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Q2RGV8

- HISX_MOOTA

UniProt

Q2RGV8 - HISX_MOOTA

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241NADUniRule annotation
Binding sitei186 – 1861NADUniRule annotation
Binding sitei209 – 2091NADUniRule annotation
Binding sitei232 – 2321SubstrateUniRule annotation
Metal bindingi254 – 2541ZincUniRule annotation
Binding sitei254 – 2541SubstrateUniRule annotation
Metal bindingi257 – 2571ZincUniRule annotation
Binding sitei257 – 2571SubstrateUniRule annotation
Active sitei322 – 3221Proton acceptorUniRule annotation
Active sitei323 – 3231Proton acceptorUniRule annotation
Binding sitei323 – 3231SubstrateUniRule annotation
Metal bindingi356 – 3561ZincUniRule annotation
Binding sitei356 – 3561SubstrateUniRule annotation
Binding sitei410 – 4101SubstrateUniRule annotation
Metal bindingi415 – 4151ZincUniRule annotation
Binding sitei415 – 4151SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMTHE264732:GH0A-2111-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Moth_2035
OrganismiMoorella thermoacetica (strain ATCC 39073)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
ProteomesiUP000007053: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Histidinol dehydrogenasePRO_0000229858Add
BLAST

Proteomic databases

PRIDEiQ2RGV8.

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_2035.

Structurei

3D structure databases

ProteinModelPortaliQ2RGV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2RGV8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPLIDGKEV KRRWSGRLLA REGVAARVRE IIAAVKREGQ AAVERYTLEL
60 70 80 90 100
DGVDLKEAGF RVTREEIGAA YRAVSPDLLE ALRIARDNIA TYHRRQPRGS
110 120 130 140 150
WMETAADGTI LGQICRPLGR VGLYVPGGTA AYPSSVLMTA VPARVAGVRE
160 170 180 190 200
IALATPPRRD GTLPPLLLVA AAEAGVEEIY KMGGAQAVAA LAYGTEKVAP
210 220 230 240 250
VDKIAGPGNI YVTLAKKEVY GQVDIDMLAG PSEIVVIADG KARPDWVAAD
260 270 280 290 300
LLSQAEHDAL AGAVLITPDA GLARAVGEEV TRQLEALPRR EIASRSLADY
310 320 330 340 350
GAAVVVTGLD AAMDLANSLA PEHLELYVSE PWSWLGRVEN AGAIFLGPYS
360 370 380 390 400
SEPLGDYLAG PSHVLPTGGT ARFYSPLSVD TFLKKSSLIA CNRAGFRAAA
410 420
GYIQALARAE GLEGHARAIE LREE
Length:424
Mass (Da):45,045
Last modified:January 24, 2006 - v1
Checksum:i79066A42F74907AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000232 Genomic DNA. Translation: ABC20331.1.
RefSeqiWP_011393531.1. NC_007644.1.
YP_430874.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC20331; ABC20331; Moth_2035.
GeneIDi3831410.
KEGGimta:Moth_2035.
PATRICi22641484. VBIMooThe6753_2210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000232 Genomic DNA. Translation: ABC20331.1 .
RefSeqi WP_011393531.1. NC_007644.1.
YP_430874.1. NC_007644.1.

3D structure databases

ProteinModelPortali Q2RGV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264732.Moth_2035.

Proteomic databases

PRIDEi Q2RGV8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC20331 ; ABC20331 ; Moth_2035 .
GeneIDi 3831410.
KEGGi mta:Moth_2035.
PATRICi 22641484. VBIMooThe6753_2210.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci MTHE264732:GH0A-2111-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39073.

Entry informationi

Entry nameiHISX_MOOTA
AccessioniPrimary (citable) accession number: Q2RGV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3