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Q2RQM7

- HISX_RHORT

UniProt

Q2RQM7 - HISX_RHORT

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NADUniRule annotation
Binding sitei191 – 1911NADUniRule annotation
Binding sitei214 – 2141NADUniRule annotation
Binding sitei237 – 2371SubstrateUniRule annotation
Metal bindingi259 – 2591ZincUniRule annotation
Binding sitei259 – 2591SubstrateUniRule annotation
Metal bindingi262 – 2621ZincUniRule annotation
Binding sitei262 – 2621SubstrateUniRule annotation
Active sitei328 – 3281Proton acceptorUniRule annotation
Active sitei329 – 3291Proton acceptorUniRule annotation
Binding sitei329 – 3291SubstrateUniRule annotation
Metal bindingi362 – 3621ZincUniRule annotation
Binding sitei362 – 3621SubstrateUniRule annotation
Binding sitei416 – 4161SubstrateUniRule annotation
Metal bindingi421 – 4211ZincUniRule annotation
Binding sitei421 – 4211SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciRRUB269796:GCN1-2819-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Rru_A2771
OrganismiRhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Taxonomic identifieri269796 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
ProteomesiUP000001929: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Histidinol dehydrogenasePRO_0000229865Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269796.Rru_A2771.

Structurei

3D structure databases

ProteinModelPortaliQ2RQM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiGFLFHAN.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2RQM7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLRLEASSA DFAPAFAALL AGKRESAQDV NDVVSAILAD VRLRGDDALI
60 70 80 90 100
DYTARFDKMT VSAEGLRFSD DEVDTAVALI EPALRDALAL AAKRITRFHE
110 120 130 140 150
RQMPTAISFT DEDGVRLGQR WTAVSAAGLY VPGGLAAYPS SVLMNALPAK
160 170 180 190 200
VAGVERLVMV VPTPAGRINP LVLAAAKLAG VDEIYRVGGA QAVAALAYGT
210 220 230 240 250
RTIAPVDKIV GPGNAYVAAA KRQVFGTVGI DMIAGPSEIL VVADGANDPD
260 270 280 290 300
WIALDLLSQA EHDAAAQSIL ITDDRAFADR VERAVTDRLR TLSRTEIASA
310 320 330 340 350
SWRDHGAIIL VGDLLRDAPA LVDKVAPEHL ELAVADPDAL AARVRHAGAI
360 370 380 390 400
FLGRYTPEAI GDYIAGPNHV LPTSRTARFS SGLGVLDFMK RTTLVGCGAE
410 420 430
SLGAIGPSAV RLARAEGLEA HGLSVAARMN RGWE
Length:434
Mass (Da):45,648
Last modified:January 24, 2006 - v1
Checksum:iBB30BB3A879BB054
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000230 Genomic DNA. Translation: ABC23568.1.
RefSeqiWP_011390581.1. NC_007643.1.
YP_427855.1. NC_007643.1.

Genome annotation databases

EnsemblBacteriaiABC23568; ABC23568; Rru_A2771.
GeneIDi3836211.
KEGGirru:Rru_A2771.
PATRICi23329288. VBIRhoRub82919_2877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000230 Genomic DNA. Translation: ABC23568.1 .
RefSeqi WP_011390581.1. NC_007643.1.
YP_427855.1. NC_007643.1.

3D structure databases

ProteinModelPortali Q2RQM7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269796.Rru_A2771.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC23568 ; ABC23568 ; Rru_A2771 .
GeneIDi 3836211.
KEGGi rru:Rru_A2771.
PATRICi 23329288. VBIRhoRub82919_2877.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi GFLFHAN.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci RRUB269796:GCN1-2819-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S.1.

Entry informationi

Entry nameiHISX_RHORT
AccessioniPrimary (citable) accession number: Q2RQM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3