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Q2RN70

- SYL_RHORT

UniProt

Q2RN70 - SYL_RHORT

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRRUB269796:GCN1-3695-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Rru_A3631
OrganismiRhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Taxonomic identifieri269796 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
ProteomesiUP000001929: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Leucine--tRNA ligasePRO_0000334805Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269796.Rru_A3631.

Structurei

3D structure databases

ProteinModelPortaliQ2RN70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5411"HIGH" regionAdd
BLAST
Motifi622 – 6265"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2RN70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASEDRYNVK ETEAKWQTAW AEGGCFTARE DRTRPKYYVL EMFPYPSGRI
60 70 80 90 100
HMGHVRNYTL GDVVARFKRA QGFNVLHPMG WDAFGLPAEN AAIQRGVHPA
110 120 130 140 150
TWTRQNIAIM REQFKPMGLS IDWSREVSTC EPAYYRHEQK MFLDFLKAGL
160 170 180 190 200
AYRRESWVNW DPVEHTVLAN EQVIDGKGWR SGAPVERRKL SQWFLRITRY
210 220 230 240 250
AEDLLAAIGD LDRWPDKVRL MQTNWIGRSE GARVRFGLVG RDQALEVYTT
260 270 280 290 300
RPDTLFGASF CAISANHPLA AEIAATNPDL AAFIAECGRM GTSEVEIETA
310 320 330 340 350
EKKGFDTGLK VRHPFDPAWE LPVYVANFVL MEYGTGAIFG CPAHDQRDMD
360 370 380 390 400
FARKYGLPVR AVVAPAGVDA EAFAKDLEAS DTAFSEDGVA IASGFLDGLP
410 420 430 440 450
VSEAKARAIA HIAELGAGEG VVQFRLRDWG VSRQRYWGCP IPIIHCDDCG
460 470 480 490 500
PVPVPEDQLP VLLPEDVTFD KPGNPLDHHP TWKHVACPQC GKPARRETDT
510 520 530 540 550
FDTFFESSWY FARFCAPHDT DRAFEREAVD YWLPVDQYVG GVEHAVLHLL
560 570 580 590 600
YSRFFTRALR DCGYLGVSEP FTGLFTQGMI CHETYRDTDG AWLSPDQIDK
610 620 630 640 650
AADGTATLLS DGSPVSVGRS EKMSKSKMNT VDPTAILESY GADAARLFML
660 670 680 690 700
SDSPPDRDMD WTDSGIEGAW RYIGRLWRMA LQPQIDPGAV GAPLPADLGP
710 720 730 740 750
GAAALVRHVH KAVAGVTDDL EKFRFNAAVA RLRELTNAIA ALDGKEAGAG
760 770 780 790 800
AVYRFALETA ARLAAPMIPH IAEEMWSHLG RDGLLAETPW PTWDPLMLID
810 820 830 840 850
DQVTIAVQVN GKMRGTVDLP KDAKREDAEA AALALPTVLA QLAGAAPRKV
860
IVVPNRIINV VV
Length:862
Mass (Da):95,530
Last modified:January 24, 2006 - v1
Checksum:i9D92FEB9305F579A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000230 Genomic DNA. Translation: ABC24425.1.
RefSeqiWP_011391378.1. NC_007643.1.
YP_428712.1. NC_007643.1.

Genome annotation databases

EnsemblBacteriaiABC24425; ABC24425; Rru_A3631.
GeneIDi3837087.
KEGGirru:Rru_A3631.
PATRICi23331070. VBIRhoRub82919_3752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000230 Genomic DNA. Translation: ABC24425.1 .
RefSeqi WP_011391378.1. NC_007643.1.
YP_428712.1. NC_007643.1.

3D structure databases

ProteinModelPortali Q2RN70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269796.Rru_A3631.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC24425 ; ABC24425 ; Rru_A3631 .
GeneIDi 3837087.
KEGGi rru:Rru_A3631.
PATRICi 23331070. VBIRhoRub82919_3752.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RRUB269796:GCN1-3695-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S.1.

Entry informationi

Entry nameiSYL_RHORT
AccessioniPrimary (citable) accession number: Q2RN70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 24, 2006
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3