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Q2RKZ1

- SYL_MOOTA

UniProt

Q2RKZ1 - SYL_MOOTA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei585 – 5851ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMTHE264732:GH0A-600-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Moth_0568
    OrganismiMoorella thermoacetica (strain ATCC 39073)
    Taxonomic identifieri264732 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
    ProteomesiUP000007053: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 829829Leucine--tRNA ligasePRO_0000334772Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264732.Moth_0568.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2RKZ1.
    SMRiQ2RKZ1. Positions 4-761.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi582 – 5865"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2RKZ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEARYNFKEI EPKWQRRWEA SDLYRVTEDP DKPKFYCLEM FPYPSGNLHM    50
    GHVRNYSIGD VVARVKRMRG YNVLHPMGWD AFGLPAENAA IHRGIPPAEW 100
    TWSNIANMRR QLHAMGISYD WDREVATCHP NYYRWTQWLF LQMYKHGLAY 150
    RKKAAVNWCP SCATVLANEQ VVDGACERCH TPVMRKDLEQ WFFRITDYAD 200
    RLLEDLKKLP GWPDKVKIMQ ENWIGKSSGA EVVFRVEGSG EEIPVFTTRP 250
    DTLYGVTYLV LAPEHPLVEK LTAGTPYEGP VEEFVQAARY LSALDRTATE 300
    KEKEGLFTGA YAINPVNNER VPIWIANYVL MEYGTGAVMG VPAHDQRDFE 350
    FARKYDLPVK VVIRPASSEL PAGELAAAYV EDGIMVNSGP FNGLPNREGI 400
    QKVTEYLESI GRGRARVNYR LRDWLISRQR YWGAPIPMIY CDQCGIVPVP 450
    EEDLPVILPE GVEFRPTGES PLTYCPEFVN TTCPRCGGPA RRETDTMDTF 500
    VCSSWYFLRY TSPHSQDRAF ERDKVDYWMN VDQYIGGVEH AILHLMYARF 550
    FTKALHDFGL VGVEEPFQNL LTQGMVLKDG SKMSKSKGNI VSPEEIINRY 600
    GADTARLFIL FAAPPERDLE WSDQGVEGCY RFLNRVWRLV GSYADAVRRA 650
    GGSLEIRSHA DRELWRLLHA TIKKVTEDVE ERFNFNTAIS AIMELVNGCY 700
    RYQDTVPEEE QNLVLMGEVL RKLVTLLAPF APHITEELWQ GLGGQESVHR 750
    ESWPQYDPEA LVEEEITLVI QINGKVKDRM QVPAGLAREK IEELVLNRDK 800
    VAALLAGQQV VKVIVVPDKL VNVVARRAS 829
    Length:829
    Mass (Da):94,798
    Last modified:January 24, 2006 - v1
    Checksum:i61B06E2164BF6103
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000232 Genomic DNA. Translation: ABC18898.1.
    RefSeqiYP_429441.1. NC_007644.1.

    Genome annotation databases

    EnsemblBacteriaiABC18898; ABC18898; Moth_0568.
    GeneIDi3832481.
    KEGGimta:Moth_0568.
    PATRICi22638241. VBIMooThe6753_0611.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000232 Genomic DNA. Translation: ABC18898.1 .
    RefSeqi YP_429441.1. NC_007644.1.

    3D structure databases

    ProteinModelPortali Q2RKZ1.
    SMRi Q2RKZ1. Positions 4-761.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264732.Moth_0568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC18898 ; ABC18898 ; Moth_0568 .
    GeneIDi 3832481.
    KEGGi mta:Moth_0568.
    PATRICi 22638241. VBIMooThe6753_0611.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MTHE264732:GH0A-600-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39073.

    Entry informationi

    Entry nameiSYL_MOOTA
    AccessioniPrimary (citable) accession number: Q2RKZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3