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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241UniRule annotation1
Active sitei268UniRule annotation1
Active sitei365UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:Moth_0743
OrganismiMoorella thermoacetica (strain ATCC 39073 / JCM 9320)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
Proteomesi
  • UP000007053 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642911 – 424Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei574-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_0743.

Structurei

3D structure databases

ProteinModelPortaliQ2RKH8.
SMRiQ2RKH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 123Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini229 – 423CheB-type methylesteraseUniRule annotationAdd BLAST195

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiMLEMHRA.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2RKH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWPVRVLVV DDSAFSRRLV TDILQADPDI QVVGYARNGR EALEKVASLQ
60 70 80 90 100
PRVVTLDQEM PVMDGLTTLT ALMAGNPVAV IMLSSHTAAG AAVTIKALEL
110 120 130 140 150
GAVDFIPKPA PGDSLDDFTR QLTEKVKAAA RVPVTRLCRG KNCRENTPAP
160 170 180 190 200
FISPRPGREE AVAAVTGSAA ATAAIGSRLS PGRSPGGKEG VAGAVSAGST
210 220 230 240 250
RGEAIRPGKG TPAAIKGAVA AGAGRLPGRR PGIEVVAIGT STGGPAALRQ
260 270 280 290 300
VLTALPGNLP AGIVIVQHMP AGFTGPLARR LDELAALEVR EAAAGDILRP
310 320 330 340 350
GLALLAPAGR QMLLERHGDA VQVHLAAEAG ITTLFKPSVD ALFLTVAREY
360 370 380 390 400
GPRSLGVILT GMGNDGLRGL RAIKEQGGTV IAQDEATSVV YGMPRAAVEA
410 420
GLADLVLPLE DIAPAIVALV TGAG
Length:424
Mass (Da):43,300
Last modified:January 24, 2006 - v1
Checksum:i8EBEF555A2644F73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC19061.1.
RefSeqiWP_011392264.1. NC_007644.1.
YP_429604.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC19061; ABC19061; Moth_0743.
GeneIDi3831135.
KEGGimta:Moth_0743.
PATRICifig|264732.11.peg.798.

Similar proteinsi

Entry informationi

Entry nameiCHEB_MOOTA
AccessioniPrimary (citable) accession number: Q2RKH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: November 22, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome