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Q2RFU7 (SYR_MOOTA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Moth_2410
OrganismMoorella thermoacetica (strain ATCC 39073) [Reference proteome] [HAMAP]
Taxonomic identifier264732 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242044

Regions

Motif135 – 14511"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q2RFU7 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 75F1BE5D591B9AD6

FASTA56062,432
        10         20         30         40         50         60 
MNIVQETKRR LAAALTDAAA TARAAGEISY DELPDFVIET PRDKTHGDFA ANLALLLARQ 

        70         80         90        100        110        120 
ARQSPRNVAA AIVRHLERPQ PGVARVEVAG PGFINFTLDN QWLLPVLPAV LAEDDHYGWS 

       130        140        150        160        170        180 
NIGQGAKVQV EFVSANPTGL LHMGNARGAA LGDSIANLLT AVGYDVTREF YINDAGNQIE 

       190        200        210        220        230        240 
NFGLSLEARY LQALGQEASI PEDGYHGEDL VATVGRFIAK YGDKYLDTDP ALRREMLVRF 

       250        260        270        280        290        300 
ALEEKLDAIR RALEDFGVTY DVWFSEQSLH DSGAVARAIA DLEKAGYIYE KDGALWFKAT 

       310        320        330        340        350        360 
SFGDVKDEVV VRKNGIPTYF AADIAYHRNK FERGFERVIN IWGADHHGHV ARLKGALQAL 

       370        380        390        400        410        420 
GYDPRRLEVV LMQLVRLYQG GEILRMSKRT GQYVTLEELI EEVGRDAARY FFVMLKSDSH 

       430        440        450        460        470        480 
LEFDLDLARS QSADNPVYYV QYAHARICSI LRLAKDRGLE VPPAREARLE LLQDPAELEL 

       490        500        510        520        530        540 
IKQIAAWPDT VAGAAQALEP HRLTRFAHDL ASLFHSFYTS CRVLADDPEV RKARLVLVEA 

       550        560 
TRITLRNVLH LLGVTAPERM 

« Hide

References

[1]"The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)."
Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C., Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W.
Environ. Microbiol. 10:2550-2573(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39073.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000232 Genomic DNA. Translation: ABC20692.1.
RefSeqYP_431235.1. NC_007644.1.

3D structure databases

ProteinModelPortalQ2RFU7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264732.Moth_2410.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC20692; ABC20692; Moth_2410.
GeneID3830777.
KEGGmta:Moth_2410.
PATRIC22642320. VBIMooThe6753_2624.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMAMEHMGFG.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycMTHE264732:GH0A-2495-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_MOOTA
AccessionPrimary (citable) accession number: Q2RFU7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 24, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries