Q2RFS8 (ECFA_MOOTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Energy-coupling factor transporter ATP-binding protein EcfA
Short name=ECF transporter A component EcfA
EC=3.6.3.-

Gene names

Name:	ecfA
Synonyms:	cbiO
Ordered Locus Names:	Moth_2429

Organism

Moorella thermoacetica (strain ATCC 39073) [Reference proteome] [HAMAP]

Taxonomic identifier

264732 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteraceae › Moorella group › Moorella › Moorella thermoacetica

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates By similarity.
Subunit structure	Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A components) and 2 transmembrane proteins (T component) By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Energy-coupling factor transporter ATP-binding protein EcfA		PRO_0000287965
Regions
	Domain	2 – 237	236	ABC transporter
	Nucleotide binding	36 – 43	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2RFS8 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 8B0D5EC7F65BA56D	FASTA	276	30,004
	10 20 30 40 50 60 MIAIQGATYI YPGSTVPALE KIDLAIEPGE FLAITGPNGS GKSTLARLLN GLLRPRQGRV 70 80 90 100 110 120 LVDGMDTGDD TALITIRRRV GMVFQDPDNQ LVAATVAEDV AFGLENLGLP PAEIEKRVDL 130 140 150 160 170 180 ALRSVGLEDL AARPPHLLSG GQKQRLALAG VLAMEPRYLV LDEATAMLDP VAREEILEQV 190 200 210 220 230 240 LRLRQEQGIA IILITHLMEE AVRADRMLIM KSGRIFWQGS PRELSYQERI LAAAGLRLPA 250 260 270 VIALAKSLRQ GGIKLATNPV CVEELARALW KLASRE

References

[1]

"The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)." Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C., Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W. Environ. Microbiol. 10:2550-2573(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39073.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000232 Genomic DNA. Translation: ABC20711.1.
RefSeq	YP_431254.1. NC_007644.1.
3D structure databases
ProteinModelPortal	Q2RFS8.
ModBase	Search...
Protein-protein interaction databases
STRING	264732.Moth_2429.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABC20711; ABC20711; Moth_2429.
GeneID	3831659.
KEGG	mta:Moth_2429.
PATRIC	22642366. VBIMooThe6753_2647.
Phylogenomic databases
eggNOG	COG1122.
KO	K16786.
Enzyme and pathway databases
BioCyc	MTHE264732:GH0A-2519-MONOMER.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR015856. ABC_transpr_CbiO. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51246. CBIO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ECFA_MOOTA

Accession

Primary (citable) accession number: Q2RFS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	January 24, 2006
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program