SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2RK34

- DAPF_MOOTA

UniProt

Q2RK34 - DAPF_MOOTA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Diaminopimelate epimerase

Gene
dapF, Moth_0888
Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei45 – 451Substrate By similarity
Binding sitei63 – 631Substrate By similarity
Active sitei72 – 721Proton donor/acceptor By similarity
Binding sitei161 – 1611Substrate By similarity
Sitei163 – 1631Important for catalytic activity By similarity
Binding sitei194 – 1941Substrate By similarity
Sitei212 – 2121Important for catalytic activity By similarity
Active sitei221 – 2211Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciMTHE264732:GH0A-924-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:Moth_0888
OrganismiMoorella thermoacetica (strain ATCC 39073)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
ProteomesiUP000007053: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Diaminopimelate epimeraseUniRule annotationPRO_1000099248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi72 ↔ 221UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_0888.

Structurei

3D structure databases

ProteinModelPortaliQ2RK34.
SMRiQ2RK34. Positions 1-277.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 92Substrate binding By similarity
Regioni72 – 743Substrate binding By similarity
Regioni212 – 2132Substrate binding By similarity
Regioni222 – 2232Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220467.
KOiK01778.
OMAiKMRIFNN.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2RK34-1 [UniParc]FASTAAdd to Basket

« Hide

MHFVKMHGLG NDFVLVNAMT EKVPGDLPGL ARRVCHRRFG IGADGLILVL    50
PSEQARLRMR IFNPDGSEPE MCGNGIRCFA RYVYETGLAE GEELQVETLA 100
GIIKPRLILE GGRVAGVRVD MGAPHLEREQ IPMAGTGSPV LDEPIEVNGE 150
TWRGTCVSMG NPHCVFFVED VTGAPVTTVG PVVEHHPLFP RRTNVEFIQV 200
LNREELRMRV WERGAGETMA CGTGACAAAV AGALTGRSNR KVTVHLAAGD 250
LQIEWSPVDN HVYMTGPAVE VFRGDFPLD 279
Length:279
Mass (Da):30,377
Last modified:January 24, 2006 - v1
Checksum:i6210D4C93308E38E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000232 Genomic DNA. Translation: ABC19205.1.
RefSeqiWP_011392407.1. NC_007644.1.
YP_429748.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC19205; ABC19205; Moth_0888.
GeneIDi3831429.
KEGGimta:Moth_0888.
PATRICi22638934. VBIMooThe6753_0955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000232 Genomic DNA. Translation: ABC19205.1 .
RefSeqi WP_011392407.1. NC_007644.1.
YP_429748.1. NC_007644.1.

3D structure databases

ProteinModelPortali Q2RK34.
SMRi Q2RK34. Positions 1-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264732.Moth_0888.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC19205 ; ABC19205 ; Moth_0888 .
GeneIDi 3831429.
KEGGi mta:Moth_0888.
PATRICi 22638934. VBIMooThe6753_0955.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220467.
KOi K01778.
OMAi KMRIFNN.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci MTHE264732:GH0A-924-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39073.

Entry informationi

Entry nameiDAPF_MOOTA
AccessioniPrimary (citable) accession number: Q2RK34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi