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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi502MagnesiumUniRule annotation1
Metal bindingi508MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Moth_1056
OrganismiMoorella thermoacetica (strain ATCC 39073 / JCM 9320)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
Proteomesi
  • UP000007053 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003297141 – 747Polyribonucleotide nucleotidyltransferaseAdd BLAST747

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_1056.

Structurei

3D structure databases

ProteinModelPortaliQ2RJL9.
SMRiQ2RJL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini569 – 628KHUniRule annotationAdd BLAST60
Domaini638 – 712S1 motifUniRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRYMHNYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2RJL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGVLRKTLV VAGRDLTLET GRLAKQAGGA VMVSYGGTMV LVTATASEEP
60 70 80 90 100
REGIDFFPLT VDYEERLYAA GKIPGGFIKR EGRPSEKAIL SARLIDRPIR
110 120 130 140 150
PLFPKFYRND VHVVATVMSV DQDCPPNVAG IIGASAALML SAIPFAGPIG
160 170 180 190 200
AVSVGLIDNR PVINPTLEED SRSSLNLTVA GTANAIMMVE AGAKEVPEDL
210 220 230 240 250
MLECIMQGHE EIKRIVAFIN EFRAEALAMG LAKEKPELVA PQLDPAWESR
260 270 280 290 300
VREIATPRLR EVIYRSRDEK WSKQERDKQL DACREEINNL ILEGQEEALA
310 320 330 340 350
ANPELPGLIK ELITKIEKEI VRRMILTEGI RVDGRTLEEI RPITCEVGVL
360 370 380 390 400
SRTHGSGLFT RGETQVLTVT TLGPISDEQI LDDLGVDESK RYMHHYNFPP
410 420 430 440 450
YSVGEARPIR APGRREIGHG ALAERALEPM IPSEEEFPYA IRLVSEVLGS
460 470 480 490 500
NGSTSMGSVC GSTLSLMDAG VPIKAPVAGV AMGLVKENDQ VAILTDIQGL
510 520 530 540 550
EDALGDMDFK VAGTKKGITA LQMDIKIAGI DRSILERALE QARRGRLFIL
560 570 580 590 600
DKILATIPEP RKELSPYAPR MLTITIDPDK IRDIIGPGGK IIKKIIEETG
610 620 630 640 650
VEIDVEDDGR VFIASTDAAA GERALKIIES LTQDVETGKV YNGKVTRVTD
660 670 680 690 700
FGAFVEVIPR VLGMPGKEGL VHISQLANER VEKVEDVVQE GDYILVKAIG
710 720 730 740
FDPQGRLKLS RKEALNESTV GEGGHRHFRR AGREGGHRGL NNRRQSR
Length:747
Mass (Da):81,687
Last modified:January 24, 2006 - v1
Checksum:i20B46C71A303CC3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC19370.1.
RefSeqiWP_011392570.1. NC_007644.1.
YP_429913.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC19370; ABC19370; Moth_1056.
GeneIDi3833320.
KEGGimta:Moth_1056.
PATRICifig|264732.11.peg.1137.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPNP_MOOTA
AccessioniPrimary (citable) accession number: Q2RJL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 24, 2006
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families