Q2RR29 (DXS2_RHORT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase 2
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 2
Short name=DXP synthase 2
Short name=DXPS 2

Gene names

Name:	dxs2
Ordered Locus Names:	Rru_A2619

Organism

Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)

Taxonomic identifier

269796 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum

Protein attributes

Sequence length	645 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 645	645	1-deoxy-D-xylulose-5-phosphate synthase 2 HAMAP MF_00315		PRO_0000256474

Sequences

	Sequence		Length	Mass (Da)
	Q2RR29 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 13A41BA0A605F3D4	FASTA	645	68,164
	10 20 30 40 50 60 MTSRPITPLL DTIRGPSDTR GLSVAQLEQL AREVRAEMID AVSVTGGHLG SGLGVVELTV 70 80 90 100 110 120 ALHHVFDTPD DRIIWDVGHQ CYPHKILTGR RDRIRTLRQG GGLSGFTLRE ESPYDPFGAG 130 140 150 160 170 180 HSSTSISAGL GMAIGSALAG DARDVVAVIG DGSMSAGMAY EAMNNAGAAK SRLIVILNDN 190 200 210 220 230 240 DMSIAPPVGA MSAYLSRLLS SKSWLSIRTL AKEIVARLPD ALERTAKRAE EYARGMVTGG 250 260 270 280 290 300 GTLFEEMGFY YVGPIDGHRM DHLVPVLRNV REAGRDGPVL IHVVTQKGKG YAPAENAPDK 310 320 330 340 350 360 YHGVSRFNVV TGVQEKAKPQ APSYTAVFGK QLVAAAAKDH RIVAVTAAMP GGTGLDKLAA 370 380 390 400 410 420 AYPQRCFDVG IAEQHAVTFA AGLACEGLKP FVALYSSFLQ RGYDQVVHDV VLQKLPVRFA 430 440 450 460 470 480 IDRAGFVGAD GATHGGVFDM AFLGCLPNLV VMCAADEAEL ARMVVTAAGH DSGPIALRYP 490 500 510 520 530 540 RGEGVGVEIP EDPQPLAIGK GRIVREGKGV ALLSIGTRLQ SCLEACEILA ARGLTPTVAD 550 560 570 580 590 600 ARFLKPFDEE LVADLAARHE VLIVVEEGAI GGFCSHVATW LANQGLLDGG LKLRALHIPD 610 620 630 640 RFFEHDAPEV QCAKAGIDAQ AITTAVLDAL KLETSATIDA GALKA

References

[1]

"Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 11170 / NCIB 8255.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000230 Genomic DNA. Translation: ABC23416.1.
RefSeq	YP_427703.1. NC_007643.1.
3D structure databases
ProteinModelPortal	Q2RR29.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2RR29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3836054.
GenomeReviews	Gene locus Rru_A2619 in contig CP000230_GR.
KEGG	rru:Rru_A2619.
NMPDR	fig|1085.1.peg.270.
PATRIC	23328982. VBIRhoRub82919_2729.
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	EAMNAHA.
PhylomeDB	Q2RR29.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	RRUB269796:RRU_A2619-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR011766. TPP_enzyme-bd_C. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02775. TPP_enzyme_C. 1 hit. PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS2_RHORT

Accession

Primary (citable) accession number: Q2RR29

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program