Reviewed, UniProtKB/Swiss-Prot Q2RH48 (GCSPA_MOOTA)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	Moth_1943

Organism

Moorella thermoacetica (strain ATCC 39073) [Complete proteome] [HAMAP]

Taxonomic identifier

264732 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Moorella group › Moorella

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 444	444	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045669

Sequences

	Sequence		Length	Mass (Da)
	Q2RH48-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 8508D45D24DE1705	FASTA	444	48,030
	10 20 30 40 50 60 MTYIPTTAAE QQQMLAACGA HRMEELFSDV PASVRLGREL NLPRPMAEAE VWRHLEELAG 70 80 90 100 110 120 KNKKLVSFLG AGAYEHYIPS VVGHLLARSE FYTAYTPYQP EISQGTLQAI FEFQSLICEL 130 140 150 160 170 180 TGLDVATASH YDGATAMAEA ALVACNATRR QKILVSRSVN PQYRTVLSTY AKGQGVELAE 190 200 210 220 230 240 VPLQDGRTDL EALEKLAGKD VAGVILQNPN FFGQIEAMAE ATDLAHKARA LGIAVVDPVS 250 260 270 280 290 300 LGLLAAPGEY GADLAVGEGQ SLGNPLNFGG PYLGFIAARE KLVRRLPGRI VGQTKDVDGK 310 320 330 340 350 360 RAYVLTLQAR EQHIRREKAT SNICSNEALC ALAATIYLAA MGREGLKEVA SQCLLKAHYA 370 380 390 400 410 420 QKKLAALPGV TPVFNGPFFH EFVLQTKLSP ATVARRLAEN GFAAGFDLGR FYPELKNALL 430 440 FTVTEVRTRE EIDALVAAMR GILA

References

[1]

"The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)." Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C., Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W. Environ. Microbiol. 10:2550-2573(2008) [PubMed: 18631365] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000232 Genomic DNA. Translation: ABC20241.1.
RefSeq	YP_430784.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3832435.
GenomeReviews	Gene locus Moth_1943 in contig CP000232_GR.
KEGG	mta:Moth_1943.
NMPDR	fig|264732.9.peg.1952.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2RH48.
OMA	Q2RH48. VANASMY.
Enzyme and pathway databases
BioCyc	MTHE264732:MOTH_1943-MON.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_MOOTA

Accession

Primary (citable) accession number: Q2RH48

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 24, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)