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Q2RHL2

- ACDH_MOOTA

UniProt

Q2RHL2 - ACDH_MOOTA

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Protein

Acetaldehyde dehydrogenase

Gene

Moth_1776

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei124 – 1241Acyl-thioester intermediateUniRule annotation
Binding sitei265 – 2651NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi155 – 1639NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMTHE264732:GH0A-1838-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:Moth_1776
OrganismiMoorella thermoacetica (strain ATCC 39073)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
ProteomesiUP000007053: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Acetaldehyde dehydrogenasePRO_0000387669Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_1776.

Structurei

3D structure databases

ProteinModelPortaliQ2RHL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHQGNVNM.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2RHL2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKVKVAVIG PGNIGSDLMY KILRSRHLEM ALMTGIIESE GIKRARKLGI
60 70 80 90 100
KTSIEGVKAV LAEDDIKIVF DATGAKPHLQ HAPLLKEAGK IAIDLTPAAV
110 120 130 140 150
GPYVVPCVNL DQVKAEPNLN MVTCGGQATV PIVYAINRVA GARYAEIVAC
160 170 180 190 200
IASKSAGPGT RQNIDEFTQT TAKALEVVGG AKKGKAIIIL NPAEPPIMMH
210 220 230 240 250
NTIYVEVEKP DIEAIRASVE AMVKEIQSYV PGYRLVVPPI LDGNKVTAAV
260 270 280 290
EVEGAGDFLP KYSGNLDIIT SAAVAVAEKL AQELQVKEGV A
Length:291
Mass (Da):30,795
Last modified:January 24, 2006 - v1
Checksum:i8AA1B3C4474AA82F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC20077.1.
RefSeqiYP_430620.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC20077; ABC20077; Moth_1776.
GeneIDi3832442.
KEGGimta:Moth_1776.
PATRICi22640900. VBIMooThe6753_1927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC20077.1 .
RefSeqi YP_430620.1. NC_007644.1.

3D structure databases

ProteinModelPortali Q2RHL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264732.Moth_1776.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC20077 ; ABC20077 ; Moth_1776 .
GeneIDi 3832442.
KEGGi mta:Moth_1776.
PATRICi 22640900. VBIMooThe6753_1927.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi HQGNVNM.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci MTHE264732:GH0A-1838-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39073.

Entry informationi

Entry nameiACDH_MOOTA
AccessioniPrimary (citable) accession number: Q2RHL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3