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Q2RP31

- PANC_RHORT

UniProt

Q2RP31 - PANC_RHORT

Protein

Pantothenate synthetase

Gene

panC

Organism
Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei40 – 401Proton donorUniRule annotation
    Binding sitei64 – 641Beta-alanineUniRule annotation
    Binding sitei64 – 641PantoateUniRule annotation
    Binding sitei156 – 1561PantoateUniRule annotation
    Binding sitei179 – 1791ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi33 – 408ATPUniRule annotation
    Nucleotide bindingi150 – 1534ATPUniRule annotation
    Nucleotide bindingi187 – 1904ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRRUB269796:GCN1-3380-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:Rru_A3320
    OrganismiRhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
    Taxonomic identifieri269796 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
    ProteomesiUP000001929: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Pantothenate synthetasePRO_0000305537Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi269796.Rru_A3320.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2RP31.
    SMRiQ2RP31. Positions 5-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2RP31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRALPIARSV SELRAVVDGW KAEGLRVGLV PTMGALHAGH LSLVRLALSK    50
    VDRVVASVFV NPTQFGPNED FAAYPRDEAA DAAKLGGAGA HLLYAPDVAG 100
    MYPPGFSTTI TVSGVSSGLC GDLRPGHFQG VATVVAKLFL RVRPDVAVFG 150
    EKDYQQLLVL KRLVNDLDLA IEVIGAPIVR ETDGLALSSR NAYLSAEQRA 200
    LAPGLYRTLR RVGADILGGG RVDDCLAWGI DELKALGFGP VDYLDLRDGA 250
    TLERLDDAPE GPGRLLCAAY LGKTRLIDNI GV 282
    Length:282
    Mass (Da):29,896
    Last modified:October 2, 2007 - v2
    Checksum:iEEC28AB097688191
    GO

    Sequence cautioni

    The sequence ABC24114.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000230 Genomic DNA. Translation: ABC24114.1. Different initiation.
    RefSeqiYP_428401.1. NC_007643.1.

    Genome annotation databases

    EnsemblBacteriaiABC24114; ABC24114; Rru_A3320.
    GeneIDi3836772.
    KEGGirru:Rru_A3320.
    PATRICi23330426. VBIRhoRub82919_3433.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000230 Genomic DNA. Translation: ABC24114.1 . Different initiation.
    RefSeqi YP_428401.1. NC_007643.1.

    3D structure databases

    ProteinModelPortali Q2RP31.
    SMRi Q2RP31. Positions 5-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269796.Rru_A3320.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC24114 ; ABC24114 ; Rru_A3320 .
    GeneIDi 3836772.
    KEGGi rru:Rru_A3320.
    PATRICi 23330426. VBIRhoRub82919_3433.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci RRUB269796:GCN1-3380-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
      , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C.
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S.1.

    Entry informationi

    Entry nameiPANC_RHORT
    AccessioniPrimary (citable) accession number: Q2RP31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3