320 330 340 350 360 GSIFVAGAAV QWLRDGLRAI SSAAETQVLA EAVADTGGCY MVPAFTGLGA PYWDPEARGA 370 380 390 400 410 420 ILGLTRDTSL EQVARAALEA QGYQTRDLLD AMAADSGTKP LALRVDGGMV ANDWVCQFLA 430 440 450 460 470 480 DITGIAVERP RVIETTALGA AALAGLGAGV FASPADLGGQ WHRDRLFTPH MPASRRESLY 490 AGWVQAVRRV ASDLR

References

[1]

"Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 11170 / NCIB 8255.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000230 Genomic DNA. Translation: ABC22809.1.
RefSeq	YP_427096.1. NC_007643.1.
3D structure databases
ProteinModelPortal	Q2RST6.
SMR	Q2RST6. Positions 3-491.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2RST6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3835434.
GenomeReviews	Gene locus Rru_A2009 in contig CP000230_GR.
KEGG	rru:Rru_A2009.
NMPDR	fig|1085.1.peg.2584.
PATRIC	23327692. VBIRhoRub82919_2093.
Phylogenomic databases
eggNOG	COG0554.
HOGENOM	HBG511469.
OMA	CYQTRDL.
PhylomeDB	Q2RST6.
Enzyme and pathway databases
BioCyc	RRUB269796:RRU_A2009-MONOMER.
Family and domain databases
HAMAP	MF_00186. Glycerol_kin. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
KO	K00864.
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. Glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. False negative. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK_RHORT

Accession

Primary (citable) accession number: Q2RST6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program