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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Rru_A3049
OrganismiRhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Taxonomic identifieri269796 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
Proteomesi
  • UP000001929 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456751 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi269796.Rru_A3049

Structurei

3D structure databases

ProteinModelPortaliQ2RPV1
SMRiQ2RPV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q2RPV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLPHSEAD RAAMLATIGA ASVEDLFRDV PREALDQAAF DALPDHGGEM
60 70 80 90 100
EVERALSALA ARNLTAGSVP CFLGAGSYRH HVPAAVDALI QRGEFLTSYT
110 120 130 140 150
PYQAEVSQGT LQYLFEFQTQ VALITGMEVA NASMYDGATA CAEAAAMAVR
160 170 180 190 200
ITRRRKVLMA GGLHPHYTAT TQTLLACLGH EGEGLPPDPL ALGDLIGRVG
210 220 230 240 250
SDTACVIVQN PDFFGRLRDL SPLAEACHAA GALLVVAVCE PVSLGLVAPP
260 270 280 290 300
GAMGADIVVA EGHALGSPTG FGGPGVGLFA TREKYLRQMP GRLAGETLDE
310 320 330 340 350
SGKRGYVLTL STREQHIRRE KATSNICTNS GLIALAFTIH MTLLGEAGFT
360 370 380 390 400
RLAWINHANA VALAEKLARV KGVKVLPETF FNEFTLRLPK PAAEVVEALA
410 420 430 440
ARSILAGVPV SRFLPTYPEL ANLLLVNATE LTTPEDADAL VAALKEVL
Length:448
Mass (Da):47,384
Last modified:January 24, 2006 - v1
Checksum:i92B0C9703B92C335
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000230 Genomic DNA Translation: ABC23844.1
RefSeqiWP_011390797.1, NC_007643.1
YP_428131.1, NC_007643.1

Genome annotation databases

EnsemblBacteriaiABC23844; ABC23844; Rru_A3049
GeneIDi3836495
KEGGirru:Rru_A3049
PATRICifig|269796.9.peg.3159

Similar proteinsi

Entry informationi

Entry nameiGCSPA_RHORT
AccessioniPrimary (citable) accession number: Q2RPV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health