Reviewed, UniProtKB/Swiss-Prot Q2RIU8 (IDI2_MOOTA)

Names and origin

Protein names

Recommended name:
    Isopentenyl-diphosphate delta-isomerase
      Short name=IPP isomerase
    EC=5.3.3.2
Alternative name(s):
    Isopentenyl pyrophosphate isomerase

Gene names

Name:	fni
Ordered Locus Names:	Moth_1328

Organism

Moorella thermoacetica (strain ATCC 39073) [Complete proteome] [HAMAP]

Taxonomic identifier

264732 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Moorella group › Moorella

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity.
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP MF_00354
Cofactor	FMN By similarity. NADPH By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein NADP
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Isopentenyl-diphosphate delta-isomerase HAMAP MF_00354		PRO_0000229505

Sequences

	Sequence		Length	Mass (Da)
	Q2RIU8-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 5730A1FD40989742	FASTA	346	37,305
	10 20 30 40 50 60 MNEREYIGRG RRKLEHLRFF QEDSKGSNGL EDVHLVHQAL PELNWSDIDL TCRWLGKTLA 70 80 90 100 110 120 APFIINALTG GPPETLAINA ALARVARRTG IALAVGSQRA GLENKEWRES FTIVRRENAN 130 140 150 160 170 180 GLILANIGAG NSPADAGEAV AMIAADGLQV HLNAAQELIM PEGDRAFRGW LENIRGMVNT 190 200 210 220 230 240 LGVPVIAKEV GFGLSRETAL QLYQAGVRIM DVGGRGGTNF AAIEERRRGR SVAALAGWGL 250 260 270 280 290 300 STAVSILEIR ELGLPVEVVA TGGIRSALDA ARALALGAKI VGAAGYFLKI LLEQGEDALT 310 320 330 340 EEILQWQEDL KRICLLTGCT TPAELATKPV VITGQTRAWL EGRQRH

References

[1]

"The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)." Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C., Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W. Environ. Microbiol. 10:2550-2573(2008) [PubMed: 18631365] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000232 Genomic DNA. Translation: ABC19641.1.
RefSeq	YP_430184.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3831038.
GenomeReviews	Gene locus Moth_1328 in contig CP000232_GR.
KEGG	mta:Moth_1328.
NMPDR	fig|264732.9.peg.1323.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2RIU8.
OMA	Q2RIU8. AMGVGSQ.
Enzyme and pathway databases
BioCyc	MTHE264732:MOTH_1328-MON.
Family and domain databases
HAMAP	MF_00354. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011179. IPdP_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10578:SF3. IPdP_isomerase. 1 hit.
PIRSF	PIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMs	TIGR02151. IPP_isom_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI2_MOOTA

Accession

Primary (citable) accession number: Q2RIU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	January 24, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)