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Protein

NAD kinase

Gene

nadK

Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Proton acceptorUniRule annotation1
Binding sitei72NADUniRule annotation1
Binding sitei151NADUniRule annotation1
Binding sitei170NADUniRule annotation1
Binding sitei240NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 68NADUniRule annotation2
Nucleotide bindingi140 – 141NADUniRule annotation2
Nucleotide bindingi181 – 186NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE264732:G1G5J-1566-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Moth_1509
OrganismiMoorella thermoacetica (strain ATCC 39073 / JCM 9320)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
Proteomesi
  • UP000007053 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296541 – 311NAD kinaseAdd BLAST311

Proteomic databases

PRIDEiQ2RIC1

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_1509

Structurei

3D structure databases

ProteinModelPortaliQ2RIC1
SMRiQ2RIC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q2RIC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRIGMVANL EKPRVRETAL DIINYLESRN VRVLISTRKA AALGCPEKGV
60 70 80 90 100
AEEEVIAAEG LLALGGDGTL LRAARLVAPA GTPILGINLG HLGFLTEIEL
110 120 130 140 150
TELYPALDKL LAGAYRIEER MMLRGTVQRP EKALTCTALN DIVVTKGAFS
160 170 180 190 200
RMLRLEVYID TAYLDTYPAD GLIVSSPTGS TAYSLSAGGP LVSPQLQVMI
210 220 230 240 250
LTPICPHTLY TRPLVVPGEQ EIRVCVHAPG AEVMLTVDGQ QGLHLRDGDV
260 270 280 290 300
IRVTRARTPA RLIRLQDNTF YSLVREKLKE GGSRQDDENP AATVNPETDS
310
KYPHSHPGST G
Length:311
Mass (Da):33,684
Last modified:January 24, 2006 - v1
Checksum:iEDA72D2B0CFDD54D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA Translation: ABC19818.1
RefSeqiWP_011393018.1, NC_007644.1
YP_430361.1, NC_007644.1

Genome annotation databases

EnsemblBacteriaiABC19818; ABC19818; Moth_1509
GeneIDi3831974
KEGGimta:Moth_1509
PATRICifig|264732.11.peg.1635

Similar proteinsi

Entry informationi

Entry nameiNADK_MOOTA
AccessioniPrimary (citable) accession number: Q2RIC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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