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Q2RGV8

- HISX_MOOTA

UniProt

Q2RGV8 - HISX_MOOTA

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei124 – 1241NADUniRule annotation
    Binding sitei186 – 1861NADUniRule annotation
    Binding sitei209 – 2091NADUniRule annotation
    Binding sitei232 – 2321SubstrateUniRule annotation
    Metal bindingi254 – 2541ZincUniRule annotation
    Binding sitei254 – 2541SubstrateUniRule annotation
    Metal bindingi257 – 2571ZincUniRule annotation
    Binding sitei257 – 2571SubstrateUniRule annotation
    Active sitei322 – 3221Proton acceptorUniRule annotation
    Active sitei323 – 3231Proton acceptorUniRule annotation
    Binding sitei323 – 3231SubstrateUniRule annotation
    Metal bindingi356 – 3561ZincUniRule annotation
    Binding sitei356 – 3561SubstrateUniRule annotation
    Binding sitei410 – 4101SubstrateUniRule annotation
    Metal bindingi415 – 4151ZincUniRule annotation
    Binding sitei415 – 4151SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciMTHE264732:GH0A-2111-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:Moth_2035
    OrganismiMoorella thermoacetica (strain ATCC 39073)
    Taxonomic identifieri264732 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
    ProteomesiUP000007053: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Histidinol dehydrogenasePRO_0000229858Add
    BLAST

    Proteomic databases

    PRIDEiQ2RGV8.

    Interactioni

    Protein-protein interaction databases

    STRINGi264732.Moth_2035.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2RGV8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2RGV8-1 [UniParc]FASTAAdd to Basket

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    MLPLIDGKEV KRRWSGRLLA REGVAARVRE IIAAVKREGQ AAVERYTLEL    50
    DGVDLKEAGF RVTREEIGAA YRAVSPDLLE ALRIARDNIA TYHRRQPRGS 100
    WMETAADGTI LGQICRPLGR VGLYVPGGTA AYPSSVLMTA VPARVAGVRE 150
    IALATPPRRD GTLPPLLLVA AAEAGVEEIY KMGGAQAVAA LAYGTEKVAP 200
    VDKIAGPGNI YVTLAKKEVY GQVDIDMLAG PSEIVVIADG KARPDWVAAD 250
    LLSQAEHDAL AGAVLITPDA GLARAVGEEV TRQLEALPRR EIASRSLADY 300
    GAAVVVTGLD AAMDLANSLA PEHLELYVSE PWSWLGRVEN AGAIFLGPYS 350
    SEPLGDYLAG PSHVLPTGGT ARFYSPLSVD TFLKKSSLIA CNRAGFRAAA 400
    GYIQALARAE GLEGHARAIE LREE 424
    Length:424
    Mass (Da):45,045
    Last modified:January 24, 2006 - v1
    Checksum:i79066A42F74907AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000232 Genomic DNA. Translation: ABC20331.1.
    RefSeqiYP_430874.1. NC_007644.1.

    Genome annotation databases

    EnsemblBacteriaiABC20331; ABC20331; Moth_2035.
    GeneIDi3831410.
    KEGGimta:Moth_2035.
    PATRICi22641484. VBIMooThe6753_2210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000232 Genomic DNA. Translation: ABC20331.1 .
    RefSeqi YP_430874.1. NC_007644.1.

    3D structure databases

    ProteinModelPortali Q2RGV8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264732.Moth_2035.

    Proteomic databases

    PRIDEi Q2RGV8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC20331 ; ABC20331 ; Moth_2035 .
    GeneIDi 3831410.
    KEGGi mta:Moth_2035.
    PATRICi 22641484. VBIMooThe6753_2210.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci MTHE264732:GH0A-2111-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39073.

    Entry informationi

    Entry nameiHISX_MOOTA
    AccessioniPrimary (citable) accession number: Q2RGV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3