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Q2RK34

- DAPF_MOOTA

UniProt

Q2RK34 - DAPF_MOOTA

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Binding sitei45 – 451SubstrateUniRule annotation
    Binding sitei63 – 631SubstrateUniRule annotation
    Active sitei72 – 721Proton donor/acceptorUniRule annotation
    Binding sitei161 – 1611SubstrateUniRule annotation
    Sitei163 – 1631Important for catalytic activityUniRule annotation
    Binding sitei194 – 1941SubstrateUniRule annotation
    Sitei212 – 2121Important for catalytic activityUniRule annotation
    Active sitei221 – 2211Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciMTHE264732:GH0A-924-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:Moth_0888
    OrganismiMoorella thermoacetica (strain ATCC 39073)
    Taxonomic identifieri264732 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
    ProteomesiUP000007053: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Diaminopimelate epimerasePRO_1000099248Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi72 ↔ 221

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi264732.Moth_0888.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2RK34.
    SMRiQ2RK34. Positions 1-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni8 – 92Substrate bindingUniRule annotation
    Regioni72 – 743Substrate bindingUniRule annotation
    Regioni212 – 2132Substrate bindingUniRule annotation
    Regioni222 – 2232Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    HOGENOMiHOG000220467.
    KOiK01778.
    OMAiKMRIFNN.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2RK34-1 [UniParc]FASTAAdd to Basket

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    MHFVKMHGLG NDFVLVNAMT EKVPGDLPGL ARRVCHRRFG IGADGLILVL    50
    PSEQARLRMR IFNPDGSEPE MCGNGIRCFA RYVYETGLAE GEELQVETLA 100
    GIIKPRLILE GGRVAGVRVD MGAPHLEREQ IPMAGTGSPV LDEPIEVNGE 150
    TWRGTCVSMG NPHCVFFVED VTGAPVTTVG PVVEHHPLFP RRTNVEFIQV 200
    LNREELRMRV WERGAGETMA CGTGACAAAV AGALTGRSNR KVTVHLAAGD 250
    LQIEWSPVDN HVYMTGPAVE VFRGDFPLD 279
    Length:279
    Mass (Da):30,377
    Last modified:January 24, 2006 - v1
    Checksum:i6210D4C93308E38E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000232 Genomic DNA. Translation: ABC19205.1.
    RefSeqiWP_011392407.1. NC_007644.1.
    YP_429748.1. NC_007644.1.

    Genome annotation databases

    EnsemblBacteriaiABC19205; ABC19205; Moth_0888.
    GeneIDi3831429.
    KEGGimta:Moth_0888.
    PATRICi22638934. VBIMooThe6753_0955.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000232 Genomic DNA. Translation: ABC19205.1 .
    RefSeqi WP_011392407.1. NC_007644.1.
    YP_429748.1. NC_007644.1.

    3D structure databases

    ProteinModelPortali Q2RK34.
    SMRi Q2RK34. Positions 1-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264732.Moth_0888.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC19205 ; ABC19205 ; Moth_0888 .
    GeneIDi 3831429.
    KEGGi mta:Moth_0888.
    PATRICi 22638934. VBIMooThe6753_0955.

    Phylogenomic databases

    eggNOGi COG0253.
    HOGENOMi HOG000220467.
    KOi K01778.
    OMAi KMRIFNN.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci MTHE264732:GH0A-924-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39073.

    Entry informationi

    Entry nameiDAPF_MOOTA
    AccessioniPrimary (citable) accession number: Q2RK34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3