Q2RLC8 (UXUA_MOOTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	Moth_0430

Organism

Moorella thermoacetica (strain ATCC 39073)

Taxonomic identifier

264732 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Moorella group › Moorella

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Mannonate dehydratase HAMAP MF_00106		PRO_1000034334

Sequences

	Sequence		Length	Mass (Da)
	Q2RLC8 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: F25F62ECDC20C490	FASTA	359	40,902
	10 20 30 40 50 60 MKMTFRWFGE GYDSISLDKI RQIPGKPGIV SAIYDVPVGE VWPEEKIKKL KETVENAGLE 70 80 90 100 110 120 LEVIESVNVH EDIKLGLPSR DRYIENYQQT LRNLAKFGIK VVCYNFMPIF DWTRSDLAKV 130 140 150 160 170 180 LPDGSTALSY EEEKVQKVDP NRMVEEVEAN SNGFELPGWE PERLKTLKVL FEQYKSVDEE 190 200 210 220 230 240 KLLKNLGYFL RAIIPVAEEV DIKMAIHPDD PPWSIFGLPR IVKSKESLEK IMALVDSPYN 250 260 270 280 290 300 GITLCSGSLG ANPDNDIPAL IRYFGAKGRI HFGHVRNIKI HSLRNFDESS HLSSDGSLDM 310 320 330 340 350 FEIMKAYHDI DFKGYIRPDH GRMIWGEVGR PGYGLYDRAL GIAYLNGLWE AIGKMKKVC

References

[1]

"The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)." Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C., Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W. Environ. Microbiol. 10:2550-2573(2008) [PubMed: 18631365] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39073.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000232 Genomic DNA. Translation: ABC18761.1.
RefSeq	YP_429304.1. NC_007644.1.
3D structure databases
ProteinModelPortal	Q2RLC8.
SMR	Q2RLC8. Positions 1-354.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2RLC8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3830954.
GenomeReviews	Gene locus Moth_0430 in contig CP000232_GR.
KEGG	mta:Moth_0430.
NMPDR	fig|264732.9.peg.408.
PATRIC	22637933. VBIMooThe6753_0464.
Phylogenomic databases
eggNOG	COG1312.
HOGENOM	HBG585927.
OMA	DIKLGKP.
PhylomeDB	Q2RLC8.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	MTHE264732:MOTH_0430-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 2 hits.
ProtoNet	Search...

Entry information

Entry name

UXUA_MOOTA

Accession

Primary (citable) accession number: Q2RLC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program