Q2RG62 (ARGC_MOOTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Moth_2290

Organism

Moorella thermoacetica (strain ATCC 39073)

Taxonomic identifier

264732 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Moorella group › Moorella

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000011019
Sites
	Active site	150	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2RG62 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 6C6EAED5BE084DB2	FASTA	346	37,549
	10 20 30 40 50 60 MIKAGIIGAT GYTGAELVRI LSRHPEVELV ALTSRSYAGE GMAGVYPSLT GYTNLTCENL 70 80 90 100 110 120 TPDEVMDRAE VIFIALPHGH AVPVATRARE RGIKVIDLGA DWRFRNARTY EEWYKIQHGN 130 140 150 160 170 180 HELAARAVYG LPEIHREAIR SAGLVANPGC YPTSAILGLA PLLKGGYIDP ATIIIDAKSG 190 200 210 220 230 240 VSGAGREARV TSLFVECNES INPYGVASHR HTPEIEQELS ALAGKEVKVT FTPHLLPISR 250 260 270 280 290 300 GILSTMYATL VRPASTEELR RVYEKFYAGE PFVHLLPPGQ WPHTRWVYGS NNCHLNLAVD 310 320 330 340 TRTGRVVVAS AIDNLTKGAS GQAVQNLNLM CGFPETMALE VPGLCP

References

[1]

"The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)." Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C., Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W. Environ. Microbiol. 10:2550-2573(2008) [PubMed: 18631365] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39073.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000232 Genomic DNA. Translation: ABC20577.1.
RefSeq	YP_431120.1. NC_007644.1.
3D structure databases
HSSP	HSSP built from PDB template 1VKN based on UniProtKB Q9X2A2.
ProteinModelPortal	Q2RG62.
SMR	Q2RG62. Positions 1-346.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2RG62.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3831322.
GenomeReviews	Gene locus Moth_2290 in contig CP000232_GR.
KEGG	mta:Moth_2290.
NMPDR	fig|264732.9.peg.2327.
PATRIC	22642052. VBIMooThe6753_2494.
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	Q2RG62.
Enzyme and pathway databases
BioCyc	MTHE264732:MOTH_2290-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_MOOTA

Accession

Primary (citable) accession number: Q2RG62

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program