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Q2RGU9

- PUR9_MOOTA

UniProt

Q2RGU9 - PUR9_MOOTA

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Moorella thermoacetica (strain ATCC 39073)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciMTHE264732:GH0A-2120-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Moth_2044
OrganismiMoorella thermoacetica (strain ATCC 39073)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
ProteomesiUP000007053: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Bifunctional purine biosynthesis protein PurHPRO_1000018909Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_2044.

Structurei

3D structure databases

ProteinModelPortaliQ2RGU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2RGU9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKRALISVS DKTGLVELAR GLVELGWELL STGGTARTLI AAGLPVTEVA
60 70 80 90 100
AVTGFPEILD GRVKTLHPKI HGGILARPTP EHLAQLQEQG IQPIDLVVVN
110 120 130 140 150
LYPFRETIAR PGVTPAEAIE NIDIGGPAMV RAAAKNHERV GIVVDPASYN
160 170 180 190 200
EVLTELREKG SLSPETRRRL AAAAFAHTAA YDAAIAAYFQ RLMRNEEPFP
210 220 230 240 250
ASFVLSGEKV QDLRYGENPH QGAAFYRLPA PPPGTLAGAR QLQGKELSYN
260 270 280 290 300
NLMDLDAAWN LACDFKEPVV AIIKHTNPCG VARASTPAAA YRLAYAADPV
310 320 330 340 350
SAFGGIVACN RPVDGEMAGA MTEIFLEAVI APSFTPEAMA ILKSKSNLRL
360 370 380 390 400
LAAGERAGCR TREYQIRPVS GGFLVQEPDY HVLEPESLKV VTARKPEAKE
410 420 430 440 450
MADLLFAWQV VKHVKSNAIV VARDGVTLGI GAGQMNRVGA ARIALEQAGA
460 470 480 490 500
RAKGAVLASD AFFPFGDTVE LAAGAGITAI IQPGGSIRDE ESIRAADAAG
510
IAMVFTGIRH FRH
Length:513
Mass (Da):54,593
Last modified:January 24, 2006 - v1
Checksum:i83F071C4E55605E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC20340.1.
RefSeqiYP_430883.1. NC_007644.1.

Genome annotation databases

EnsemblBacteriaiABC20340; ABC20340; Moth_2044.
GeneIDi3831190.
KEGGimta:Moth_2044.
PATRICi22641504. VBIMooThe6753_2220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA. Translation: ABC20340.1 .
RefSeqi YP_430883.1. NC_007644.1.

3D structure databases

ProteinModelPortali Q2RGU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264732.Moth_2044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC20340 ; ABC20340 ; Moth_2044 .
GeneIDi 3831190.
KEGGi mta:Moth_2044.
PATRICi 22641504. VBIMooThe6753_2220.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci MTHE264732:GH0A-2120-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39073.

Entry informationi

Entry nameiPUR9_MOOTA
AccessioniPrimary (citable) accession number: Q2RGU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3