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Protein

NAD(P) transhydrogenase subunit beta

Gene

pntB

Organism
Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.By similarity

Catalytic activityi

NADPH + NAD+ = NADP+ + NADH.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciRRUB269796:GCN1-2216-MONOMER.
BRENDAi1.6.1.2. 5420.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P) transhydrogenase subunit beta (EC:1.6.1.2)
Alternative name(s):
Nicotinamide nucleotide transhydrogenase subunit beta
Proton-translocating transhydrogenase NADP(H)-binding component
Pyridine nucleotide transhydrogenase subunit beta
dIII
Gene namesi
Name:pntB
Synonyms:nntB
Ordered Locus Names:Rru_A2181
OrganismiRhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Taxonomic identifieri269796 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
Proteomesi
  • UP000001929 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464NAD(P) transhydrogenase subunit betaPRO_0000231665Add
BLAST

Interactioni

Subunit structurei

Complex of an alpha and a beta chain; in Rhodospirillum, the alpha chain seems to be made of two subunits.By similarity

Protein-protein interaction databases

STRINGi269796.Rru_A2181.

Structurei

Secondary structure

1
464
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi297 – 3059Combined sources
Beta strandi308 – 3147Combined sources
Helixi316 – 3216Combined sources
Helixi324 – 33613Combined sources
Beta strandi340 – 3456Combined sources
Beta strandi350 – 3523Combined sources
Helixi355 – 3628Combined sources
Helixi367 – 3693Combined sources
Beta strandi370 – 3723Combined sources
Helixi373 – 3764Combined sources
Helixi377 – 3826Combined sources
Beta strandi384 – 3907Combined sources
Helixi393 – 3953Combined sources
Helixi397 – 3993Combined sources
Beta strandi403 – 4053Combined sources
Turni406 – 4094Combined sources
Helixi415 – 4173Combined sources
Beta strandi418 – 42811Combined sources
Helixi438 – 4403Combined sources
Beta strandi445 – 4506Combined sources
Helixi452 – 46312Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E3TNMR-A262-464[»]
1HZZX-ray2.50C262-464[»]
1NM5X-ray2.40C262-464[»]
1PNOX-ray2.10A/B294-464[»]
1PNQX-ray2.40A/B294-464[»]
1PTJX-ray2.61C291-464[»]
1U28X-ray2.30C262-464[»]
1U2DX-ray3.00C262-464[»]
1U2GX-ray2.20C262-464[»]
1XLTX-ray3.10C/F/I294-464[»]
ProteinModelPortaliQ2RSB4.
SMRiQ2RSB4. Positions 290-464.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2RSB4.

Family & Domainsi

Sequence similaritiesi

Belongs to the PNT beta subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C15. Bacteria.
COG1282. LUCA.
HOGENOMiHOG000243958.
KOiK00325.
OMAiILTEIMC.
OrthoDBiPOG091H03IN.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR012136. NADH_DH_b.
[Graphical view]
PfamiPF02233. PNTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000204. PNTB. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2RSB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHSLTMAAY IVAGVLFILA LRGLSNPESA RNGNRMGMVG MAIAILTTLL
60 70 80 90 100
SPSVQAYAWI VLAIAIGGAI GTVIAKKVLM TALPQLVAAF HSLVGMAAVL
110 120 130 140 150
VATGALLNPE AYGIGSAGAI HAGSLVEMSL GLAVGAITFS GSVIAFGKLQ
160 170 180 190 200
GLIAGKPVTF PMQHPLNAVL GILLVVLLVV FAATESHTAY FALMILAFAL
210 220 230 240 250
GFLLIIPIGG ADMPVVISML NSYSGWAAAG IGFTLGNPLL IIAGALVGSS
260 270 280 290 300
GAILSYIMCK GMNRSIFNVI LGGFGSEGGV AAAGGAAGDR SVKAGSAEDA
310 320 330 340 350
AFIMKNASKV IIVPGYGMAV AQAQHALREM ADVLKKEGVE VSYAIHPVAG
360 370 380 390 400
RMPGHMNVLL AEANVPYDEV FELEEINSSF QTADVAFVIG ANDVTNPAAK
410 420 430 440 450
TDPSSPIYGM PILDVEKAGT VLFIKRSMAS GYAGVENELF FRNNTMMLFG
460
DAKKMTEQIV QAMN
Length:464
Mass (Da):47,808
Last modified:January 24, 2006 - v1
Checksum:i79200D4F8861779B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05294 Genomic DNA. Translation: AAA62495.1.
CP000230 Genomic DNA. Translation: ABC22981.1.
RefSeqiWP_011390030.1. NC_007643.1.
YP_427268.1. NC_007643.1.

Genome annotation databases

EnsemblBacteriaiABC22981; ABC22981; Rru_A2181.
GeneIDi3835608.
KEGGirru:Rru_A2181.
PATRICi23328060. VBIRhoRub82919_2275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05294 Genomic DNA. Translation: AAA62495.1.
CP000230 Genomic DNA. Translation: ABC22981.1.
RefSeqiWP_011390030.1. NC_007643.1.
YP_427268.1. NC_007643.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E3TNMR-A262-464[»]
1HZZX-ray2.50C262-464[»]
1NM5X-ray2.40C262-464[»]
1PNOX-ray2.10A/B294-464[»]
1PNQX-ray2.40A/B294-464[»]
1PTJX-ray2.61C291-464[»]
1U28X-ray2.30C262-464[»]
1U2DX-ray3.00C262-464[»]
1U2GX-ray2.20C262-464[»]
1XLTX-ray3.10C/F/I294-464[»]
ProteinModelPortaliQ2RSB4.
SMRiQ2RSB4. Positions 290-464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269796.Rru_A2181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC22981; ABC22981; Rru_A2181.
GeneIDi3835608.
KEGGirru:Rru_A2181.
PATRICi23328060. VBIRhoRub82919_2275.

Phylogenomic databases

eggNOGiENOG4105C15. Bacteria.
COG1282. LUCA.
HOGENOMiHOG000243958.
KOiK00325.
OMAiILTEIMC.
OrthoDBiPOG091H03IN.

Enzyme and pathway databases

BioCyciRRUB269796:GCN1-2216-MONOMER.
BRENDAi1.6.1.2. 5420.

Miscellaneous databases

EvolutionaryTraceiQ2RSB4.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR012136. NADH_DH_b.
[Graphical view]
PfamiPF02233. PNTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000204. PNTB. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPNTB_RHORT
AccessioniPrimary (citable) accession number: Q2RSB4
Secondary accession number(s): Q59763, Q59765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.