Q2RSB3 (PNTAB_RHORT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P) transhydrogenase subunit alpha part 2
EC=1.6.1.2

Alternative name(s):
Nicotinamide nucleotide transhydrogenase subunit alpha 2
Proton-translocating transhydrogenase component 2
Pyridine nucleotide transhydrogenase subunit alpha 2
dII

Gene names

Name:	pntAB
Synonyms:	nntA2
Ordered Locus Names:	Rru_A2182

Organism

Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)

Taxonomic identifier

269796 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane By similarity.
Catalytic activity	NADPH + NAD+ = NADP+ + NADH.
Subunit structure	Complex of an alpha and a beta chain; in Rhodospirillum, the alpha chain seems to be made of two subunits By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD(P)+ transhydrogenase (AB-specific) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 139	139	NAD(P) transhydrogenase subunit alpha part 2		PRO_0000231664
Regions
	Transmembrane	49 – 69	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	107 – 127	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2RSB3 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 04742D87817A8879	FASTA	139	14,889
	10 20 30 40 50 60 MEDKNILVEG FNQLSQQALE LSQHAQALAL QASHAVLPAA AATEGASEFW WLMTVFVLAC 70 80 90 100 110 120 FIGFYVVWSV TPALHSPLMG VTNAISSVIV VGALIATGPE AFSASKVLGF FAILLASVNI 130 FGGFIVTQRM LAMFKKKQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of the genes for the proton-translocating nicotinamide nucleotide transhydrogenase from Rhodospirillum rubrum and the implications for the domain structure of the enzyme." Williams R., Cotton N.P., Thomas C.M., Jackson J.B. Microbiology 140:1595-1604(1994) [PubMed: 8075801] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 11170 / NCIB 8255.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U05294 Genomic DNA. Translation: AAA62494.1. CP000230 Genomic DNA. Translation: ABC22982.1.
RefSeq	YP_427269.1. NC_007643.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2RSB3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3835609.
GenomeReviews	Gene locus Rru_A2182 in contig CP000230_GR.
KEGG	rru:Rru_A2182.
NMPDR	fig|1085.1.peg.3657.
PATRIC	23328062. VBIRhoRub82919_2276.
Phylogenomic databases
eggNOG	COG3288.
HOGENOM	HBG289734.
OMA	EGASEFW.
PhylomeDB	Q2RSB3.
ProtClustDB	CLSK2397385.
Enzyme and pathway databases
BioCyc	RRUB269796:RRU_A2182-MONOMER.
Family and domain databases
InterPro	IPR024605. NADP_transhyd_a_C. [Graphical view]
KO	K00324.
Pfam	PF12769. DUF3814. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PNTAB_RHORT

Accession

Primary (citable) accession number: Q2RSB3
Secondary accession number(s): Q59762, Q59764

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program