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Q2RN70

- SYL_RHORT

UniProt

Q2RN70 - SYL_RHORT

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei625 – 6251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRRUB269796:GCN1-3695-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Rru_A3631
    OrganismiRhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
    Taxonomic identifieri269796 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
    ProteomesiUP000001929: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 862862Leucine--tRNA ligasePRO_0000334805Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269796.Rru_A3631.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2RN70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 5411"HIGH" regionAdd
    BLAST
    Motifi622 – 6265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2RN70-1 [UniParc]FASTAAdd to Basket

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    MASEDRYNVK ETEAKWQTAW AEGGCFTARE DRTRPKYYVL EMFPYPSGRI    50
    HMGHVRNYTL GDVVARFKRA QGFNVLHPMG WDAFGLPAEN AAIQRGVHPA 100
    TWTRQNIAIM REQFKPMGLS IDWSREVSTC EPAYYRHEQK MFLDFLKAGL 150
    AYRRESWVNW DPVEHTVLAN EQVIDGKGWR SGAPVERRKL SQWFLRITRY 200
    AEDLLAAIGD LDRWPDKVRL MQTNWIGRSE GARVRFGLVG RDQALEVYTT 250
    RPDTLFGASF CAISANHPLA AEIAATNPDL AAFIAECGRM GTSEVEIETA 300
    EKKGFDTGLK VRHPFDPAWE LPVYVANFVL MEYGTGAIFG CPAHDQRDMD 350
    FARKYGLPVR AVVAPAGVDA EAFAKDLEAS DTAFSEDGVA IASGFLDGLP 400
    VSEAKARAIA HIAELGAGEG VVQFRLRDWG VSRQRYWGCP IPIIHCDDCG 450
    PVPVPEDQLP VLLPEDVTFD KPGNPLDHHP TWKHVACPQC GKPARRETDT 500
    FDTFFESSWY FARFCAPHDT DRAFEREAVD YWLPVDQYVG GVEHAVLHLL 550
    YSRFFTRALR DCGYLGVSEP FTGLFTQGMI CHETYRDTDG AWLSPDQIDK 600
    AADGTATLLS DGSPVSVGRS EKMSKSKMNT VDPTAILESY GADAARLFML 650
    SDSPPDRDMD WTDSGIEGAW RYIGRLWRMA LQPQIDPGAV GAPLPADLGP 700
    GAAALVRHVH KAVAGVTDDL EKFRFNAAVA RLRELTNAIA ALDGKEAGAG 750
    AVYRFALETA ARLAAPMIPH IAEEMWSHLG RDGLLAETPW PTWDPLMLID 800
    DQVTIAVQVN GKMRGTVDLP KDAKREDAEA AALALPTVLA QLAGAAPRKV 850
    IVVPNRIINV VV 862
    Length:862
    Mass (Da):95,530
    Last modified:January 24, 2006 - v1
    Checksum:i9D92FEB9305F579A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000230 Genomic DNA. Translation: ABC24425.1.
    RefSeqiYP_428712.1. NC_007643.1.

    Genome annotation databases

    EnsemblBacteriaiABC24425; ABC24425; Rru_A3631.
    GeneIDi3837087.
    KEGGirru:Rru_A3631.
    PATRICi23331070. VBIRhoRub82919_3752.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000230 Genomic DNA. Translation: ABC24425.1 .
    RefSeqi YP_428712.1. NC_007643.1.

    3D structure databases

    ProteinModelPortali Q2RN70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269796.Rru_A3631.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC24425 ; ABC24425 ; Rru_A3631 .
    GeneIDi 3837087.
    KEGGi rru:Rru_A3631.
    PATRICi 23331070. VBIRhoRub82919_3752.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RRUB269796:GCN1-3695-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
      , Kyrpides N., Mavrommatis K., Richardson P., Zhang Y., Roberts G., Reslewic S., Zhou S., Schwartz D.C.
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S.1.

    Entry informationi

    Entry nameiSYL_RHORT
    AccessioniPrimary (citable) accession number: Q2RN70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3