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Q2RQM7

- HISX_RHORT

UniProt

Q2RQM7 - HISX_RHORT

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Protein
Histidinol dehydrogenase
Gene
hisD, Rru_A2771
Organism
Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NAD By similarity
Binding sitei191 – 1911NAD By similarity
Binding sitei214 – 2141NAD By similarity
Binding sitei237 – 2371Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Active sitei328 – 3281Proton acceptor By similarity
Active sitei329 – 3291Proton acceptor By similarity
Binding sitei329 – 3291Substrate By similarity
Metal bindingi362 – 3621Zinc By similarity
Binding sitei362 – 3621Substrate By similarity
Binding sitei416 – 4161Substrate By similarity
Metal bindingi421 – 4211Zinc By similarity
Binding sitei421 – 4211Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciRRUB269796:GCN1-2819-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Rru_A2771
OrganismiRhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Taxonomic identifieri269796 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
ProteomesiUP000001929: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Histidinol dehydrogenaseUniRule annotation
PRO_0000229865Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269796.Rru_A2771.

Structurei

3D structure databases

ProteinModelPortaliQ2RQM7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiGFLFHAN.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2RQM7-1 [UniParc]FASTAAdd to Basket

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MPLRLEASSA DFAPAFAALL AGKRESAQDV NDVVSAILAD VRLRGDDALI    50
DYTARFDKMT VSAEGLRFSD DEVDTAVALI EPALRDALAL AAKRITRFHE 100
RQMPTAISFT DEDGVRLGQR WTAVSAAGLY VPGGLAAYPS SVLMNALPAK 150
VAGVERLVMV VPTPAGRINP LVLAAAKLAG VDEIYRVGGA QAVAALAYGT 200
RTIAPVDKIV GPGNAYVAAA KRQVFGTVGI DMIAGPSEIL VVADGANDPD 250
WIALDLLSQA EHDAAAQSIL ITDDRAFADR VERAVTDRLR TLSRTEIASA 300
SWRDHGAIIL VGDLLRDAPA LVDKVAPEHL ELAVADPDAL AARVRHAGAI 350
FLGRYTPEAI GDYIAGPNHV LPTSRTARFS SGLGVLDFMK RTTLVGCGAE 400
SLGAIGPSAV RLARAEGLEA HGLSVAARMN RGWE 434
Length:434
Mass (Da):45,648
Last modified:January 24, 2006 - v1
Checksum:iBB30BB3A879BB054
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000230 Genomic DNA. Translation: ABC23568.1.
RefSeqiYP_427855.1. NC_007643.1.

Genome annotation databases

EnsemblBacteriaiABC23568; ABC23568; Rru_A2771.
GeneIDi3836211.
KEGGirru:Rru_A2771.
PATRICi23329288. VBIRhoRub82919_2877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000230 Genomic DNA. Translation: ABC23568.1 .
RefSeqi YP_427855.1. NC_007643.1.

3D structure databases

ProteinModelPortali Q2RQM7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 269796.Rru_A2771.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC23568 ; ABC23568 ; Rru_A2771 .
GeneIDi 3836211.
KEGGi rru:Rru_A2771.
PATRICi 23329288. VBIRhoRub82919_2877.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi GFLFHAN.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci RRUB269796:GCN1-2819-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S.1.

Entry informationi

Entry nameiHISX_RHORT
AccessioniPrimary (citable) accession number: Q2RQM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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