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Q2RH48 (GCSPA_MOOTA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Moth_1943
OrganismMoorella thermoacetica (strain ATCC 39073) [Reference proteome] [HAMAP]
Taxonomic identifier264732 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045669

Sequences

Sequence LengthMass (Da)Tools
Q2RH48 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 8508D45D24DE1705

FASTA44448,030
        10         20         30         40         50         60 
MTYIPTTAAE QQQMLAACGA HRMEELFSDV PASVRLGREL NLPRPMAEAE VWRHLEELAG 

        70         80         90        100        110        120 
KNKKLVSFLG AGAYEHYIPS VVGHLLARSE FYTAYTPYQP EISQGTLQAI FEFQSLICEL 

       130        140        150        160        170        180 
TGLDVATASH YDGATAMAEA ALVACNATRR QKILVSRSVN PQYRTVLSTY AKGQGVELAE 

       190        200        210        220        230        240 
VPLQDGRTDL EALEKLAGKD VAGVILQNPN FFGQIEAMAE ATDLAHKARA LGIAVVDPVS 

       250        260        270        280        290        300 
LGLLAAPGEY GADLAVGEGQ SLGNPLNFGG PYLGFIAARE KLVRRLPGRI VGQTKDVDGK 

       310        320        330        340        350        360 
RAYVLTLQAR EQHIRREKAT SNICSNEALC ALAATIYLAA MGREGLKEVA SQCLLKAHYA 

       370        380        390        400        410        420 
QKKLAALPGV TPVFNGPFFH EFVLQTKLSP ATVARRLAEN GFAAGFDLGR FYPELKNALL 

       430        440 
FTVTEVRTRE EIDALVAAMR GILA 

« Hide

References

[1]"The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)."
Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C., Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W.
Environ. Microbiol. 10:2550-2573(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39073.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000232 Genomic DNA. Translation: ABC20241.1.
RefSeqYP_430784.1. NC_007644.1.

3D structure databases

ProteinModelPortalQ2RH48.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264732.Moth_1943.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC20241; ABC20241; Moth_1943.
GeneID3832435.
KEGGmta:Moth_1943.
PATRIC22641276. VBIMooThe6753_2106.

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycMTHE264732:GH0A-2014-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_MOOTA
AccessionPrimary (citable) accession number: Q2RH48
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families