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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei585ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE264732:G1G5J-600-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Moth_0568
OrganismiMoorella thermoacetica (strain ATCC 39073 / JCM 9320)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
Proteomesi
  • UP000007053 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347721 – 829Leucine--tRNA ligaseAdd BLAST829

Proteomic databases

PRIDEiQ2RKZ1

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_0568

Structurei

3D structure databases

ProteinModelPortaliQ2RKZ1
SMRiQ2RKZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi582 – 586"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q2RKZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARYNFKEI EPKWQRRWEA SDLYRVTEDP DKPKFYCLEM FPYPSGNLHM
60 70 80 90 100
GHVRNYSIGD VVARVKRMRG YNVLHPMGWD AFGLPAENAA IHRGIPPAEW
110 120 130 140 150
TWSNIANMRR QLHAMGISYD WDREVATCHP NYYRWTQWLF LQMYKHGLAY
160 170 180 190 200
RKKAAVNWCP SCATVLANEQ VVDGACERCH TPVMRKDLEQ WFFRITDYAD
210 220 230 240 250
RLLEDLKKLP GWPDKVKIMQ ENWIGKSSGA EVVFRVEGSG EEIPVFTTRP
260 270 280 290 300
DTLYGVTYLV LAPEHPLVEK LTAGTPYEGP VEEFVQAARY LSALDRTATE
310 320 330 340 350
KEKEGLFTGA YAINPVNNER VPIWIANYVL MEYGTGAVMG VPAHDQRDFE
360 370 380 390 400
FARKYDLPVK VVIRPASSEL PAGELAAAYV EDGIMVNSGP FNGLPNREGI
410 420 430 440 450
QKVTEYLESI GRGRARVNYR LRDWLISRQR YWGAPIPMIY CDQCGIVPVP
460 470 480 490 500
EEDLPVILPE GVEFRPTGES PLTYCPEFVN TTCPRCGGPA RRETDTMDTF
510 520 530 540 550
VCSSWYFLRY TSPHSQDRAF ERDKVDYWMN VDQYIGGVEH AILHLMYARF
560 570 580 590 600
FTKALHDFGL VGVEEPFQNL LTQGMVLKDG SKMSKSKGNI VSPEEIINRY
610 620 630 640 650
GADTARLFIL FAAPPERDLE WSDQGVEGCY RFLNRVWRLV GSYADAVRRA
660 670 680 690 700
GGSLEIRSHA DRELWRLLHA TIKKVTEDVE ERFNFNTAIS AIMELVNGCY
710 720 730 740 750
RYQDTVPEEE QNLVLMGEVL RKLVTLLAPF APHITEELWQ GLGGQESVHR
760 770 780 790 800
ESWPQYDPEA LVEEEITLVI QINGKVKDRM QVPAGLAREK IEELVLNRDK
810 820
VAALLAGQQV VKVIVVPDKL VNVVARRAS
Length:829
Mass (Da):94,798
Last modified:January 24, 2006 - v1
Checksum:i61B06E2164BF6103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA Translation: ABC18898.1
RefSeqiWP_011392105.1, NC_007644.1
YP_429441.1, NC_007644.1

Genome annotation databases

EnsemblBacteriaiABC18898; ABC18898; Moth_0568
GeneIDi3832481
KEGGimta:Moth_0568
PATRICifig|264732.11.peg.611

Similar proteinsi

Entry informationi

Entry nameiSYL_MOOTA
AccessioniPrimary (citable) accession number: Q2RKZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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