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Q2RH48

- GCSPA_MOOTA

UniProt

Q2RH48 - GCSPA_MOOTA

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMTHE264732:GH0A-2014-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Moth_1943
OrganismiMoorella thermoacetica (strain ATCC 39073)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
ProteomesiUP000007053: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045669Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi264732.Moth_1943.

Structurei

3D structure databases

ProteinModelPortaliQ2RH48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2RH48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTYIPTTAAE QQQMLAACGA HRMEELFSDV PASVRLGREL NLPRPMAEAE
60 70 80 90 100
VWRHLEELAG KNKKLVSFLG AGAYEHYIPS VVGHLLARSE FYTAYTPYQP
110 120 130 140 150
EISQGTLQAI FEFQSLICEL TGLDVATASH YDGATAMAEA ALVACNATRR
160 170 180 190 200
QKILVSRSVN PQYRTVLSTY AKGQGVELAE VPLQDGRTDL EALEKLAGKD
210 220 230 240 250
VAGVILQNPN FFGQIEAMAE ATDLAHKARA LGIAVVDPVS LGLLAAPGEY
260 270 280 290 300
GADLAVGEGQ SLGNPLNFGG PYLGFIAARE KLVRRLPGRI VGQTKDVDGK
310 320 330 340 350
RAYVLTLQAR EQHIRREKAT SNICSNEALC ALAATIYLAA MGREGLKEVA
360 370 380 390 400
SQCLLKAHYA QKKLAALPGV TPVFNGPFFH EFVLQTKLSP ATVARRLAEN
410 420 430 440
GFAAGFDLGR FYPELKNALL FTVTEVRTRE EIDALVAAMR GILA
Length:444
Mass (Da):48,030
Last modified:January 24, 2006 - v1
Checksum:i8508D45D24DE1705
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC20241.1.
RefSeqiWP_011393441.1. NC_007644.1.
YP_430784.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC20241; ABC20241; Moth_1943.
GeneIDi3832435.
KEGGimta:Moth_1943.
PATRICi22641276. VBIMooThe6753_2106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC20241.1 .
RefSeqi WP_011393441.1. NC_007644.1.
YP_430784.1. NC_007644.1.

3D structure databases

ProteinModelPortali Q2RH48.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264732.Moth_1943.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC20241 ; ABC20241 ; Moth_1943 .
GeneIDi 3832435.
KEGGi mta:Moth_1943.
PATRICi 22641276. VBIMooThe6753_2106.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci MTHE264732:GH0A-2014-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39073.

Entry informationi

Entry nameiGCSPA_MOOTA
AccessioniPrimary (citable) accession number: Q2RH48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3