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Protein

Phosphoenolpyruvate carboxykinase (ATP) 1

Gene

pckA1

Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.UniRule annotation

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55SubstrateUniRule annotation1
Binding sitei190SubstrateUniRule annotation1
Metal bindingi196ManganeseUniRule annotation1
Binding sitei196ATPUniRule annotation1
Binding sitei196SubstrateUniRule annotation1
Metal bindingi215Manganese; via tele nitrogenUniRule annotation1
Binding sitei215ATPUniRule annotation1
Metal bindingi252ManganeseUniRule annotation1
Binding sitei280ATPUniRule annotation1
Binding sitei317ATPUniRule annotation1
Binding sitei317SubstrateUniRule annotation1
Binding sitei442ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi231 – 239ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processGluconeogenesis
LigandATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE264732:G1G5J-669-MONOMER
UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase (ATP) 1UniRule annotation (EC:4.1.1.49UniRule annotation)
Short name:
PCK 1UniRule annotation
Short name:
PEP carboxykinase 1UniRule annotation
Short name:
PEPCK 1UniRule annotation
Gene namesi
Name:pckA1UniRule annotation
Ordered Locus Names:Moth_0633
OrganismiMoorella thermoacetica (strain ATCC 39073 / JCM 9320)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
Proteomesi
  • UP000007053 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002369281 – 525Phosphoenolpyruvate carboxykinase (ATP) 1Add BLAST525

Proteomic databases

PRIDEiQ2RKS7

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_0633

Structurei

3D structure databases

ProteinModelPortaliQ2RKS7
SMRiQ2RKS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DJ1 Bacteria
COG1866 LUCA
HOGENOMiHOG000271471
KOiK01610
OMAiMRYAGEM
OrthoDBiPOG091H03CD

Family and domain databases

CDDicd00484 PEPCK_ATP, 1 hit
Gene3Di3.40.449.10, 2 hits
3.90.228.20, 2 hits
HAMAPiMF_00453 PEPCK_ATP, 1 hit
InterProiView protein in InterPro
IPR001272 PEP_carboxykinase_ATP
IPR013035 PEP_carboxykinase_C
IPR008210 PEP_carboxykinase_N
IPR015994 PEPCK_ATP_CS
PANTHERiPTHR30031 PTHR30031, 1 hit
PfamiView protein in Pfam
PF01293 PEPCK_ATP, 1 hit
PIRSFiPIRSF006294 PEP_crbxkin, 1 hit
SUPFAMiSSF68923 SSF68923, 1 hit
TIGRFAMsiTIGR00224 pckA, 1 hit
PROSITEiView protein in PROSITE
PS00532 PEPCK_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

Q2RKS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTYGLERL GIINPGTIYR NLPMARLVEI ALARGEGLLA SNGALSVNTG
60 70 80 90 100
KYTGRSPHDR YIVDTPAVHD SISWGAVNQP VSEATFERLY SRLTAYLQGK
110 120 130 140 150
DLFVFDGFVG ADPAYRMPIR IVNEYAWQNL FVHQLFIRPT AEELAGHEPR
160 170 180 190 200
FTVICAPGFK AIPEEDGTRS EAFIILNFDR RLVIIGGTSY AGEMKKSIFT
210 220 230 240 250
VMNYLLPEQG VCPMHCSANM GPAGDTALFF GLSGTGKTTL SADPERYLIG
260 270 280 290 300
DDEHGWSDKG IFNFEGGCYA KCIKLSAEHE PQIWNAIRFG SVLENVMVDP
310 320 330 340 350
DCRIIDYDSD ALTENTRAAY PVDFIPNAVI PGVGGHPQTV VFLTADAFGV
360 370 380 390 400
MPPIAKLTRE QAMYYFLSGY TSKLAGTERG VTEPKATFST CFGAPFLPRS
410 420 430 440 450
PMVYANLLGE RIARHNASVY LVNTGWTGGP YGTGRRMSLP YTRAMVRAAL
460 470 480 490 500
NGELDKVEFT PDPVFGFLVP KACPGVPAEI LNPRNTWAET EKYDAMARKL
510 520
ASLFRENFAK FKDVPVSIQE AGVVG
Length:525
Mass (Da):57,646
Last modified:January 24, 2006 - v1
Checksum:i3544D0360ED1BFE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA Translation: ABC18962.1
RefSeqiWP_011392169.1, NC_007644.1
YP_429505.1, NC_007644.1

Genome annotation databases

EnsemblBacteriaiABC18962; ABC18962; Moth_0633
GeneIDi3832531
KEGGimta:Moth_0633
PATRICifig|264732.11.peg.680

Similar proteinsi

Entry informationi

Entry nameiPCKA1_MOOTA
AccessioniPrimary (citable) accession number: Q2RKS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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