Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2RM91

- FTHS_MOOTA

UniProt

Q2RM91 - FTHS_MOOTA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE264732:GH0A-119-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Moth_0109
OrganismiMoorella thermoacetica (strain ATCC 39073)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
ProteomesiUP000007053: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000300530Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_0109.

Structurei

Secondary structure

1
559
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 126Combined sources
Helixi19 – 257Combined sources
Helixi30 – 323Combined sources
Beta strandi33 – 397Combined sources
Beta strandi41 – 433Combined sources
Helixi45 – 506Combined sources
Turni51 – 533Combined sources
Beta strandi58 – 658Combined sources
Helixi74 – 8714Combined sources
Beta strandi92 – 965Combined sources
Helixi102 – 1054Combined sources
Turni106 – 1083Combined sources
Beta strandi112 – 1143Combined sources
Beta strandi117 – 1204Combined sources
Helixi122 – 1265Combined sources
Turni127 – 1304Combined sources
Helixi132 – 15221Combined sources
Helixi161 – 1633Combined sources
Beta strandi168 – 1725Combined sources
Helixi175 – 1773Combined sources
Beta strandi178 – 1825Combined sources
Helixi187 – 1893Combined sources
Beta strandi193 – 1953Combined sources
Beta strandi197 – 1993Combined sources
Helixi200 – 2023Combined sources
Helixi204 – 2118Combined sources
Helixi215 – 22410Combined sources
Beta strandi226 – 2305Combined sources
Beta strandi235 – 2373Combined sources
Helixi239 – 2413Combined sources
Helixi244 – 2507Combined sources
Turni251 – 2555Combined sources
Beta strandi258 – 2625Combined sources
Beta strandi267 – 2704Combined sources
Beta strandi276 – 2794Combined sources
Helixi285 – 29410Combined sources
Beta strandi296 – 30510Combined sources
Turni306 – 3083Combined sources
Helixi309 – 3157Combined sources
Helixi317 – 3215Combined sources
Beta strandi327 – 3326Combined sources
Helixi334 – 3407Combined sources
Helixi345 – 3473Combined sources
Helixi353 – 37119Combined sources
Turni372 – 3743Combined sources
Beta strandi377 – 3826Combined sources
Helixi389 – 40113Combined sources
Beta strandi405 – 4095Combined sources
Helixi411 – 4144Combined sources
Helixi415 – 4195Combined sources
Helixi420 – 43213Combined sources
Helixi447 – 45711Combined sources
Beta strandi464 – 4663Combined sources
Helixi468 – 47912Combined sources
Beta strandi496 – 4983Combined sources
Beta strandi511 – 5133Combined sources
Beta strandi515 – 5195Combined sources
Turni520 – 5234Combined sources
Beta strandi524 – 5285Combined sources
Helixi543 – 5464Combined sources
Beta strandi555 – 5573Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IOJX-ray2.20A/B1-559[»]
4IOKX-ray2.50A/B1-559[»]
4IOLX-ray2.56A/B1-559[»]
4IOMX-ray3.00A/B1-559[»]
ProteinModelPortaliQ2RM91.
SMRiQ2RM91. Positions 7-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiTWRRCLD.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2RM91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKVPSDIEI AQAAKMKPVM ELARGLGIQE DEVELYGKYK AKISLDVYRR
60 70 80 90 100
LKDKPDGKLI LVTAITPTPA GEGKTTTSVG LTDALARLGK RVMVCLREPS
110 120 130 140 150
LGPSFGIKGG AAGGGYAQVV PMEDINLHFT GDIHAVTYAH NLLAAMVDNH
160 170 180 190 200
LQQGNVLNID PRTITWRRVI DLNDRALRNI VIGLGGKANG VPRETGFDIS
210 220 230 240 250
VASEVMACLC LASDLMDLKE RFSRIVVGYT YDGKPVTAGD LEAQGSMALL
260 270 280 290 300
MKDAIKPNLV QTLENTPAFI HGGPFANIAH GCNSIIATKT ALKLADYVVT
310 320 330 340 350
EAGFGADLGA EKFYDVKCRY AGFKPDATVI VATVRALKMH GGVPKSDLAT
360 370 380 390 400
ENLEALREGF ANLEKHIENI GKFGVPAVVA INAFPTDTEA ELNLLYELCA
410 420 430 440 450
KAGAEVALSE VWAKGGEGGL ELARKVLQTL ESRPSNFHVL YNLDLSIKDK
460 470 480 490 500
IAKIATEIYG ADGVNYTAEA DKAIQRYESL GYGNLPVVMA KTQYSFSDDM
510 520 530 540 550
TKLGRPRNFT ITVREVRLSA GAGFIVPITG AIMTMPGLPK RPAACNIDID

ADGVITGLF
Length:559
Mass (Da):59,942
Last modified:January 24, 2006 - v1
Checksum:iD8CD2BB52FC35A4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC18448.1.
RefSeqiWP_011391657.1. NC_007644.1.
YP_428991.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC18448; ABC18448; Moth_0109.
GeneIDi3831999.
KEGGimta:Moth_0109.
PATRICi22637215. VBIMooThe6753_0114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC18448.1 .
RefSeqi WP_011391657.1. NC_007644.1.
YP_428991.1. NC_007644.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IOJ X-ray 2.20 A/B 1-559 [» ]
4IOK X-ray 2.50 A/B 1-559 [» ]
4IOL X-ray 2.56 A/B 1-559 [» ]
4IOM X-ray 3.00 A/B 1-559 [» ]
ProteinModelPortali Q2RM91.
SMRi Q2RM91. Positions 7-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264732.Moth_0109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC18448 ; ABC18448 ; Moth_0109 .
GeneIDi 3831999.
KEGGi mta:Moth_0109.
PATRICi 22637215. VBIMooThe6753_0114.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi TWRRCLD.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MTHE264732:GH0A-119-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39073.

Entry informationi

Entry nameiFTHS_MOOTA
AccessioniPrimary (citable) accession number: Q2RM91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 24, 2006
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3