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Q2RJL9

- PNP_MOOTA

UniProt

Q2RJL9 - PNP_MOOTA

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi502 – 5021MagnesiumUniRule annotation
Metal bindingi508 – 5081MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMTHE264732:GH0A-1095-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Moth_1056
OrganismiMoorella thermoacetica (strain ATCC 39073)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
ProteomesiUP000007053: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Polyribonucleotide nucleotidyltransferasePRO_0000329714Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_1056.

Structurei

3D structure databases

ProteinModelPortaliQ2RJL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini569 – 62860KHUniRule annotationAdd
BLAST
Domaini638 – 71275S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2RJL9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQGVLRKTLV VAGRDLTLET GRLAKQAGGA VMVSYGGTMV LVTATASEEP
60 70 80 90 100
REGIDFFPLT VDYEERLYAA GKIPGGFIKR EGRPSEKAIL SARLIDRPIR
110 120 130 140 150
PLFPKFYRND VHVVATVMSV DQDCPPNVAG IIGASAALML SAIPFAGPIG
160 170 180 190 200
AVSVGLIDNR PVINPTLEED SRSSLNLTVA GTANAIMMVE AGAKEVPEDL
210 220 230 240 250
MLECIMQGHE EIKRIVAFIN EFRAEALAMG LAKEKPELVA PQLDPAWESR
260 270 280 290 300
VREIATPRLR EVIYRSRDEK WSKQERDKQL DACREEINNL ILEGQEEALA
310 320 330 340 350
ANPELPGLIK ELITKIEKEI VRRMILTEGI RVDGRTLEEI RPITCEVGVL
360 370 380 390 400
SRTHGSGLFT RGETQVLTVT TLGPISDEQI LDDLGVDESK RYMHHYNFPP
410 420 430 440 450
YSVGEARPIR APGRREIGHG ALAERALEPM IPSEEEFPYA IRLVSEVLGS
460 470 480 490 500
NGSTSMGSVC GSTLSLMDAG VPIKAPVAGV AMGLVKENDQ VAILTDIQGL
510 520 530 540 550
EDALGDMDFK VAGTKKGITA LQMDIKIAGI DRSILERALE QARRGRLFIL
560 570 580 590 600
DKILATIPEP RKELSPYAPR MLTITIDPDK IRDIIGPGGK IIKKIIEETG
610 620 630 640 650
VEIDVEDDGR VFIASTDAAA GERALKIIES LTQDVETGKV YNGKVTRVTD
660 670 680 690 700
FGAFVEVIPR VLGMPGKEGL VHISQLANER VEKVEDVVQE GDYILVKAIG
710 720 730 740
FDPQGRLKLS RKEALNESTV GEGGHRHFRR AGREGGHRGL NNRRQSR
Length:747
Mass (Da):81,687
Last modified:January 24, 2006 - v1
Checksum:i20B46C71A303CC3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC19370.1.
RefSeqiYP_429913.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC19370; ABC19370; Moth_1056.
GeneIDi3833320.
KEGGimta:Moth_1056.
PATRICi22639300. VBIMooThe6753_1137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC19370.1 .
RefSeqi YP_429913.1. NC_007644.1.

3D structure databases

ProteinModelPortali Q2RJL9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264732.Moth_1056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC19370 ; ABC19370 ; Moth_1056 .
GeneIDi 3833320.
KEGGi mta:Moth_1056.
PATRICi 22639300. VBIMooThe6753_1137.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci MTHE264732:GH0A-1095-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39073.

Entry informationi

Entry nameiPNP_MOOTA
AccessioniPrimary (citable) accession number: Q2RJL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 24, 2006
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3