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Protein

Homoserine O-acetyltransferase

Gene

metXA

Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.UniRule annotation

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metXA)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei151NucleophileUniRule annotation1
Binding sitei220SubstrateUniRule annotation1
Active sitei314UniRule annotation1
Active sitei347UniRule annotation1
Binding sitei348SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.

Protein family/group databases

ESTHERimoota-metx. Homoserine_transacetylase.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Short name:
HATUniRule annotation
Alternative name(s):
Homoserine transacetylaseUniRule annotation
Short name:
HTAUniRule annotation
Gene namesi
Name:metXAUniRule annotation
Ordered Locus Names:Moth_1308
OrganismiMoorella thermoacetica (strain ATCC 39073 / JCM 9320)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
Proteomesi
  • UP000007053 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002318731 – 374Homoserine O-acetyltransferaseAdd BLAST374

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi264732.Moth_1308.

Structurei

3D structure databases

ProteinModelPortaliQ2RIW8.
SMRiQ2RIW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 353AB hydrolase-1UniRule annotationAdd BLAST309

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MetX family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiCQGTTGP.
OrthoDBiPOG091H08NY.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. MetX_acyltransf. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. HAT_MetX-like.
PfamiView protein in Pfam
PF00561. Abhydrolase_1. 1 hit.
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2RIW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGVGIVTTR FYEWSQCLHL ESGAQLGSLT IAYETYGELN AAGNNAILVL
60 70 80 90 100
HALTGNAHIA GRNFPDERYP GWWDPLVGPG RALDTRRYFI VCANVLGSCY
110 120 130 140 150
GTTGPASINP ATGKPYGMDF PAITIRDMVR AQKILLDYLG VKRLVAAIGG
160 170 180 190 200
SMGGMQVLEW GFLYPQMLDA IIPIATCGRT TPMQIAFHHV QREAIYADPD
210 220 230 240 250
WQGGNYYGTA GPRRGLALAR QIGIITYKSD PSWNMKFGRN LVDPRKYFQL
260 270 280 290 300
EGQFEVESYL AYQGRKLVDR FDANSYLYLT KAVDLHDVSQ GRGSYNEVWR
310 320 330 340 350
DFPCPCLGIG ISSDFLFPPY QVQEIVRMIN DGGGHARYAE IDSPYGHDAF
360 370
LIEFNQLAAI IQPFLKELRP DLAA
Length:374
Mass (Da):41,585
Last modified:January 24, 2006 - v1
Checksum:iA32FD4C76CF341E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC19621.1.
RefSeqiWP_011392821.1. NC_007644.1.
YP_430164.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC19621; ABC19621; Moth_1308.
GeneIDi3831794.
KEGGimta:Moth_1308.
PATRICifig|264732.11.peg.1405.

Similar proteinsi

Entry informationi

Entry nameiMETXA_MOOTA
AccessioniPrimary (citable) accession number: Q2RIW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: August 30, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families