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Q2RKY8

- UPPP_MOOTA

UniProt

Q2RKY8 - UPPP_MOOTA

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciMTHE264732:GH0A-603-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Moth_0571
    OrganismiMoorella thermoacetica (strain ATCC 39073)
    Taxonomic identifieri264732 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
    ProteomesiUP000007053: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Undecaprenyl-diphosphatasePRO_0000250245Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264732.Moth_0571.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei79 – 9921HelicalUniRule annotationAdd
    BLAST
    Transmembranei106 – 12621HelicalUniRule annotationAdd
    BLAST
    Transmembranei140 – 16021HelicalUniRule annotationAdd
    BLAST
    Transmembranei185 – 20521HelicalUniRule annotationAdd
    BLAST
    Transmembranei210 – 23021HelicalUniRule annotationAdd
    BLAST
    Transmembranei239 – 25921HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiWFIIVAT.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2RKY8-1 [UniParc]FASTAAdd to Basket

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    MTVLQAIVLG LVQGVGEFLP ISSSAHLILT PWFFRWPDPG LTFDVALHLG    50
    TLIAVVAYFW RDIIELVLSG LGQPRSQDGR LFWYLIVASI PGAIFGVLFE 100
    KQAETIFRSP LLIALTLTLM GLGLWWADRV GRKRRQLDDV NLFDGIIVGI 150
    SQALAIIPGV SRSGITMTAG LLTGMERETA ARFSFLMSVP IIAGAALLKL 200
    KELPLHEVNL AFIAGVLTAA VVGFLAIKFL LQYLRRGSYL LFTGYRILLA 250
    ALIVAVFWLR R 261
    Length:261
    Mass (Da):28,734
    Last modified:January 24, 2006 - v1
    Checksum:i398503AAEBE90D42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000232 Genomic DNA. Translation: ABC18901.1.
    RefSeqiWP_011392108.1. NC_007644.1.
    YP_429444.1. NC_007644.1.

    Genome annotation databases

    EnsemblBacteriaiABC18901; ABC18901; Moth_0571.
    GeneIDi3832484.
    KEGGimta:Moth_0571.
    PATRICi22638247. VBIMooThe6753_0614.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000232 Genomic DNA. Translation: ABC18901.1 .
    RefSeqi WP_011392108.1. NC_007644.1.
    YP_429444.1. NC_007644.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264732.Moth_0571.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC18901 ; ABC18901 ; Moth_0571 .
    GeneIDi 3832484.
    KEGGi mta:Moth_0571.
    PATRICi 22638247. VBIMooThe6753_0614.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi WFIIVAT.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci MTHE264732:GH0A-603-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39073.

    Entry informationi

    Entry nameiUPPP_MOOTA
    AccessioniPrimary (citable) accession number: Q2RKY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3