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Q2RKZ1

- SYL_MOOTA

UniProt

Q2RKZ1 - SYL_MOOTA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei585 – 5851ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE264732:GH0A-600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Moth_0568
OrganismiMoorella thermoacetica (strain ATCC 39073)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
ProteomesiUP000007053: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Leucine--tRNA ligasePRO_0000334772Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_0568.

Structurei

3D structure databases

ProteinModelPortaliQ2RKZ1.
SMRiQ2RKZ1. Positions 4-761.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi582 – 5865"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2RKZ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEARYNFKEI EPKWQRRWEA SDLYRVTEDP DKPKFYCLEM FPYPSGNLHM
60 70 80 90 100
GHVRNYSIGD VVARVKRMRG YNVLHPMGWD AFGLPAENAA IHRGIPPAEW
110 120 130 140 150
TWSNIANMRR QLHAMGISYD WDREVATCHP NYYRWTQWLF LQMYKHGLAY
160 170 180 190 200
RKKAAVNWCP SCATVLANEQ VVDGACERCH TPVMRKDLEQ WFFRITDYAD
210 220 230 240 250
RLLEDLKKLP GWPDKVKIMQ ENWIGKSSGA EVVFRVEGSG EEIPVFTTRP
260 270 280 290 300
DTLYGVTYLV LAPEHPLVEK LTAGTPYEGP VEEFVQAARY LSALDRTATE
310 320 330 340 350
KEKEGLFTGA YAINPVNNER VPIWIANYVL MEYGTGAVMG VPAHDQRDFE
360 370 380 390 400
FARKYDLPVK VVIRPASSEL PAGELAAAYV EDGIMVNSGP FNGLPNREGI
410 420 430 440 450
QKVTEYLESI GRGRARVNYR LRDWLISRQR YWGAPIPMIY CDQCGIVPVP
460 470 480 490 500
EEDLPVILPE GVEFRPTGES PLTYCPEFVN TTCPRCGGPA RRETDTMDTF
510 520 530 540 550
VCSSWYFLRY TSPHSQDRAF ERDKVDYWMN VDQYIGGVEH AILHLMYARF
560 570 580 590 600
FTKALHDFGL VGVEEPFQNL LTQGMVLKDG SKMSKSKGNI VSPEEIINRY
610 620 630 640 650
GADTARLFIL FAAPPERDLE WSDQGVEGCY RFLNRVWRLV GSYADAVRRA
660 670 680 690 700
GGSLEIRSHA DRELWRLLHA TIKKVTEDVE ERFNFNTAIS AIMELVNGCY
710 720 730 740 750
RYQDTVPEEE QNLVLMGEVL RKLVTLLAPF APHITEELWQ GLGGQESVHR
760 770 780 790 800
ESWPQYDPEA LVEEEITLVI QINGKVKDRM QVPAGLAREK IEELVLNRDK
810 820
VAALLAGQQV VKVIVVPDKL VNVVARRAS
Length:829
Mass (Da):94,798
Last modified:January 24, 2006 - v1
Checksum:i61B06E2164BF6103
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000232 Genomic DNA. Translation: ABC18898.1.
RefSeqiYP_429441.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC18898; ABC18898; Moth_0568.
GeneIDi3832481.
KEGGimta:Moth_0568.
PATRICi22638241. VBIMooThe6753_0611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000232 Genomic DNA. Translation: ABC18898.1 .
RefSeqi YP_429441.1. NC_007644.1.

3D structure databases

ProteinModelPortali Q2RKZ1.
SMRi Q2RKZ1. Positions 4-761.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264732.Moth_0568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC18898 ; ABC18898 ; Moth_0568 .
GeneIDi 3832481.
KEGGi mta:Moth_0568.
PATRICi 22638241. VBIMooThe6753_0611.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MTHE264732:GH0A-600-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39073.

Entry informationi

Entry nameiSYL_MOOTA
AccessioniPrimary (citable) accession number: Q2RKZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3