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Q2RGX6 (THIM_MOOTA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:Moth_2017
OrganismMoorella thermoacetica (strain ATCC 39073) [Reference proteome] [HAMAP]
Taxonomic identifier264732 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_1000021523

Sites

Binding site461Substrate; via amide nitrogen By similarity
Binding site1221ATP By similarity
Binding site1681ATP By similarity
Binding site1951Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2RGX6 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: FDAEF4164D4F0BBD

FASTA26727,779
        10         20         30         40         50         60 
MNWGEQVASR RQRVHEQRPL VHHITNLVVT NLTANVTLAI GASPVMAYAR EEVADMARLA 

        70         80         90        100        110        120 
QAVVLNMGTL TGDVVEAMLL AGKAANNAGI PVVFDPVGAG ATPFRTRTAQ KIIKELHIDI 

       130        140        150        160        170        180 
LRGNASEIAS IGGFGGHTKG VDAAGAPARV AEMVKQVARD LNTVVAVTGA TDYISDGERL 

       190        200        210        220        230        240 
IAVDNGHPLL TFVTGTGCSA TSIIAAFRAV EEDGVTASTA ALAYYGLAAE RAAAVSQGPA 

       250        260 
SFQVALLDTL YNLAGEELAR GVKIRLL 

« Hide

References

[1]"The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)."
Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C., Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W.
Environ. Microbiol. 10:2550-2573(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39073.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000232 Genomic DNA. Translation: ABC20313.1.
RefSeqYP_430856.1. NC_007644.1.

3D structure databases

ProteinModelPortalQ2RGX6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264732.Moth_2017.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC20313; ABC20313; Moth_2017.
GeneID3831971.
KEGGmta:Moth_2017.
PATRIC22641442. VBIMooThe6753_2189.

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAQTFTANV.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycMTHE264732:GH0A-2093-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_MOOTA
AccessionPrimary (citable) accession number: Q2RGX6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways