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Q2RKY8

- UPPP_MOOTA

UniProt

Q2RKY8 - UPPP_MOOTA

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, Moth_0571
Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMTHE264732:GH0A-603-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Moth_0571
OrganismiMoorella thermoacetica (strain ATCC 39073)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
ProteomesiUP000007053: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed predictionAdd
BLAST
Transmembranei40 – 6021Helical; Reviewed predictionAdd
BLAST
Transmembranei79 – 9921Helical; Reviewed predictionAdd
BLAST
Transmembranei106 – 12621Helical; Reviewed predictionAdd
BLAST
Transmembranei140 – 16021Helical; Reviewed predictionAdd
BLAST
Transmembranei185 – 20521Helical; Reviewed predictionAdd
BLAST
Transmembranei210 – 23021Helical; Reviewed predictionAdd
BLAST
Transmembranei239 – 25921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Undecaprenyl-diphosphataseUniRule annotationPRO_0000250245Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_0571.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiWFIIVAT.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2RKY8-1 [UniParc]FASTAAdd to Basket

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MTVLQAIVLG LVQGVGEFLP ISSSAHLILT PWFFRWPDPG LTFDVALHLG    50
TLIAVVAYFW RDIIELVLSG LGQPRSQDGR LFWYLIVASI PGAIFGVLFE 100
KQAETIFRSP LLIALTLTLM GLGLWWADRV GRKRRQLDDV NLFDGIIVGI 150
SQALAIIPGV SRSGITMTAG LLTGMERETA ARFSFLMSVP IIAGAALLKL 200
KELPLHEVNL AFIAGVLTAA VVGFLAIKFL LQYLRRGSYL LFTGYRILLA 250
ALIVAVFWLR R 261
Length:261
Mass (Da):28,734
Last modified:January 24, 2006 - v1
Checksum:i398503AAEBE90D42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000232 Genomic DNA. Translation: ABC18901.1.
RefSeqiWP_011392108.1. NC_007644.1.
YP_429444.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC18901; ABC18901; Moth_0571.
GeneIDi3832484.
KEGGimta:Moth_0571.
PATRICi22638247. VBIMooThe6753_0614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000232 Genomic DNA. Translation: ABC18901.1 .
RefSeqi WP_011392108.1. NC_007644.1.
YP_429444.1. NC_007644.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264732.Moth_0571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC18901 ; ABC18901 ; Moth_0571 .
GeneIDi 3832484.
KEGGi mta:Moth_0571.
PATRICi 22638247. VBIMooThe6753_0614.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi WFIIVAT.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci MTHE264732:GH0A-603-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39073.

Entry informationi

Entry nameiUPPP_MOOTA
AccessioniPrimary (citable) accession number: Q2RKY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi