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Q2RSB2 (PNTAA_RHORT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NAD(P) transhydrogenase subunit alpha part 1
EC=1.6.1.2
Alternative name(s):
Nicotinamide nucleotide transhydrogenase subunit alpha 1
Proton-translocating transhydrogenase component 1
Pyridine nucleotide transhydrogenase subunit alpha 1
dI
Gene names
Name:pntAA
Synonyms:nntA1
Ordered Locus Names:Rru_A2183
OrganismRhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Taxonomic identifier269796 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane By similarity.

Catalytic activity

NADPH + NAD+ = NADP+ + NADH.

Subunit structure

Complex of an alpha and a beta chain; in Rhodospirillum, the alpha chain seems to be made of two subunits By similarity.

Sequence similarities

Belongs to the AlaDH/PNT family.

Ontologies

Keywords
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionNAD(P)+ transhydrogenase (AB-specific) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384NAD(P) transhydrogenase subunit alpha part 1
PRO_0000231663

Regions

Nucleotide binding167 – 19731NAD By similarity

Secondary structure

1 ...................................................................... 384
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q2RSB2 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: B886A640CE2BFA12

FASTA38440,277
        10         20         30         40         50         60 
MKIAIPKERR PGEDRVAISP EVVKKLVGLG FEVIVEQGAG VGASITDDAL TAAGATIAST 

        70         80         90        100        110        120 
AAQALSQADV VWKVQRPMTA EEGTDEVALI KEGAVLMCHL GALTNRPVVE ALTKRKITAY 

       130        140        150        160        170        180 
AMELMPRISR AQSMDILSSQ SNLAGYRAVI DGAYEFARAF PMMMTAAGTV PPARVLVFGV 

       190        200        210        220        230        240 
GVAGLQAIAT AKRLGAVVMA TDVRAATKEQ VESLGGKFIT VDDEAMKTAE TAGGYAKEMG 

       250        260        270        280        290        300 
EEFRKKQAEA VLKELVKTDI AITTALIPGK PAPVLITEEM VTKMKPGSVI IDLAVEAGGN 

       310        320        330        340        350        360 
CPLSEPGKIV VKHGVKIVGH TNVPSRVAAD ASPLFAKNLL NFLTPHVDKD TKTLVMKLED 

       370        380 
ETVSGTCVTR DGAIVHPALT GQGA

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of the genes for the proton-translocating nicotinamide nucleotide transhydrogenase from Rhodospirillum rubrum and the implications for the domain structure of the enzyme."
Williams R., Cotton N.P., Thomas C.M., Jackson J.B.
Microbiology 140:1595-1604(1994) [PubMed: 8075801] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C.
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 11170 / NCIB 8255.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U05294 Genomic DNA. Translation: AAA62493.1.
CP000230 Genomic DNA. Translation: ABC22983.1.
RefSeqYP_427270.1. NC_007643.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1F8GX-ray2.00A/B/C/D1-384[»]
1HZZX-ray2.50A/B1-384[»]
1L7DX-ray1.81A/B/C/D1-384[»]
1L7EX-ray1.90A/B/C/D1-384[»]
1NM5X-ray2.40A/B1-384[»]
1PTJX-ray2.61A/B1-381[»]
1U28X-ray2.30A/B1-384[»]
1U2DX-ray3.00A/B1-384[»]
1U2GX-ray2.20A/B1-384[»]
1XLTX-ray3.10A/B/D/E/G/H1-384[»]
ProteinModelPortalQ2RSB2.
SMRQ2RSB2. Positions 1-380.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2RSB2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3835610.
GenomeReviewsGene locus Rru_A2183 in contig CP000230_GR.
KEGGrru:Rru_A2183.
NMPDRfig|1085.1.peg.3658.
PATRIC23328064. VBIRhoRub82919_2277.

Phylogenomic databases

eggNOGCOG3288.
HOGENOMHBG289735.
OMARNVADIL.
PhylomeDBQ2RSB2.

Enzyme and pathway databases

BioCycRRUB269796:RRU_A2183-MONOMER.

Family and domain databases

InterProIPR008142. Ala_DH/PNT_CS1.
IPR008143. Ala_DH/PNT_CS2.
IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
[Graphical view]
KOK00324.
PfamPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
SMARTSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
PROSITEPS00836. ALADH_PNT_1. 1 hit.
PS00837. ALADH_PNT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePNTAA_RHORT
AccessionPrimary (citable) accession number: Q2RSB2
Secondary accession number(s): Q60164
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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