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Q2RM91

- FTHS_MOOTA

UniProt

Q2RM91 - FTHS_MOOTA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMTHE264732:GH0A-119-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Moth_0109
    OrganismiMoorella thermoacetica (strain ATCC 39073)
    Taxonomic identifieri264732 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
    ProteomesiUP000007053: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000300530Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264732.Moth_0109.

    Structurei

    Secondary structure

    1
    559
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 126
    Helixi19 – 257
    Helixi30 – 323
    Beta strandi33 – 397
    Beta strandi41 – 433
    Helixi45 – 506
    Turni51 – 533
    Beta strandi58 – 658
    Helixi74 – 8714
    Beta strandi92 – 965
    Helixi102 – 1054
    Turni106 – 1083
    Beta strandi112 – 1143
    Beta strandi117 – 1204
    Helixi122 – 1265
    Turni127 – 1304
    Helixi132 – 15221
    Helixi161 – 1633
    Beta strandi168 – 1725
    Helixi175 – 1773
    Beta strandi178 – 1825
    Helixi187 – 1893
    Beta strandi193 – 1953
    Beta strandi197 – 1993
    Helixi200 – 2023
    Helixi204 – 2118
    Helixi215 – 22410
    Beta strandi226 – 2305
    Beta strandi235 – 2373
    Helixi239 – 2413
    Helixi244 – 2507
    Turni251 – 2555
    Beta strandi258 – 2625
    Beta strandi267 – 2704
    Beta strandi276 – 2794
    Helixi285 – 29410
    Beta strandi296 – 30510
    Turni306 – 3083
    Helixi309 – 3157
    Helixi317 – 3215
    Beta strandi327 – 3326
    Helixi334 – 3407
    Helixi345 – 3473
    Helixi353 – 37119
    Turni372 – 3743
    Beta strandi377 – 3826
    Helixi389 – 40113
    Beta strandi405 – 4095
    Helixi411 – 4144
    Helixi415 – 4195
    Helixi420 – 43213
    Helixi447 – 45711
    Beta strandi464 – 4663
    Helixi468 – 47912
    Beta strandi496 – 4983
    Beta strandi511 – 5133
    Beta strandi515 – 5195
    Turni520 – 5234
    Beta strandi524 – 5285
    Helixi543 – 5464
    Beta strandi555 – 5573

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IOJX-ray2.20A/B1-559[»]
    4IOKX-ray2.50A/B1-559[»]
    4IOLX-ray2.56A/B1-559[»]
    4IOMX-ray3.00A/B1-559[»]
    ProteinModelPortaliQ2RM91.
    SMRiQ2RM91. Positions 7-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiTWRRCLD.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2RM91-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKVPSDIEI AQAAKMKPVM ELARGLGIQE DEVELYGKYK AKISLDVYRR    50
    LKDKPDGKLI LVTAITPTPA GEGKTTTSVG LTDALARLGK RVMVCLREPS 100
    LGPSFGIKGG AAGGGYAQVV PMEDINLHFT GDIHAVTYAH NLLAAMVDNH 150
    LQQGNVLNID PRTITWRRVI DLNDRALRNI VIGLGGKANG VPRETGFDIS 200
    VASEVMACLC LASDLMDLKE RFSRIVVGYT YDGKPVTAGD LEAQGSMALL 250
    MKDAIKPNLV QTLENTPAFI HGGPFANIAH GCNSIIATKT ALKLADYVVT 300
    EAGFGADLGA EKFYDVKCRY AGFKPDATVI VATVRALKMH GGVPKSDLAT 350
    ENLEALREGF ANLEKHIENI GKFGVPAVVA INAFPTDTEA ELNLLYELCA 400
    KAGAEVALSE VWAKGGEGGL ELARKVLQTL ESRPSNFHVL YNLDLSIKDK 450
    IAKIATEIYG ADGVNYTAEA DKAIQRYESL GYGNLPVVMA KTQYSFSDDM 500
    TKLGRPRNFT ITVREVRLSA GAGFIVPITG AIMTMPGLPK RPAACNIDID 550
    ADGVITGLF 559
    Length:559
    Mass (Da):59,942
    Last modified:January 24, 2006 - v1
    Checksum:iD8CD2BB52FC35A4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000232 Genomic DNA. Translation: ABC18448.1.
    RefSeqiYP_428991.1. NC_007644.1.

    Genome annotation databases

    EnsemblBacteriaiABC18448; ABC18448; Moth_0109.
    GeneIDi3831999.
    KEGGimta:Moth_0109.
    PATRICi22637215. VBIMooThe6753_0114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000232 Genomic DNA. Translation: ABC18448.1 .
    RefSeqi YP_428991.1. NC_007644.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IOJ X-ray 2.20 A/B 1-559 [» ]
    4IOK X-ray 2.50 A/B 1-559 [» ]
    4IOL X-ray 2.56 A/B 1-559 [» ]
    4IOM X-ray 3.00 A/B 1-559 [» ]
    ProteinModelPortali Q2RM91.
    SMRi Q2RM91. Positions 7-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264732.Moth_0109.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC18448 ; ABC18448 ; Moth_0109 .
    GeneIDi 3831999.
    KEGGi mta:Moth_0109.
    PATRICi 22637215. VBIMooThe6753_0114.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi TWRRCLD.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci MTHE264732:GH0A-119-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39073.

    Entry informationi

    Entry nameiFTHS_MOOTA
    AccessioniPrimary (citable) accession number: Q2RM91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3