Q2RHL2 (ACDH_MOOTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]

Gene names

Ordered Locus Names:

Moth_1776

Organism

Moorella thermoacetica (strain ATCC 39073)

Taxonomic identifier

264732 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Moorella group › Moorella

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Acetaldehyde dehydrogenase HAMAP MF_01657		PRO_0000387669
Regions
	Nucleotide binding	155 – 163	9	NAD By similarity
Sites
	Binding site	265	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2RHL2 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 8AA1B3C4474AA82F	FASTA	291	30,795
	10 20 30 40 50 60 MDKVKVAVIG PGNIGSDLMY KILRSRHLEM ALMTGIIESE GIKRARKLGI KTSIEGVKAV 70 80 90 100 110 120 LAEDDIKIVF DATGAKPHLQ HAPLLKEAGK IAIDLTPAAV GPYVVPCVNL DQVKAEPNLN 130 140 150 160 170 180 MVTCGGQATV PIVYAINRVA GARYAEIVAC IASKSAGPGT RQNIDEFTQT TAKALEVVGG 190 200 210 220 230 240 AKKGKAIIIL NPAEPPIMMH NTIYVEVEKP DIEAIRASVE AMVKEIQSYV PGYRLVVPPI 250 260 270 280 290 LDGNKVTAAV EVEGAGDFLP KYSGNLDIIT SAAVAVAEKL AQELQVKEGV A

References

[1]

"The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)." Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C., Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W. Environ. Microbiol. 10:2550-2573(2008) [PubMed: 18631365] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39073.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000232 Genomic DNA. Translation: ABC20077.1.
RefSeq	YP_430620.1. NC_007644.1.
3D structure databases
ProteinModelPortal	Q2RHL2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2RHL2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3832442.
GenomeReviews	Gene locus Moth_1776 in contig CP000232_GR.
KEGG	mta:Moth_1776.
NMPDR	fig|264732.9.peg.1783.
PATRIC	22640900. VBIMooThe6753_1927.
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HBG300125.
OMA	HVKNDAF.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	MTHE264732:MOTH_1776-MONOMER.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K04073.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH_MOOTA

Accession

Primary (citable) accession number: Q2RHL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program