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Q2RM91

- FTHS_MOOTA

UniProt

Q2RM91 - FTHS_MOOTA

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE264732:GH0A-119-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Moth_0109
OrganismiMoorella thermoacetica (strain ATCC 39073)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
ProteomesiUP000007053: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000300530Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_0109.

Structurei

Secondary structure

1
559
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 126
Helixi19 – 257
Helixi30 – 323
Beta strandi33 – 397
Beta strandi41 – 433
Helixi45 – 506
Turni51 – 533
Beta strandi58 – 658
Helixi74 – 8714
Beta strandi92 – 965
Helixi102 – 1054
Turni106 – 1083
Beta strandi112 – 1143
Beta strandi117 – 1204
Helixi122 – 1265
Turni127 – 1304
Helixi132 – 15221
Helixi161 – 1633
Beta strandi168 – 1725
Helixi175 – 1773
Beta strandi178 – 1825
Helixi187 – 1893
Beta strandi193 – 1953
Beta strandi197 – 1993
Helixi200 – 2023
Helixi204 – 2118
Helixi215 – 22410
Beta strandi226 – 2305
Beta strandi235 – 2373
Helixi239 – 2413
Helixi244 – 2507
Turni251 – 2555
Beta strandi258 – 2625
Beta strandi267 – 2704
Beta strandi276 – 2794
Helixi285 – 29410
Beta strandi296 – 30510
Turni306 – 3083
Helixi309 – 3157
Helixi317 – 3215
Beta strandi327 – 3326
Helixi334 – 3407
Helixi345 – 3473
Helixi353 – 37119
Turni372 – 3743
Beta strandi377 – 3826
Helixi389 – 40113
Beta strandi405 – 4095
Helixi411 – 4144
Helixi415 – 4195
Helixi420 – 43213
Helixi447 – 45711
Beta strandi464 – 4663
Helixi468 – 47912
Beta strandi496 – 4983
Beta strandi511 – 5133
Beta strandi515 – 5195
Turni520 – 5234
Beta strandi524 – 5285
Helixi543 – 5464
Beta strandi555 – 5573

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IOJX-ray2.20A/B1-559[»]
4IOKX-ray2.50A/B1-559[»]
4IOLX-ray2.56A/B1-559[»]
4IOMX-ray3.00A/B1-559[»]
ProteinModelPortaliQ2RM91.
SMRiQ2RM91. Positions 7-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiTWRRCLD.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2RM91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKVPSDIEI AQAAKMKPVM ELARGLGIQE DEVELYGKYK AKISLDVYRR
60 70 80 90 100
LKDKPDGKLI LVTAITPTPA GEGKTTTSVG LTDALARLGK RVMVCLREPS
110 120 130 140 150
LGPSFGIKGG AAGGGYAQVV PMEDINLHFT GDIHAVTYAH NLLAAMVDNH
160 170 180 190 200
LQQGNVLNID PRTITWRRVI DLNDRALRNI VIGLGGKANG VPRETGFDIS
210 220 230 240 250
VASEVMACLC LASDLMDLKE RFSRIVVGYT YDGKPVTAGD LEAQGSMALL
260 270 280 290 300
MKDAIKPNLV QTLENTPAFI HGGPFANIAH GCNSIIATKT ALKLADYVVT
310 320 330 340 350
EAGFGADLGA EKFYDVKCRY AGFKPDATVI VATVRALKMH GGVPKSDLAT
360 370 380 390 400
ENLEALREGF ANLEKHIENI GKFGVPAVVA INAFPTDTEA ELNLLYELCA
410 420 430 440 450
KAGAEVALSE VWAKGGEGGL ELARKVLQTL ESRPSNFHVL YNLDLSIKDK
460 470 480 490 500
IAKIATEIYG ADGVNYTAEA DKAIQRYESL GYGNLPVVMA KTQYSFSDDM
510 520 530 540 550
TKLGRPRNFT ITVREVRLSA GAGFIVPITG AIMTMPGLPK RPAACNIDID

ADGVITGLF
Length:559
Mass (Da):59,942
Last modified:January 24, 2006 - v1
Checksum:iD8CD2BB52FC35A4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000232 Genomic DNA. Translation: ABC18448.1.
RefSeqiWP_011391657.1. NC_007644.1.
YP_428991.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC18448; ABC18448; Moth_0109.
GeneIDi3831999.
KEGGimta:Moth_0109.
PATRICi22637215. VBIMooThe6753_0114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000232 Genomic DNA. Translation: ABC18448.1 .
RefSeqi WP_011391657.1. NC_007644.1.
YP_428991.1. NC_007644.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IOJ X-ray 2.20 A/B 1-559 [» ]
4IOK X-ray 2.50 A/B 1-559 [» ]
4IOL X-ray 2.56 A/B 1-559 [» ]
4IOM X-ray 3.00 A/B 1-559 [» ]
ProteinModelPortali Q2RM91.
SMRi Q2RM91. Positions 7-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264732.Moth_0109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC18448 ; ABC18448 ; Moth_0109 .
GeneIDi 3831999.
KEGGi mta:Moth_0109.
PATRICi 22637215. VBIMooThe6753_0114.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi TWRRCLD.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MTHE264732:GH0A-119-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39073.

Entry informationi

Entry nameiFTHS_MOOTA
AccessioniPrimary (citable) accession number: Q2RM91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3